Catalog No.
YHD99601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Lys313-Lys361
Predicted molecular weight
17.91 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P32249
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
GPR183, G-protein coupled receptor 183, hEBI2, Epstein-Barr virus-induced G-protein coupled receptor 2, EBI2, EBV-induced G-protein coupled receptor 2
The regulatory functions of G protein-coupled receptors signaling pathways in B cell differentiation and development contributing to autoimmune diseases., PMID:40307944
Redirecting cytotoxic lymphocytes to breast cancer tumors via metabolite-sensing receptors., PMID:40196673
Beyond CCR7: dendritic cell migration in type 2 inflammation., PMID:40093008
Mitochondria-enriched hematopoietic stem cells exhibit elevated self-renewal capabilities, thriving within the context of aged bone marrow., PMID:40050412
Differential expression and modulation of EBI2 and 7α,25-OHC synthesizing (CH25H, CYP7B1) and degrading (HSD3B7) enzymes in mouse and human brain vascular cells., PMID:39999050
Inflammation switches the chemoattractant requirements for naive lymphocyte entry into lymph nodes., PMID:39708807
Exploring G Protein-Coupled Receptors in Hematological Cancers., PMID:39698279
Sexual Dimorphism in the Immunometabolic Role of Gpr183 in Mice., PMID:39545055
Accelerated remyelination and immune modulation by the EBI2 agonist 7α,25-dihydroxycholesterol analogue in the cuprizone model., PMID:39489122
Oxysterols contribute to immune cell recruitment in SLE skin lesions., PMID:39438997
Oxysterol Sensing Through GPR183 Triggers Endothelial Senescence in Hypertension., PMID:39176657
Potent, Selective Agonists for the Cannabinoid-like Orphan G Protein-Coupled Receptor GPR18: A Promising Drug Target for Cancer and Immunity., PMID:38885438
Exploring the Activation Mechanism of the GPR183 Receptor., PMID:38877985
RNA sequencing screening and gene function analysis uncover G protein-coupled receptor 183 as a key mediator for methionine to stimulate milk synthesis in mouse mammary epithelial cells., PMID:38831511
The EBI2 receptor is coexpressed with CCR5 in CD4 + T cells and boosts HIV-1 R5 replication., PMID:38770825
The role of orphan G protein-coupled receptors in pain., PMID:38590871
First report on chemometrics-driven multilayered lead prioritization in addressing oxysterol-mediated overexpression of G protein-coupled receptor 183., PMID:38460065
Discovery of a Highly Potent Oxysterol Receptor GPR183 Antagonist Bearing the Benzo[d]thiazole Structural Motif for the Treatment of Inflammatory Bowel Disease (IBD)., PMID:38417036
Discovery of a First-in-Class GPR183 Antagonist for the Potential Treatment of Rheumatoid Arthritis., PMID:38047891
Single-cell transcriptomics reveals tumor-infiltrating B cell function after neoadjuvant pembrolizumab and chemotherapy in non-small cell lung cancer., PMID:37931147
Ligand entry pathways control the chemical space recognized by GPR183., PMID:37829039
Endogenous and Therapeutic 25-Hydroxycholesterols May Worsen Early SARS-CoV-2 Pathogenesis in Mice., PMID:37578898
The Oxysterol Receptor EBI2 Links Innate and Adaptive Immunity to Limit IFN Response and Systemic Lupus Erythematosus., PMID:37469011
Smoking during pregnancy is associated with the placental proteome., PMID:37209868
G protein-coupled receptor 183 mediates the sensitization of Burkitt lymphoma tumors to CD47 immune checkpoint blockade by anti-CD20/PI3Kδi dual therapy., PMID:37153563
Migration mediated by the oxysterol receptor GPR183 depends on arrestin coupling but not receptor internalization., PMID:37014928
Embryonic type 3 innate lymphoid cells sense maternal dietary cholesterol to control local Peyer's patch development., PMID:36993524
Oxysterol metabolism dictates macrophage influx during SARS-CoV-2 infection., PMID:36858446
Skin γδ T cell inflammatory responses are hardwired in the thymus by oxysterol sensing via GPR183 and calibrated by dietary cholesterol., PMID:36842431
A dietary cholesterol by-product regulates intestinal IgA secretion via GPR183., PMID:36807643
Distinct transcriptional signatures in purified circulating immune cells drive heterogeneity in disease location in IBD., PMID:36746519
An epithelial cell-derived metabolite tunes immunoglobulin A secretion by gut-resident plasma cells., PMID:36658240
Identification of a potential structure-based GPCR drug for interstitial cystitis/bladder pain syndrome: in silico protein structure analysis and molecular docking., PMID:36576541
GPR183 antagonism reduces macrophage infiltration in influenza and SARS-CoV-2 infection., PMID:36396144
CD4+-mediated colitis in mice is independent of the GPR183 and GPR18 pathways., PMID:36389671
Evaluation of endogenous and therapeutic 25-hydroxycholesterols in murine models of pulmonary SARS-CoV-2 infection., PMID:36263064
CD56bright CD16- natural killer cells as an important regulatory mechanism in chronic graft-versus-host disease., PMID:36200416
Activation of GPR183 by 7α,25-Dihydroxycholesterol Induces Behavioral Hypersensitivity through Mitogen-Activated Protein Kinase and Nuclear Factor-κB., PMID:36116795
GPR183 Regulates 7α,25-Dihydroxycholesterol-Induced Oxiapoptophagy in L929 Mouse Fibroblast Cell., PMID:35956750
Rapid GPR183-mediated recruitment of eosinophils to the lung after Mycobacterium tuberculosis infection., PMID:35905725
Abnormal lower expression of GPR183 in peripheral blood T and B cell subsets of systemic lupus erythematosus patients., PMID:35875859
Structures of EBI2 shed light on the treatment of autoimmune diseases., PMID:35803240
25-Hydroxycholesterol as a Signaling Molecule of the Nervous System., PMID:35790411
Characterization of lncRNA-Based ceRNA Network and Potential Prognostic Hub Genes for Sepsis., PMID:35774747
Germinal Center-Related G Protein-Coupled Receptors in Antibody-Mediated Autoimmune Skin Diseases: from Basic Research to Clinical Trials., PMID:35674978
Structures of oxysterol sensor EBI2/GPR183, a key regulator of the immune response., PMID:35537452
Germline and somatic genetic variability of oxysterol-related genes in breast cancer patients with early disease of the luminal subtype., PMID:35525372
EBI2 is a negative modulator of brown adipose tissue energy expenditure in mice and human brown adipocytes., PMID:35351968
A Blunted GPR183/Oxysterol Axis During Dysglycemia Results in Delayed Recruitment of Macrophages to the Lung During Mycobacterium tuberculosis Infection., PMID:35303091
GPR183 Is Dispensable for B1 Cell Accumulation and Function, but Affects B2 Cell Abundance, in the Omentum and Peritoneal Cavity., PMID:35159303
For research use only. Not for human or drug use.
