Catalog No.
YHG40501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Glu331-Lys451
Predicted molecular weight
17.55 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q13111
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Chromatin assembly factor 1 subunit A, CAF-I p150, CHAF1A, CAF, CAF1P150, Chromatin assembly factor I p150 subunit, hp150, CAF-1 subunit A, CAF-I 150 kDa subunit
Chromatin assembly factor 1 subunit A promotes TLS pathway by recruiting E3 ubiquitin ligase RAD18 in cancer cells., PMID:40025006
Chromatin assembly factor subunit CHAF1A as a monogenic cause for oculo-auriculo-vertebral spectrum., PMID:39333427
Synthesis and biological evaluation of vioprolide B and its dehydrobutyrine-glycine analogue., PMID:39015034
An oncogene regulating chromatin favors response to immunotherapy: Oncogene CHAF1A and immunotherapy outcomes., PMID:38235318
Inhibition of CAF-1 histone chaperone complex triggers cytosolic DNA and dsRNA sensing pathways and induces intrinsic immunity of hepatocellular carcinoma., PMID:38051950
Co-Expression of Chromatin Assembly Factor 1 Subunit A and Proliferating Cell Nuclear Antigen Is a Prognostic Biomarker of Esophageal Cancer., PMID:37189802
The histone H3/H4 chaperone CHAF1B prevents the mislocalization of CENP-A for chromosomal stability., PMID:37129573
RNA methylation-related genes of m6A, m5C, and m1A predict prognosis and immunotherapy response in cervical cancer., PMID:37042849
Impact of Asp/Glu-ADP-ribosylation on protein-protein interaction and protein function., PMID:36453556
Unorthodox PCNA Binding by Chromatin Assembly Factor 1., PMID:36232396
Effects of lncRNA MTC on protein expression in skin fibroblasts of Liaoning Cashmere goat based on iTRAQ technique., PMID:36093624
Aberrant SPOP-CHAF1A ubiquitination axis triggers tumor autophagy that endows a therapeutical vulnerability in diffuse large B cell lymphoma., PMID:35773729
Multi-staged gene expression profiling reveals potential genes and the critical pathways in kidney cancer., PMID:35508649
Biochemical and Structural Insights into the Winged Helix Domain of P150, the Largest Subunit of the Chromatin Assembly Factor 1., PMID:35216276
CHAF1A/B mediate silencing of unintegrated HIV-1 DNAs early in infection., PMID:35074917
Identifying the hub genes in non-small cell lung cancer by integrated bioinformatics methods and analyzing the prognostic values., PMID:34749208
DNA methylation mediated downregulation of histone H3 variant H3.3 affects cell proliferation contributing to the development of HCC., PMID:34626773
CHAF1A Blocks Neuronal Differentiation and Promotes Neuroblastoma Oncogenesis via Metabolic Reprogramming., PMID:34365742
Detection of CAF-1/p60 in peripheral blood as a potential biomarker of HNSCC tumors., PMID:34237585
FMR1/circCHAF1A/miR-211-5p/HOXC8 feedback loop regulates proliferation and tumorigenesis via MDM2-dependent p53 signaling in GSCs., PMID:34017077
Identification and external validation of a prognostic signature associated with DNA repair genes in gastric cancer., PMID:33785812
MiR-1179 is downregulated in cervical cancer and its overexpression suppresses cancer cells invasion by targeting CHAF1A/ZEB1., PMID:33740340
Histone chaperone CAF-1 promotes HIV-1 latency by leading the formation of phase-separated suppressive nuclear bodies., PMID:33739466
Genetic variation and urine cadmium levels: ABCC1 effects in the Strong Heart Family Study., PMID:33640655
Five candidate biomarkers associated with the diagnosis and prognosis of cervical cancer., PMID:33616161
CHAF1A overexpression in human retinoblastoma promotes cell proliferation and suppresses apoptosis., PMID:33277876
Role of chromatin assembly factor-1/p60 and poly [ADP-ribose] polymerase 1 in mycosis fungoides., PMID:33098490
Dynamic Incorporation of Histone H3 Variants into Chromatin Is Essential for Acquisition of Aggressive Traits and Metastatic Colonization., PMID:31564638
Histone chaperone CHAF1A impacts the outcome of fluoropyrimidines-based adjuvant therapy in gastric cancer by regulating the expression of thymidylate synthetase., PMID:31377317
The histone chaperone CAF-1 cooperates with the DNA methyltransferases to maintain Cd4 silencing in cytotoxic T cells., PMID:30975723
Functional high-throughput screening reveals miR-323a-5p and miR-342-5p as new tumor-suppressive microRNA for neuroblastoma., PMID:30770954
MiR-520b inhibited metastasis and proliferation of non-small cell lung cancer by targeting CHAF1A., PMID:30536318
Oncogenic potential of CHAF1A in gastric cancer: A novel link with Helicobacter pylori-driven carcinogenesis?, PMID:30487061
Butyrate-Induced In Vitro Colonocyte Differentiation Network Model Identifies ITGB1, SYK, CDKN2A, CHAF1A, and LRP1 as the Prognostic Markers for Colorectal Cancer Recurrence., PMID:30475060
CHAF1A interacts with TCF4 to promote gastric carcinogenesis via upregulation of c-MYC and CCND1 expression., PMID:30449701
Reprogramming of H3K9me3-dependent heterochromatin during mammalian embryo development., PMID:29686265
NuRD and CAF-1-mediated silencing of the D4Z4 array is modulated by DUX4-induced MBD3L proteins., PMID:29533181
The Histone Chaperones ASF1 and CAF-1 Promote MMS22L-TONSL-Mediated Rad51 Loading onto ssDNA during Homologous Recombination in Human Cells., PMID:29478807
[Highly expressed CHAF1A and PCNA are positively associated with malignancy of cervical squamous cell carcinoma]., PMID:29382432
CHAF1A, the largest subunit of the chromatin assembly factor 1 complex, regulates the growth of H1299 human non-small cell lung cancer cells by inducing G0/G1 cell cycle arrest., PMID:29201167
Over-expression of CHAF1A in Epithelial Ovarian Cancer can promote cell proliferation and inhibit cell apoptosis., PMID:28286267
The Chromatin Assembly Factor Complex 1 (CAF1) and 5-Azacytidine (5-AzaC) Affect Cell Motility in Src-transformed Human Epithelial Cells., PMID:27872192
Regulation of oxidized base damage repair by chromatin assembly factor 1 subunit A., PMID:27794043
Common genetic variations in cell cycle and DNA repair pathways associated with pediatric brain tumor susceptibility., PMID:27613841
Over-expression of CHAF1A promotes cell proliferation and apoptosis resistance in glioblastoma cells via AKT/FOXO3a/Bim pathway., PMID:26740175
The histone chaperone CAF-1 safeguards somatic cell identity., PMID:26659182
Systematic identification of factors for provirus silencing in embryonic stem cells., PMID:26365490
The role of the chromatin assembly complex (CAF-1) and its p60 subunit (CHAF1b) in homeostasis and disease., PMID:26066981
Cell cycle regulation of human DNA repair and chromatin remodeling genes., PMID:25881042
System-wide Analysis of SUMOylation Dynamics in Response to Replication Stress Reveals Novel Small Ubiquitin-like Modified Target Proteins and Acceptor Lysines Relevant for Genome Stability., PMID:25755297
For research use only. Not for human or drug use.
