Catalog No.
YHA75001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ile16-Lys104
Predicted molecular weight
22.11 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O43687
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Protein kinase A-anchoring protein 7 isoforms alpha/beta, AKAP-7 isoforms alpha and beta, AKAP 18, AKAP18, AKAP15, AKAP7, A-kinase anchor protein 7 isoforms alpha and beta, PRKA7 isoforms alpha/beta, A-kinase anchor protein 18 kDa
Long AKAP18 isoforms anchor ubiquitin specific proteinases and coordinate calcium reuptake at the sarcoplasmic reticulum., PMID:40449590
Hidden evolutionary constraints dictate the retention of coronavirus accessory genes., PMID:39566499
Protein Kinase A Regulates Platelet Phosphodiesterase 3A through an A-Kinase Anchoring Protein Dependent Manner., PMID:38994957
Recurrent viral capture of cellular phosphodiesterases that antagonize OAS-RNase L., PMID:38277437
Recurrent Viral Capture of Cellular Phosphodiesterases that Antagonize OAS-RNase L., PMID:37745432
Subcellular Propagation of Cardiomyocyte β-Adrenergic Activation of Calcium Uptake Involves Internal β-Receptors and AKAP7., PMID:35620477
A Novel Approach to Link Genetics and Human MRI Identifies AKAP7-Dependent Subicular/Prefrontal Functional Connectivity as Altered in Suicidality., PMID:35340866
AKAP18δ Anchors and Regulates CaMKII Activity at Phospholamban-SERCA2 and RYR., PMID:34814703
Specificity and Mechanism of Coronavirus, Rotavirus, and Mammalian Two-Histidine Phosphoesterases That Antagonize Antiviral Innate Immunity., PMID:34372695
Overexpression of miR-669m inhibits erythroblast differentiation., PMID:32782283
iTRAQ plasma proteomics analysis for candidate biomarkers of type 2 incipient diabetic nephropathy., PMID:31384238
OAS-RNase L innate immune pathway mediates the cytotoxicity of a DNA-demethylating drug., PMID:30814222
Single nucleotide polymorphisms alter kinase anchoring and the subcellular targeting of A-kinase anchoring proteins., PMID:30455320
Identification of a novel member of 2H phosphoesterases, 2',5'-oligoadenylate degrading ribonuclease from the oyster Crassostrea gigas., PMID:30195052
Mechanisms for restraining cAMP-dependent protein kinase revealed by subunit quantitation and cross-linking approaches., PMID:28893983
Peripheral blood AKAP7 expression as an early marker for lymphocyte-mediated post-stroke blood brain barrier disruption., PMID:28446746
Role of plasma membrane-associated AKAPs for the regulation of cardiac IK1 current by protein kinase A., PMID:28331977
Targeted deletion of AKAP7 in dentate granule cells impairs spatial discrimination., PMID:27911261
Malonate in the nucleotide-binding site traps human AKAP18γ/δ in a novel conformational state., PMID:27487922
Crystal structure of the mouse hepatitis virus ns2 phosphodiesterase domain that antagonizes RNase L activation., PMID:26757803
Analysis of AKAP7γ Dimerization., PMID:26417456
Phosphorylation state-dependent interaction between AKAP7δ/γ and phospholamban increases phospholamban phosphorylation., PMID:26027516
Structural basis for 2'-5'-oligoadenylate binding and enzyme activity of a viral RNase L antagonist., PMID:25878106
Murine AKAP7 has a 2',5'-phosphodiesterase domain that can complement an inactive murine coronavirus ns2 gene., PMID:24987090
Scaffold state switching amplifies, accelerates, and insulates protein kinase C signaling., PMID:24302730
Comparative proteomic analysis of neutrophils from patients with microscopic polyangiitis and granulomatosis with polyangiitis., PMID:23911962
Early dynamic transcriptomic changes during preoperative radiotherapy in patients with rectal cancer: a feasibility study., PMID:23745026
Engineering A-kinase anchoring protein (AKAP)-selective regulatory subunits of protein kinase A (PKA) through structure-based phage selection., PMID:23625929
Cardiomyocytes from AKAP7 knockout mice respond normally to adrenergic stimulation., PMID:23035250
Molecular evolution of A-kinase anchoring protein (AKAP)-7: implications in comparative PKA compartmentalization., PMID:22834419
Spatiotemporal regulation of PKC via interactions with AKAP7 isoforms., PMID:22670899
Candidate genes in ocular dominance plasticity., PMID:22347157
AKAP phosphatase complexes in the heart., PMID:21562429
NCI60 cancer cell line panel data and RNAi analysis help identify EAF2 as a modulator of simvastatin and lovastatin response in HCT-116 cells., PMID:21483694
Functional roles of a C-terminal signaling complex of CaV1 channels and A-kinase anchoring protein 15 in brain neurons., PMID:21224388
Deletion of the distal C terminus of CaV1.2 channels leads to loss of beta-adrenergic regulation and heart failure in vivo., PMID:21216955
The large isoforms of A-kinase anchoring protein 18 mediate the phosphorylation of inhibitor-1 by protein kinase A and the inhibition of protein phosphatase 1 activity., PMID:21149637
Molecular mechanism of calcium channel regulation in the fight-or-flight response., PMID:20876873
A-kinase anchoring proteins: getting to the heart of the matter., PMID:20231544
AKAP 18 alpha and gamma have opposing effects on insulin release in INS-1E cells., PMID:19896945
The potential use of AKAP18delta as a drug target in heart failure patients., PMID:18613762
Phosphorylation of the cAMP-dependent protein kinase (PKA) regulatory subunit modulates PKA-AKAP interaction, substrate phosphorylation, and calcium signaling in cardiac cells., PMID:18550536
Chronic beta2-adrenoceptor stimulation impairs cardiac relaxation via reduced SR Ca2+-ATPase protein and activity., PMID:18408128
AKAP complex regulates Ca2+ re-uptake into heart sarcoplasmic reticulum., PMID:17901878
The A-kinase anchoring protein 15 regulates feedback inhibition of the epithelial Na+ channel., PMID:17244820
Spatial organisation of AKAP18 and PDE4 isoforms in renal collecting duct principal cells., PMID:16500722
High-affinity AKAP7delta-protein kinase A interaction yields novel protein kinase A-anchoring disruptor peptides., PMID:16483255
Identification of a novel A-kinase anchoring protein 18 isoform and evidence for its role in the vasopressin-induced aquaporin-2 shuttle in renal principal cells., PMID:15037626
Beta-adrenergic regulation requires direct anchoring of PKA to cardiac CaV1.2 channels via a leucine zipper interaction with A kinase-anchoring protein 15., PMID:14569017
AKAP7gamma is a nuclear RI-binding AKAP., PMID:12804576
For research use only. Not for human or drug use.
