Catalog No.
YHB01501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Arg107
Predicted molecular weight
13.99 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O60826
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Coiled-coil domain-containing protein 22, CCDC22, CXorf37
CCDC22 mutations that impair COMMD binding cause attenuated 3C/Ritscher-Schinzel syndrome., PMID:40448120
Evaluating the clinical utility and strategy of whole-exome sequencing testing for fetuses with increased nuchal translucency., PMID:40381797
Endosomal protein DENND10 promotes developmental competence of neurite extension., PMID:40330880
Changes in the Immune Profile and Chromatin Accessibility of Peripheral Regulatory T Cells in Psoriasis Patients Before and After Treatment With Biologics., PMID:40269508
Commander complex regulates lysosomal function and is implicated in Parkinson's disease risk., PMID:40209002
CCDC22 variants caused X-linked focal epilepsy and focal cortical dysplasia., PMID:39426154
Contrasting Retromer with a Newly Described Retriever in Arabidopsis thaliana., PMID:39273954
Structure and interactions of the endogenous human Commander complex., PMID:38459129
Structural organization of the retriever-CCC endosomal recycling complex., PMID:38062209
Structural Organization of the Retriever-CCC Endosomal Recycling Complex., PMID:37397996
Structural Organization of the Retriever-CCC Endosomal Recycling Complex., PMID:37333304
Structure of the endosomal Commander complex linked to Ritscher-Schinzel syndrome., PMID:37172566
CCDC22 and CCDC93, two potential retriever-interacting proteins, are required for root and root hair growth in Arabidopsis., PMID:36618652
COMMD3-Mediated Endosomal Trafficking of HER2 Inhibits the Progression of Ovarian Carcinoma., PMID:36445330
Expanding the pre- and postnatal phenotype of WASHC5 and CCDC22 -related Ritscher-Schinzel syndromes., PMID:36130690
Clinical diversity and molecular mechanism of VPS35L-associated Ritscher-Schinzel syndrome., PMID:36113987
Delineating the CCDC22-related Ritscher-Schinzel syndrome phenotype in the original family., PMID:36073196
A Joint Model of Random Forest and Artificial Neural Network for the Diagnosis of Endometriosis., PMID:35350240
Commander Complex-A Multifaceted Operator in Intracellular Signaling and Cargo., PMID:34943955
Syntaxin 12 and COMMD3 are new factors that function with VPS33B in the biogenesis of platelet α-granules., PMID:34905616
Expansion of the CCDC22 associated Ritscher-Schinzel/3C syndrome and review of the literature: Should the minimal diagnostic criteria be revised?, PMID:34020006
Regulation of murine copper homeostasis by members of the COMMD protein family., PMID:33262129
[Ritscher-Schinzel syndrome caused by CCDC22 gene mutation: a case report]., PMID:33059814
Retromer is involved in epithelial Na+ channel trafficking., PMID:33017185
Biallelic VPS35L pathogenic variants cause 3C/Ritscher-Schinzel-like syndrome through dysfunction of retriever complex., PMID:31712251
Ancestral reconstruction of protein interaction networks., PMID:31658251
Data mining for traffic information., PMID:31596015
Endosomal PI(3)P regulation by the COMMD/CCDC22/CCDC93 (CCC) complex controls membrane protein recycling., PMID:31537807
Towards a molecular understanding of endosomal trafficking by Retromer and Retriever., PMID:30993794
COMMD10-Guided Phagolysosomal Maturation Promotes Clearance of Staphylococcus aureus in Macrophages., PMID:30959277
Identification of a novel CCDC22 mutation in a patient with severe Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis and aggressive natural killer cell leukemia., PMID:30706328
Proteomic and Biochemical Comparison of the Cellular Interaction Partners of Human VPS33A and VPS33B., PMID:29778605
Endosomal receptor trafficking: Retromer and beyond., PMID:29667289
The COMMD Family Regulates Plasma LDL Levels and Attenuates Atherosclerosis Through Stabilizing the CCC Complex in Endosomal LDLR Trafficking., PMID:29545368
Retriever is a multiprotein complex for retromer-independent endosomal cargo recycling., PMID:28892079
CCDC22 gene polymorphism is associated with advanced stages of endometriosis in a sample of Brazilian women., PMID:28470452
Novel regulators of plasma lipid levels., PMID:28333714
Association between rs2294020 in X-linked CCDC22 and susceptibility to autoimmune diseases with focus on systemic lupus erythematosus., PMID:27888057
FOXP3 rs3761548 polymorphism is associated with tacrolimus-induced acute nephrotoxicity in renal transplant patients., PMID:27747372
CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL., PMID:26965651
Endosomal sorting of Notch receptors through COMMD9-dependent pathways modulates Notch signaling., PMID:26553930
COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A., PMID:25355947
Missense variant in CCDC22 causes X-linked recessive intellectual disability with features of Ritscher-Schinzel/3C syndrome., PMID:24916641
A divergent calponin homology (NN-CH) domain defines a novel family: implications for evolution of ciliary IFT complex B proteins., PMID:24257188
CCDC22 deficiency in humans blunts activation of proinflammatory NF-κB signaling., PMID:23563313
CCDC22: a novel candidate gene for syndromic X-linked intellectual disability., PMID:21826058
For research use only. Not for human or drug use.
