Catalog No.
YHF81401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gly16-Phe395
Predicted molecular weight
44.39 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q00266
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
MAT 1, Methionine adenosyltransferase 1, AdoMet synthase 1, Methionine adenosyltransferase I/III, MATA1, AMS1, S-adenosylmethionine synthase isoform type-1, MAT1A, MAT-I/III
Integrating network pharmacology, quantitative transcriptomic analysis, and experimental validation revealed the mechanism of cordycepin in the treatment of obesity., PMID:40438591
The complex post-transcriptional regulation of genes coding for methionine adenosyl transferase: New insights for liver cancer., PMID:40348354
S-adenosylmethionine deficit disrupts very low-density lipoprotein metabolism promoting liver lipid accumulation in mice., PMID:40180215
Exploration of RNA-binding proteins identified RPS27 as a potential regulator associated with Kaposi's sarcoma development., PMID:40016701
Fructose-induced progression of steatohepatitis involves disrupting aldolase B-AMPK signaling in methionine adenosyltransferase 1A deficient mice., PMID:39922455
Genetic variation and clinical phenotype analysis of hypermethioninemia caused by MAT1A gene mutation: Case report., PMID:39705457
Hypermethioninemia due to methionine adenosyltransferase I/III deficiency and brain damage., PMID:39511588
MAT1A activation of glycolysis to promote NSCLC progression depends on stabilizing CCND1., PMID:39438468
Alterations in one‑carbon metabolism and protein synthesis signals due to methionine supplementation and lipopolysaccharide challenge in Holstein fetal liver explants., PMID:39191197
A hot and cold tumor‑related prognostic signature for stage II colorectal cancer., PMID:39006949
Mechanistic safety assessment via multi-omic characterisation of systemic pathway perturbations following in vivo MAT2A inhibition., PMID:38755480
Simultaneous quantification of six proteins related to liver injury using nano liquid chromatography-tandem mass spectrometry., PMID:38605420
S-Adenosylmethionine Negatively Regulates the Mitochondrial Respiratory Chain Repressor MCJ in the Liver., PMID:38385082
A pathogenic variant in the FLCN gene presenting with pure dementia: is autophagy at the intersection between neurodegeneration and cancer?, PMID:38249578
Genetic variants identified in novel candidate genes for anorexia nervosa and analysis of molecular pathways for diagnostic applications., PMID:38112957
Sumoylation of methionine adenosyltransferase alpha 1 promotes mitochondrial dysfunction in alcohol-associated liver disease., PMID:38100286
Hepatic prohibitin 1 and methionine adenosyltransferase α1 defend against primary and secondary liver cancer metastasis., PMID:38086446
Screening of 1.17 million newborns for inborn errors of metabolism using tandem mass spectrometry in Shanghai, China: A 19-year report., PMID:38061323
Formaldehyde regulates S-adenosylmethionine biosynthesis and one-carbon metabolism., PMID:37917677
Intermediate metabolites and molecular correlates of one‑carbon and nutrient metabolism differ in tissues from Holstein fetuses., PMID:37678126
Construction and validation of a prognostic model for colon adenocarcinoma based on bile acid metabolism-related genes., PMID:37543674
Hepatic levels of S-adenosylmethionine regulate the adaptive response to fasting., PMID:37527658
Translocation of Methionine Adenosyl Transferase MAT2A and Its Prognostic Relevance for Liver Hepatocellular Carcinoma., PMID:37240447
MAT1A Suppression by the CTBP1/HDAC1/HDAC2 Transcriptional Complex Induces Immune Escape and Reduces Ferroptosis in Hepatocellular Carcinoma., PMID:37230466
Hyperphosphorylation of hepatic proteome characterizes nonalcoholic fatty liver disease in S-adenosylmethionine deficiency., PMID:36756374
A liver secretome gene signature-based approach for determining circulating biomarkers of NAFLD severity., PMID:36260611
Methionine Adenosyltransferase I/III Deficiency Detected by Newborn Screening., PMID:35885946
Small-Molecule-Mediated Split-Aptamer Assembly for Inducible CRISPR-dCas9 Transcription Activation., PMID:35700146
ADH1C Facilitates Cisplatin Resistance of Lung Adenocarcinoma Cells., PMID:35612423
Single nucleotide polymorphisms to predict acute radiation dermatitis in breast cancer patients: A systematic review and meta-analysis., PMID:35301098
Methionine adenosyltransferase 1a antisense oligonucleotides activate the liver-brown adipose tissue axis preventing obesity and associated hepatosteatosis., PMID:35232994
S-Adenosylmethionine: From the Discovery of Its Inhibition of Tumorigenesis to Its Use as a Therapeutic Agent., PMID:35159219
Downregulation of Methionine Cycle Genes MAT1A and GNMT Enriches Protein-Associated Translation Process and Worsens Hepatocellular Carcinoma Prognosis., PMID:35008908
Polar Interactions at the Dimer-Dimer Interface of Methionine Adenosyltransferase MAT I Control Tetramerization., PMID:34948004
Hyperlipidemia May Synergize with Hypomethylation in Establishing Trained Immunity and Promoting Inflammation in NASH and NAFLD., PMID:34859106
[Identification of LAMTOR1-regulated metabolites using ultra-performance liquid chromatography coupled with time-of-flight mass spectrometry in malignant transformation of liver inflammation]., PMID:34505434
S-adenosylmethionine inhibits la ribonucleoprotein domain family member 1 in murine liver and human liver cancer cells., PMID:34449924
Methionine supply during the peripartum period and early lactation alter immunometabolic gene expression in cytological smear and endometrial tissue of holstein cows., PMID:34365138
Deregulated 14-3-3ζ and methionine adenosyltransferase α1 interplay promotes liver cancer tumorigenesis in mice and humans., PMID:34349244
A conditional multi-trait sequence GWAS discovers pleiotropic candidate genes and variants for sheep wool, skin wrinkle and breech cover traits., PMID:34238208
MAT2A Localization and Its Independently Prognostic Relevance in Breast Cancer Patients., PMID:34065390
Effects of Three-Month Administration of High-Saturated Fat Diet and High-Polyunsaturated Fat Diets with Different Linoleic Acid (LA, C18:2n-6) to α-Linolenic Acid (ALA, C18:3n-3) Ratio on the Mouse Liver Proteome., PMID:34063343
Mining of RNA Methylation-Related Genes and Elucidation of Their Molecular Biology in Gallbladder Carcinoma., PMID:33718182
Interspecific Variation in One-Carbon Metabolism within the Ovarian Follicle, Oocyte, and Preimplantation Embryo: Consequences for Epigenetic Programming of DNA Methylation., PMID:33673278
One-carbon, carnitine, and glutathione metabolism-related biomarkers in peripartal Holstein cows are altered by prepartal body condition., PMID:33455750
Quantitative determination of histone methylation via fluorescence resonance energy transfer (FRET) technology in immortalized bovine mammary alveolar epithelial cells supplemented with methionine., PMID:33347518
Methionine metabolism in chronic liver diseases: an update on molecular mechanism and therapeutic implication., PMID:33273451
Methionine adenosyltransferase I/III deficiency: Long-term follow-up and treatment of 3 adult siblings., PMID:32980525
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) dysregulates hepatic one carbon metabolism during the progression of steatosis to steatohepatitis with fibrosis in mice., PMID:32908189
S-Adenosylmethionine Deficiency and Brain Accumulation of S-Adenosylhomocysteine in Thioacetamide-Induced Acute Liver Failure., PMID:32709137
For research use only. Not for human or drug use.
