Catalog No.
YHN27801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gly607-Thr702
Predicted molecular weight
21.68 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q7Z2K8
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
GRIN1, GPRIN1, G protein-regulated inducer of neurite outgrowth 1, KIAA1893
5-HT6 receptors: Contemporary views on their neurobiological and pharmacological relevance in neuropsychiatric disorders., PMID:40347153
Targeted NMDA receptor knockdown in recall-activated neuronal ensembles impairs remote fear extinction., PMID:40188029
Bridging the gap: insights into sensorimotor deficits in NMDA receptor antibody encephalitis., PMID:40026244
Disrupted callosal connectivity underlies long-lasting sensory-motor deficits in an NMDA receptor antibody encephalitis mouse model., PMID:39739422
Combination of Haloperidol With UNC9994, β-arrestin-Biased Analog of Aripiprazole, Ameliorates Schizophrenia-Related Phenotypes Induced by NMDAR Deficit in Mice., PMID:39612588
SETD2 deficiency in peripheral sensory neurons induces allodynia by promoting NMDA receptor expression through NFAT5 in rodent models., PMID:39476923
Foxg1 regulates translation of neocortical neuronal genes, including the main NMDA receptor subunit gene, Grin1., PMID:39183266
A refined formula derived from Jiawei-Xiaoyao pill exerts rapid antidepressant-like effects in LPS-induced depression by reducing neuroinflammation and restoring neuroplasticity signaling., PMID:39094756
TFAP2A is involved in neuropathic pain by regulating Grin1 expression in glial cells of the dorsal root ganglion., PMID:39009095
Conditional deletion of the AMPA-GluA1 and NMDA-GluN1 receptor subunit genes in midbrain D1 neurons does not alter cocaine reward in mice., PMID:39002853
Loss of dysbindin-1 in excitatory neurons in mice impacts NMDAR-dependent behaviors, neuronal morphology and synaptic transmission in the ventral hippocampus., PMID:38956130
Src dependency of the regulation of LTP by alternative splicing of GRIN1 exon 5., PMID:38853562
The Expression and Functionality of CB1R-NMDAR Complexes Are Decreased in A Parkinson's Disease Model., PMID:38474266
Glutamate ionotropic receptor NMDA type subunit 1: A novel potential protein target of dapagliflozin against renal interstitial fibrosis., PMID:36736528
GluN1 antibody causes behavioral deficits in prepulse inhibition and memory through CaMKIIβ signaling., PMID:36417808
Methylated DNA markers for plasma detection of ovarian cancer: Discovery, validation, and clinical feasibility., PMID:35370009
Circular RNA circ_0002360 regulates the Taxol resistance and malignant behaviors of Taxol-resistant non-small cell lung cancer cells by microRNA-585-3p-dependent modulation of G protein regulated inducer of neurite outgrowth 1., PMID:35293280
Deletion of Grin1 in mouse megakaryocytes reveals NMDA receptor role in platelet function and proplatelet formation., PMID:35245376
Dietary Exposure to Flame Retardant Tris (2-Butoxyethyl) Phosphate Altered Neurobehavior and Neuroinflammatory Responses in a Mouse Model of Allergic Asthma., PMID:35054842
14-3-3 proteins promote synaptic localization of N-methyl d-aspartate receptors (NMDARs) in mouse hippocampal and cortical neurons., PMID:34962957
Potential Immune Biomarker Candidates and Immune Subtypes of Lung Adenocarcinoma for Developing mRNA Vaccines., PMID:34917077
miR-654-5p promotes gastric cancer progression via the GPRIN1/NF-κB pathway., PMID:34805531
Alternative Splicing Mechanisms Underlying Opioid-Induced Hyperalgesia., PMID:34680965
Intrathecal interleukin-1β decreases sigma-1 receptor expression in spinal astrocytes in a murine model of neuropathic pain., PMID:34607109
Sex-specific effect of prenatal alcohol exposure on N-methyl-D-aspartate receptor function in orbitofrontal cortex pyramidal neurons of mice., PMID:34523139
Chronic presence of blood circulating anti-NMDAR1 autoantibodies impairs cognitive function in mice., PMID:34473764
A novel lncRNA-miRNA-mRNA competing endogenous RNA regulatory network in lung adenocarcinoma and kidney renal papillary cell carcinoma., PMID:34453499
Structural basis of ketamine action on human NMDA receptors., PMID:34321660
Novel and atypical pathways for serotonin signaling., PMID:34195691
Alternative splicing of GluN1 gates glycine site-dependent nonionotropic signaling by NMDAR receptors., PMID:34187890
Specific activation of GluN1-N2B NMDA receptors underlies facilitation of cortical spreading depression in a genetic mouse model of migraine with reduced astrocytic glutamate clearance., PMID:34111520
Presynaptic NMDA receptors facilitate short-term plasticity and BDNF release at hippocampal mossy fiber synapses., PMID:34061025
The α2δ-1/NMDA receptor complex is involved in brain injury after intracerebral hemorrhage in mice., PMID:34032393
Aconiti lateralis Radix Praeparata inhibits Alzheimer's disease by regulating the complex regulation network with the core of GRIN1 and MAPK1., PMID:33784489
D-Aspartate consumption selectively promotes intermediate-term spatial memory and the expression of hippocampal NMDA receptor subunits., PMID:33731750
Anti-NMDAR encephalitis induced in mice by active immunization with a peptide from the amino-terminal domain of the GluN1 subunit., PMID:33612107
Acute D-Serine Co-Agonism of β-Cell NMDA Receptors Potentiates Glucose-Stimulated Insulin Secretion and Excitatory β-Cell Membrane Activity., PMID:33430405
Cornel Iridoid Glycoside Suppresses Hyperactivity Phenotype in rTg4510 Mice through Reducing Tau Pathology and Improving Synaptic Dysfunction., PMID:33428130
NMDA Receptor Enhances Correlation of Spontaneous Activity in Neonatal Barrel Cortex., PMID:33372060
The NMDAR GluN1-1a C-terminus binds to CaM and regulates synaptic function., PMID:33248694
Neuronal surface P antigen (NSPA) modulates postsynaptic NMDAR stability through ubiquitination of tyrosine phosphatase PTPMEG., PMID:33158444
The escalation in ethanol consumption following chronic intermittent ethanol exposure is blunted in mice expressing ethanol-resistant GluN1 or GluN2A NMDA receptor subunits., PMID:33052417
Deletion of the Gene Encoding the NMDA Receptor GluN1 Subunit in Schwann Cells Causes Ultrastructural Changes in Remak Bundles and Hypersensitivity in Pain Processing., PMID:33051351
Autoimmune encephalitis mediated by B-cell response against N-methyl-d-aspartate receptor., PMID:32893288
Consequences of NMDA receptor deficiency can be rescued in the adult brain., PMID:32807843
G protein regulated inducer of neurite outgrowth 1 is a potential marker for lung cancer prognosis., PMID:32755106
SIRT1 accelerates the progression of activity-based anorexia., PMID:32499508
Early correction of synaptic long-term depression improves abnormal anxiety-like behavior in adult GluN2B-C456Y-mutant mice., PMID:32353004
MK-801 impairs working memory on the Trial-Unique Nonmatch-to-Location test in mice, but this is not exclusively mediated by NMDA receptors on PV+ interneurons or forebrain pyramidal cells., PMID:32330470
Modulation of NR1 receptor by CaMKIIα plays an important role in chronic itch development in mice., PMID:32112850
For research use only. Not for human or drug use.
