Catalog No.
YHG76301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gly22-Ile407
Predicted molecular weight
46.54 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q14240
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
EIF4F, EIF4A2, DDX2B, eIF4A-II, Eukaryotic initiation factor 4A-II, ATP-dependent RNA helicase eIF4A-2, eIF-4A-II
BLF1 Affects ATP Hydrolysis Catalyzed by Native and Mutated eIF4A1 and eIF4A2 Proteins., PMID:40423315
Novel loci for triglyceride/HDL-C ratio longitudinal change among subjects without T2D., PMID:39557295
Comparative investigation among fluorescence in situ hybridization, DNA- and RNA-sequencing on detecting MYC, BCL2, and BCL6 rearrangements in high-grade B-cell lymphomas., PMID:39556426
Critical and differential roles of eIF4A1 and eIF4A2 in B-cell development and function., PMID:39516355
Artificial neural network inference analysis identified novel genes and gene interactions associated with skeletal muscle aging., PMID:39210538
RBM12 drives PD-L1-mediated immune evasion in hepatocellular carcinoma by increasing JAK1 mRNA translation., PMID:39187545
Anti-tumor Effects of the eIF4A Inhibitor Didesmethylrocaglamide and Its Derivatives in Human and Canine Osteosarcomas., PMID:38947012
Functional transcriptome analysis revealed major changes in pathways affecting systems biology of Tharparkar cattle under seasonal heat stress., PMID:38855148
Mutant U2AF1-Induced Mis-Splicing of mRNA Translation Genes Confers Resistance to Chemotherapy in Acute Myeloid Leukemia., PMID:38417135
RNA helicase EIF4A1-mediated translation is essential for the GC response., PMID:38011999
Dystonia Linked to EIF4A2 Haploinsufficiency: A Disorder of Protein Translation Dysfunction., PMID:37485550
Astrocytes express aberrant immunoglobulins as putative gatekeeper of astrocytes to neuronal progenitor conversion., PMID:37015912
Exploring the targeting spectrum of rocaglates among eIF4A homologs., PMID:36882295
Identification of tumor antigens and immune landscapes for bladder urothelial carcinoma mRNA vaccine., PMID:36761744
Shear Stress Markedly Alters the Proteomic Response to Hypoxia in Human Pulmonary Endothelial Cells., PMID:36730645
Rare EIF4A2 variants are associated with a neurodevelopmental disorder characterized by intellectual disability, hypotonia, and epilepsy., PMID:36528028
Copy number variation of EIF4A2 loci related to phenotypic traits in Chinese cattle., PMID:36052549
The splicing factor RBM17 drives leukemic stem cell maintenance by evading nonsense-mediated decay of pro-leukemic factors., PMID:35781533
Identification of lysine acetylome of oral squamous cell carcinoma by label-free quantitative proteomics., PMID:35489685
eIF4A2 targets developmental potency and histone H3.3 transcripts for translational control of stem cell pluripotency., PMID:35353581
NMD is required for timely cell fate transitions by fine-tuning gene expression and regulating translation., PMID:35241478
Deregulation of microtubule organization and RNA metabolism in Arx models for lissencephaly and developmental epileptic encephalopathy., PMID:35094084
Translational and post-translational control of human naïve versus primed pluripotency., PMID:35005567
Transcriptome analysis reveals the involvement of ubiquitin-proteasome pathway in the regulation of muscle growth of rice flower carp., PMID:34942523
Expression and Functional Roles of Eukaryotic Initiation Factor 4A Family Proteins in Human Cancers., PMID:34869305
Assessing eukaryotic initiation factor 4F subunit essentiality by CRISPR-induced gene ablation in the mouse., PMID:34559254
The effects of NCBP3 on METTL3-mediated m6A RNA methylation to enhance translation process in hypoxic cardiomyocytes., PMID:34382339
LncRNA H19 governs mitophagy and restores mitochondrial respiration in the heart through Pink1/Parkin signaling during obesity., PMID:34050133
Identification of the transgene insertion site for an adipocyte-specific adiponectin-cre model and characterization of the functional consequences., PMID:33565916
KAT6A amplifications are associated with shorter progression-free survival and overall survival in patients with endometrial serous carcinoma., PMID:32877461
RNA-tethering assay and eIF4G:eIF4A obligate dimer design uncovers multiple eIF4F functional complexes., PMID:32749456
Obesity significantly alters the human sperm proteome, with potential implications for fertility., PMID:32026202
Selecting Appropriate Reference Genes for Quantitative Real-Time Polymerase Chain Reaction Studies in Isolated and Cultured Ocular Surface Epithelia., PMID:31873107
eIF4A2 drives repression of translation at initiation by Ccr4-Not through purine-rich motifs in the 5'UTR., PMID:31791371
The DEAD-box RNA helicase eIF4A regulates plant development and interacts with the hnRNP LIF2L1 in Physcomitrella patens., PMID:31781862
Amidino-Rocaglates: A Potent Class of eIF4A Inhibitors., PMID:31519508
Reconstruction of the lncRNA-miRNA-mRNA network based on competitive endogenous RNA reveal functional lncRNAs in Cerebral Infarction., PMID:31434962
MicroRNA-5195-3p enhances the chemosensitivity of triple-negative breast cancer to paclitaxel by downregulating EIF4A2., PMID:31308851
DEAD-box helicase eIF4A2 inhibits CNOT7 deadenylation activity., PMID:31180491
Eukaryotic initiation factor 4A2 promotes experimental metastasis and oxaliplatin resistance in colorectal cancer., PMID:31088567
EIF4A2 interacts with the membrane protein of transmissible gastroenteritis coronavirus and plays a role in virus replication., PMID:30583231
PRMT1 Deficiency in Mouse Juvenile Heart Induces Dilated Cardiomyopathy and Reveals Cryptic Alternative Splicing Products., PMID:30321814
eIF4A2 is a host factor required for efficient HIV-1 replication., PMID:29842983
Identification of novel MECOM gene fusion and personalized therapeutic targets through integrative clinical sequencing in secondary acute myeloid leukemia in a patient with severe congenital neutropenia: a case report and literature review., PMID:29572239
β-glucuronidase use as a single internal control gene may confound analysis in FMR1 mRNA toxicity studies., PMID:29474364
Host-Virus Protein Interaction Network Reveals the Involvement of Multiple Host Processes in the Life Cycle of Hepatitis E Virus., PMID:29404423
Discovery and Characterization of a Eukaryotic Initiation Factor 4A-3-Selective Inhibitor That Suppresses Nonsense-Mediated mRNA Decay., PMID:28440616
Structural modelling and phylogenetic analyses of PgeIF4A2 (Eukaryotic translation initiation factor) from Pennisetum glaucum reveal signature motifs with a role in stress tolerance and development., PMID:28358146
Identification of potential molecular associations between chikungunya virus non-structural protein 2 and human host proteins., PMID:28105853
NanoLC-MS coupling of liquid microjunction microextraction for on-tissue proteomic analysis., PMID:27836619
For research use only. Not for human or drug use.
