Catalog No.
YHA61501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser68-Pro324
Predicted molecular weight
30.91 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O43255
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
RING-type E3 ubiquitin transferase SIAH2, SIAH2, hSiah2, Seven in absentia homolog 2, Siah-2, E3 ubiquitin-protein ligase SIAH2
Integrative immunology identified interferome signatures in uveitis and systemic disease-associated uveitis., PMID:40270958
Integrating network pharmacology and in vivo pharmacological validation to explore the gastroprotective mechanism of Sotetsuflavone against indomethacin-induced gastric ulcer in rats: Involvement of JAK2/STAT3 pathway., PMID:40258498
A Novel Prognostic Signature of Mitophagy-Related E3 Ubiquitin Ligases in Breast Cancer., PMID:40004017
RING dimerisation drives higher-order organisation of SINA/SIAH E3 ubiquitin ligases., PMID:39910688
The E3-ligase Siah2 activates mitochondrial quality control in neurons to maintain energy metabolism during ischemic brain tolerance., PMID:39875361
Cold atmospheric plasma potentiates ferroptosis via EGFR(Y1068)-mediated dual axes on GPX4 among triple negative breast cancer cells., PMID:39781456
Siah2 antagonism of Pard3/JamC modulates Ntn1-Dcc signaling to regulate cerebellar granule neuron germinal zone exit., PMID:39774925
Aldehyde dehydrogenase 2 attenuates renal injury through inhibiting CYP4A expression., PMID:39746575
Virtual Screening, Molecular Dynamics, and Mechanism Study of Homeodomain-Interacting Protein Kinase 2 Inhibitor in Renal Fibroblasts., PMID:39598332
Antagonistic action of Siah2 and Pard3/JamC to promote germinal zone exit of differentiated cerebellar granule neurons by modulating Ntn1 signaling via Dcc., PMID:39399669
SIAH3 is frequently epigenetically silenced in cancer and regulates mitochondrial metabolism., PMID:39344659
Siah2- and LRSAM1-mediated K63-linked ubiquitination of snakehead vesiculovirus nucleoprotein facilitates viral replication., PMID:38842318
SIAH2-Mediated Degradation of ACSL4 Inhibits the Anti-Tumor Activity of CD8+ T Cells in Hepatocellular Carcinoma., PMID:38842200
SIAH2 suppresses c-JUN pathway by promoting the polyubiquitination and degradation of HBx in hepatocellular carcinoma., PMID:38842124
Dexmedetomidine promotes colorectal cancer progression via Piwil2 signaling., PMID:38592610
LATS2 degradation promoted fibrosis damage and rescued by vitamin K3 in lupus nephritis., PMID:38459604
YTHDF1 enhances stemness and chemoresistance in triple-negative breast cancer cells by upregulating SIAH2., PMID:37983722
HMGB1-induced activation of ER stress contributes to pulmonary artery hypertension in vitro and in vivo., PMID:37268944
Methylene blue targets PHD3 expression in murine microglia to mitigate lipopolysaccharide-induced neuroinflammation and neurocognitive impairments., PMID:37210913
Lysine-independent ubiquitination and degradation of REV-ERBα involves a bi-functional degradation control sequence at its N-terminus., PMID:37205588
Ubiquitin Ligases Siah1a/2 Control Alveolar Macrophage Functions to Limit Carcinogen-Induced Lung Adenocarcinoma., PMID:37078793
Proteasome Inhibitors Silence Oncogenes in Multiple Myeloma through Localized Histone Deacetylase 3 (HDAC3) Stabilization and Chromatin Condensation., PMID:36846090
CBX2-mediated suppression of SIAH2 triggers WNK1 accumulations to promote glycolysis in hepatocellular carcinoma., PMID:36780970
Profiling of a novel circadian clock-related prognostic signature and its role in immune function and response to molecular targeted therapy in pancreatic cancer., PMID:36626244
Nrf2 and Parkin-Hsc70 regulate the expression and protein stability of p62/SQSTM1 under hypoxia., PMID:36481701
Timed use of digoxin prevents heart ischemia-reperfusion injury through a REV-ERBα-UPS signaling pathway., PMID:38229609
SIAH proteins regulate the degradation and intra-mitochondrial aggregation of PINK1: Implications for mitochondrial pathology in Parkinson's disease., PMID:36307912
Methods to Evaluate the Effects of HAT/KAT Inhibition on SIAH2-Driven Reactive Oxygen Species Generation in Helicobacter pylori-Infected Gastric Epithelial Cells., PMID:36255634
Correlation between Ubiquitin E3 Ligases (SIAHs) and Heat Shock Protein 90 in Breast Cancer Patients., PMID:36249118
Hyperthermia promotes degradation of the acute promyelocytic leukemia driver oncoprotein ZBTB16/RARα., PMID:36216898
SIAH2 regulates DNA end resection and replication fork recovery by promoting CtIP ubiquitination., PMID:36155803
Delving into the Heterogeneity of Different Breast Cancer Subtypes and the Prognostic Models Utilizing scRNA-Seq and Bulk RNA-Seq., PMID:36077333
Modulating the Siah2-PHD3-HIF1α axis and/or autophagy potentially retard colon cancer proliferation possibly, due to the damping of colon cancer stem cells., PMID:35994813
SIAH2 regulates colorectal cancer tumorigenesis via PI3K/ATK signaling pathway., PMID:35926257
Hypoxia-induced proteasomal degradation of DBC1 by SIAH2 in breast cancer progression., PMID:35913115
Siah2-GRP78 interaction regulates ROS and provides a proliferative advantage to Helicobacter pylori-infected gastric epithelial cancer cells., PMID:35816252
Yu-Ping-Feng Formula Ameliorates Alveolar-Capillary Barrier Injury Induced by Exhausted-Exercise via Regulation of Cytoskeleton., PMID:35814249
"The ubiquitin ligase SIAH2 is a female-specific regulator of circadian rhythms and metabolism"., PMID:35789210
P-TEFb is degraded by Siah1/2 in quiescent cells., PMID:35524561
Expression of the preadipocyte marker ZFP423 is dysregulated between well-differentiated and dedifferentiated liposarcoma., PMID:35313831
SIAH ubiquitin E3 ligases as modulators of inflammatory gene expression., PMID:35284677
Construction of a circRNA-miRNA-mRNA Regulatory Network for Coronary Artery Disease by Bioinformatics Analysis., PMID:35223093
Decreased Expression of Programmed Death Ligand-L1 by Seven in Absentia Homolog 2 in Cholangiocarcinoma Enhances T-Cell-Mediated Antitumor Activity., PMID:35154166
BoxCar and shotgun proteomic analyses reveal molecular networks regulated by UBR5 in prostate cancer., PMID:34897998
Ochratoxin A Induces Steatosis via PPARγ-CD36 Axis., PMID:34822586
The role of Siah2 in tumorigenesis and cancer therapy., PMID:34687788
Hyperthermia Selectively Destabilizes Oncogenic Fusion Proteins., PMID:34661159
Identification of differentially expressed genes and pathways crosstalk analysis in Rheumatoid and Osteoarthritis using next-generation sequencing and protein-protein networks., PMID:34354452
Construction and Analysis of the Dysregulated ceRNA Network and Identification of Risk Long Noncoding RNAs in Breast Cancer., PMID:34149805
Targeting ADT-Induced Activation of the E3 Ubiquitin Ligase Siah2 to Delay the Occurrence of Castration-Resistant Prostate Cancer., PMID:33937036
For research use only. Not for human or drug use.
