Catalog No.
YHG04201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Ser145
Predicted molecular weight
19.23 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q05195
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Protein MAD, MXD1, MAD, Max dimerizer 1, Max dimerization protein 1
BARD1-mediated stabilization of METTL14 promotes retinal neovascularization by m6A-modifying MXD1 mRNA on a YTHDF2-dependent manner., PMID:40303324
TRMT10A regulates tRNA-ArgCCT m1G9 modification to generate tRNA-derived fragments influencing vasculogenic mimicry formation in glioblastoma., PMID:40140670
Advancing Understanding and Therapeutic Strategies for NUT Sarcomas: Comprehensive Review of the Literature and Two Cases., PMID:40070529
Targeting MXD1 sensitises pancreatic cancer to trametinib., PMID:39819860
The critical involvement of monocytes/macrophages in the pathogenesis of primary Sjögren's syndrome: New evidence from Mendelian randomization and single-cell sequencing., PMID:39497977
Identification of a Diagnosis and Therapeutic Inflammatory Response-Related Gene Signature Associated with Esophageal Adenocarcinoma., PMID:37602454
Sarcoma with MGA::NUTM1 fusion: a report of three cases and literature review., PMID:37442637
Bayesian Machine Learning Enables Identification of Transcriptional Network Disruptions Associated with Drug-Resistant Prostate Cancer., PMID:36779846
Polyphenon E Effects on Gene Expression in PC-3 Prostate Cancer Cells., PMID:36430806
HOXA5 inhibits the proliferation of extrahepatic cholangiocarcinoma cells by enhancing MXD1 expression and activating the p53 pathway., PMID:36167790
Identification and validation of aging-related genes in COPD based on bioinformatics analysis., PMID:35609226
NUTM1-fusion positive malignant neoplasms of the genitourinary tract: A report of six cases highlighting involvement of unusual anatomic locations and histologic heterogeneity., PMID:35430756
Polycomb group ring finger protein 6 suppresses Myc-induced lymphomagenesis., PMID:35422437
Primary Spindle Cell Sarcoma of the Lung with MGA::NUTM1 Fusion: An Extremely Rare Case of a Potentially Emerging Entity and Review of the Literature., PMID:35388715
Normal and Neoplastic Growth Suppression by the Extended Myc Network., PMID:35203395
The Cardiac Glycoside Deslanoside Exerts Anticancer Activity in Prostate Cancer Cells by Modulating Multiple Signaling Pathways., PMID:34830961
MXD1 is a Potential Prognostic Biomarker and Correlated With Specific Molecular Change and Tumor Microenvironment Feature in Esophageal Squamous Cell Carcinoma., PMID:34761715
Misleading Germ Cell Phenotype in Pulmonary NUT Carcinoma Harboring the ZNF532-NUTM1 Fusion., PMID:34232599
Lnc-HZ01 with m6A RNA methylation inhibits human trophoblast cell proliferation and induces miscarriage by up-regulating BPDE-activated lnc-HZ01/MXD1 positive feedback loop., PMID:33647641
Targeting miR-21 with NL101 blocks c-Myc/Mxd1 loop and inhibits the growth of B cell lymphoma., PMID:33537096
Vitamin D Represses the Aggressive Potential of Osteosarcoma., PMID:32955002
MXD1 regulates the H9N2 and H1N1 influenza A virus-induced chemokine expression and their replications in human macrophage., PMID:32794336
MAGI2-AS3 suppresses MYC signaling to inhibit cell proliferation and migration in ovarian cancer through targeting miR-525-5p/MXD1 axis., PMID:32681706
Role for carbohydrate response element-binding protein (ChREBP) in high glucose-mediated repression of long noncoding RNA Tug1., PMID:32467232
An MXD1-derived repressor peptide identifies noncoding mediators of MYC-driven cell proliferation., PMID:32156728
The MYCL and MXD1 transcription factors regulate the fitness of murine dendritic cells., PMID:32071205
Inhibition of Myc transcriptional activity by a mini-protein based upon Mxd1., PMID:32053209
The MicroRNA-382-5p/MXD1 Axis Relates to Breast Cancer Progression and Promotes Cell Malignant Phenotypes., PMID:31635836
Inflammatory, regulatory, and autophagy co-expression modules and hub genes underlie the peripheral immune response to human intracerebral hemorrhage., PMID:30836997
The Tumor Suppressor FBW7 and the Vitamin D Receptor Are Mutual Cofactors in Protein Turnover and Transcriptional Regulation., PMID:30606768
MXD1 regulates the imatinib resistance of chronic myeloid leukemia cells by repressing BCR-ABL1 expression., PMID:30419548
RXR Ligands Modulate Thyroid Hormone Signaling Competence in Young Xenopus laevis Tadpoles., PMID:29762675
SIRT1 regulates Mxd1 during malignant melanoma progression., PMID:29383100
NUTM1 Gene Fusions Characterize a Subset of Undifferentiated Soft Tissue and Visceral Tumors., PMID:29356724
Beta-catenin represses protein kinase D1 gene expression by non-canonical pathway through MYC/MAX transcription complex in prostate cancer., PMID:29108267
Mxd1 mediates hypoxia-induced cisplatin resistance in osteosarcoma cells by repression of the PTEN tumor suppressor gene., PMID:28543796
Biophysical characterization of the b-HLH-LZ of ΔMax, an alternatively spliced isoform of Max found in tumor cells: Towards the validation of a tumor suppressor role for the Max homodimers., PMID:28350847
MXD1 localizes in the nucleolus, binds UBF and impairs rRNA synthesis., PMID:27588501
miR-382-5p Controls Hematopoietic Stem Cell Differentiation Through the Downregulation of MXD1., PMID:27520398
A Blockade of IGF Signaling Sensitizes Human Ovarian Cancer Cells to the Anthelmintic Niclosamide-Induced Anti-Proliferative and Anticancer Activities., PMID:27497986
TCP10L synergizes with MAD1 in transcriptional suppression and cell cycle arrest through mutual interaction., PMID:26698869
The MYC-WDR5 Nexus and Cancer., PMID:26383167
Id2 deletion attenuates Apc-deficient ileal tumor formation., PMID:26163528
Models of parent-of-origin tumorigenesis in hereditary paraganglioma., PMID:26067997
Down regulation of miR-202 modulates Mxd1 and Sin3A repressor complexes to induce apoptosis of pancreatic cancer cells., PMID:25611699
In vivo quantification and perturbation of Myc-Max interactions and the impact on oncogenic potential., PMID:25326649
Drosophila Myc: A master regulator of cellular performance., PMID:25010747
Novel genetic variants modify the effect of smoking on carotid plaque burden in Hispanics., PMID:24954085
Vitamin D and its receptor during late development., PMID:24939836
Functional interactions among members of the MAX and MLX transcriptional network during oncogenesis., PMID:24857747
For research use only. Not for human or drug use.
