Catalog No.
YHB50001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Lys286-Gln376
Predicted molecular weight
13.10 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O94966
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Deubiquitinating enzyme 19, Ubiquitin thioesterase 19, KIAA0891, ZMYND9, Ubiquitin carboxyl-terminal hydrolase 19, Ubiquitin-specific-processing protease 19, Zinc finger MYND domain-containing protein 9, USP19
TIPE3 promotes drug resistance in colorectal cancer by enhancing autophagy via the USP19/Beclin1 pathway., PMID:40280943
USP19 deficiency enhances T-cell-mediated antitumor immunity by promoting PD-L1 degradation in colorectal cancer., PMID:40020887
E2F1 activates USP19 to affect the stability of c-Myc to facilitate the progression of hepatocellular carcinoma., PMID:40020513
Enhanced secretion of the amyotrophic lateral sclerosis ALS-associated misfolded TDP-43 mediated by the ER-ubiquitin specific peptidase USP19., PMID:39948244
USP19 potentiates autophagic cell death via inhibiting mTOR pathway through deubiquitinating NEK9 in pancreatic cancer., PMID:39627360
Suppression of Hepatocyte Ferroptosis via USP19-Mediated Deubiquitination of SLC7A11 in Ischemia-Free Liver Transplantation., PMID:39574305
Proteomic Characterization of Ubiquitin Carboxyl-Terminal Hydrolase 19 Deficient Cells Reveals a Role for USP19 in the Secretion of Lysosomal Proteins., PMID:39389361
USP19 exerts a tumor-promoting role in diffuse large B cell lymphoma through stabilizing PARK7., PMID:39240655
USP19 Stabilizes TAK1 to Regulate High Glucose/Free Fatty Acid-induced Dysfunction in HK-2 Cells., PMID:38967891
Deubiquitinating Enzyme USP19 Regulates Ferroptosis and Mitochondrial Damage in SH-SY5Y Cells by Targeting the NOX4 Protein., PMID:38943386
The contribution and mechanism of hypoxia/USP19/Beclin-1 feed-forward loop in cervical cancer., PMID:38773770
Deubiquitinases in muscle physiology and disorders., PMID:38716888
USP19 regulates DNA methylation damage repair and confers temozolomide resistance through MGMT stabilization., PMID:38644551
Mono-UFMylation promotes misfolding-associated secretion of α-synuclein., PMID:38489364
SIAH1 modulates antiviral immune responses by targeting deubiquitinase USP19., PMID:38483060
USP19 deubiquitinase inactivation regulates α-synuclein ubiquitination and inhibits accumulation of Lewy body-like aggregates in mice., PMID:38017009
The deubiquitinating enzyme USP19 facilitates hepatocellular carcinoma progression through stabilizing YAP., PMID:37832781
Silencing USP19 alleviates cigarette smoke extract-induced mitochondrial dysfunction in BEAS-2B cells by targeting FUNDC1., PMID:37808166
Deubiquitinase USP19 modulates apoptotic calcium release and endoplasmic reticulum stress by deubiquitinating BAG6 in triple negative breast cancer., PMID:37700495
Low-dose LPS alleviates early brain injury after SAH by modulating microglial M1/M2 polarization via USP19/FOXO1/IL-10/IL-10R1 signaling., PMID:37672892
Gastrodin destabilizes survivin and overcomes pemetrexed resistance., PMID:37586466
USP19 Negatively Regulates p53 and Promotes Cervical Cancer Progression., PMID:37572221
Ubiquitin-Specific Proteases (USPs) and Metabolic Disorders., PMID:36834633
Opposing USP19 splice variants in TGF-β signaling and TGF-β-induced epithelial-mesenchymal transition of breast cancer cells., PMID:36646950
Concurrent inactivating mutations and expression losses of RGS2, HNF1A, and CAPN12 candidate tumor suppressor genes in colon cancers., PMID:36566600
Deubiquitinase USP19 extends the residual enzymatic activity of phenylalanine hydroxylase variants., PMID:35987969
Proteasomal Degradation of TRAF2 Mediates Mitochondrial Dysfunction in Doxorubicin-Cardiomyopathy., PMID:35983756
Dual role of deubiquitinating enzyme USP19 regulates mitotic progression and tumorigenesis by stabilizing survivin., PMID:35918893
Emerging Role of Ubiquitin-Specific Protease 19 in Oncogenesis and Cancer Development., PMID:35646888
Activation of the membrane-bound Nrf1 transcription factor by USP19, a ubiquitin-specific protease C-terminally anchored in the endoplasmic reticulum., PMID:35613680
Deubiquitinase USP19 enhances phenylalanine hydroxylase protein stability and its enzymatic activity., PMID:35449354
P53 deficiency affects cholesterol esterification to exacerbate hepatocarcinogenesis., PMID:35398929
Molecular Regulations of FUNDC1 at ER-Mitochondria Contacts Under Hypoxic Stress., PMID:37366511
USP19 exacerbates lipogenesis and colorectal carcinogenesis by stabilizing ME1., PMID:34965422
Differential Regulation of Myocardial E3 Ligases and Deubiquitinases in Ischemic Heart Failure., PMID:34947961
USP19 (ubiquitin specific peptidase 19) promotes TBK1 (TANK-binding kinase 1) degradation via chaperone-mediated autophagy., PMID:34436957
USP19 Suppresses Th17-Driven Pathogenesis in Autoimmunity., PMID:34135062
USP19 promotes hypoxia-induced mitochondrial division via FUNDC1 at ER-mitochondria contact sites., PMID:33978709
USP19 modulates cancer cell migration and invasion and acts as a novel prognostic marker in patients with early breast cancer., PMID:33714979
The Protective Effect of Cyanidin-3-Glucoside on Myocardial Ischemia-Reperfusion Injury through Ferroptosis., PMID:33628391
USP19 suppresses inflammation and promotes M2-like macrophage polarization by manipulating NLRP3 function via autophagy., PMID:33097834
Domain interactions reveal auto-inhibition of the deubiquitinating enzyme USP19 and its activation by HSP90 in the modulation of huntingtin aggregation., PMID:33094816
USP19 Enhances MMP2/MMP9-Mediated Tumorigenesis in Gastric Cancer., PMID:32904569
Ubiquitin-specific protease 19 blunts pathological cardiac hypertrophy via inhibition of the TAK1-dependent pathway., PMID:32798288
Non-genomic mechanisms in the estrogen regulation of glycolytic protein levels in endothelial cells., PMID:32757462
Ubiquitin Proteasome System Activity is Suppressed by Curcumin following Exercise-Induced Muscle Damage in Human Skeletal Muscle., PMID:32701392
Ubiquitin specific peptidase 19 is a prognostic biomarker and affect the proliferation and migration of clear cell renal cell carcinoma., PMID:32236633
Curcumol attenuates liver sinusoidal endothelial cell angiogenesis via regulating Glis-PROX1-HIF-1α in liver fibrosis., PMID:32119185
Regulation of TRIF-mediated innate immune response by K27-linked polyubiquitination and deubiquitination., PMID:31511519
USP19 Inhibits TNF-α- and IL-1β-Triggered NF-κB Activation by Deubiquitinating TAK1., PMID:31127032
For research use only. Not for human or drug use.
