Catalog No.
YVV24101
Expression system
E. coli
Species
Influenza A virus (A/New York/312/2001 (H1N1))
Protein length
Glu2-Gly209
Predicted molecular weight
36.86 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
ACN39337.1
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
polymerase PA, partial, PA
KRT6A Restricts Influenza A Virus Replication by Inhibiting the Nuclear Import and Assembly of Viral Ribonucleoprotein Complex., PMID:40431683
Molecular basis of influenza ribonucleoprotein complex assembly and processive RNA synthesis., PMID:40373132
Novel benzamide derivatives with indole moiety as dual-target antiviral agents: Rational design, efficient synthesis, and potent anti-influenza activity through concurrent binding to PAC terminal domain and viral nucleoprotein., PMID:40367674
Influenza virus: Genomic insights, evolution, and its clinical presentation., PMID:40345348
Impact of the polymerase acidic protein E199K substitution in influenza A viruses on baloxavir susceptibility., PMID:40324596
Multiple antiviral mechanisms of Ephedrae Herba and Cinnamomi Cortex against influenza: inhibition of entry and replication., PMID:40304468
Synergistic effects of PA (S184N) and PB2 (E627K) mutations on the increased pathogenicity of H3N2 canine influenza virus infections in mice and dogs., PMID:40183583
PA and PA-X: two key proteins from segment 3 of the influenza viruses., PMID:40160474
Jinxin oral liquid reduced lung inflammation in influenza A virus infected mice through inhibiting NOD-like receptor protein 3 pathway., PMID:40151115
Restriction of influenza A virus replication by host DCAF7-CRL4B axis., PMID:40145735
Cross-species and mammal-to-mammal transmission of clade 2.3.4.4b highly pathogenic avian influenza A/H5N1 with PB2 adaptations., PMID:40044729
Designing a multi-epitope vaccine candidate against pandemic influenza a virus: an immunoinformatics and structural vaccinology approach., PMID:39921843
Phosphorylation of PA at serine 225 enhances viral fitness of the highly pathogenic H5N1 avian influenza virus in mice., PMID:39847871
PB2 and PA mutations contribute to the pathogenicity of mouse-adapted pdmH1N1-Venus reporter influenza A virus in a mammalian model., PMID:39839124
High-resolution melting analysis for detection of nucleotide mutation markers in the polymerase-acidic (PA) gene of influenza virus that are associated with baloxavir marboxil resistance., PMID:39762649
The PA-X host shutoff site 100 V exerts a contrary effect on viral fitness of the highly pathogenic H7N9 influenza A virus in mice and chickens., PMID:39731774
Effect of pandemic influenza A virus PB1 genes of avian origin on viral RNA polymerase activity and pathogenicity., PMID:39671482
Discovery of Novel Thiophene-Based Baloxavir Derivatives as Potent Cap-Dependent Endonuclease Inhibitors for Influenza Treatment., PMID:39658517
Marked neurotropism and potential adaptation of H5N1 clade 2.3.4.4.b virus in naturally infected domestic cats., PMID:39648950
Chicken ANP32A-independent replication of highly pathogenic avian influenza viruses potentially leads to mammalian adaptation-related amino acid substitutions in viral PB2 and PA proteins., PMID:39570060
Structural insights into Influenza A virus RNA polymerase PB1 binding to nuclear import host factor RanBP5., PMID:39536408
TRIM46 accelerates H1N1 influenza virus-induced ferroptosis and inflammatory response by regulating SLC7A11 ubiquitination., PMID:39531094
Hemagglutination-Inhibition Antibodies and Protection against Influenza Elicited by Inactivated and Live Attenuated Vaccines in Children., PMID:39504434
Study on the activity and mechanism of herbal formula anti-infection powder (AIP) against influenza-virus-induced pneumonia through genetic susceptibility genes., PMID:39426575
Synthesis and anti-influenza virus activity of substituted dibenzoxepine-based baloxavir derivatives., PMID:39388905
Continuing evolution of H5N1 highly pathogenic avian influenza viruses of clade 2.3.2.1a G2 genotype in domestic poultry of Bangladesh during 2018-2021., PMID:39382006
H5N1 clade 2.3.4.4b dynamics in experimentally infected calves and cows., PMID:39321846
Two amino acid residues in the N-terminal region of the polymerase acidic protein determine the virulence of Eurasian avian-like H1N1 swine influenza viruses in mice., PMID:39212447
Optimization of potent, broad-spectrum, and specific anti-influenza compounds targeting RNA polymerase PA-PB1 heterodimerization., PMID:39153334
The PB2 I714S mutation influenced mammalian adaptation of the H3N2 canine influenza virus by interfering with nuclear import efficiency and RNP complex assembly., PMID:39139051
Synergistic activity of an RNA polymerase PA-PB1 interaction inhibitor with oseltamivir against human and avian influenza viruses in cell culture and in ovo., PMID:39117284
High throughput profiling identified PA-L106R amino acid substitution in A(H1N1)pdm09 influenza virus that confers reduced susceptibility to baloxavir in vitro., PMID:39002800
Genotypic and phenotypic susceptibility of emerging avian influenza A viruses to neuraminidase and cap-dependent endonuclease inhibitors., PMID:38986873
Amino acid mutations PB1-V719M and PA-N444D combined with PB2-627K contribute to the pathogenicity of H7N9 in mice., PMID:38970119
Detection of influenza A(H3N2) viruses with polymerase acidic subunit substitutions after and prior to baloxavir marboxil treatment during the 2022-2023 influenza season in Japan., PMID:38969237
Antiviral activity of intracellular nanobodies targeting the influenza virus RNA-polymerase core., PMID:38875296
Novel Acyl Thiourea-Based Hydrophobic Tagging Degraders Exert Potent Anti-Influenza Activity through Two Distinct Endonuclease Polymerase Acidic-Targeted Degradation Pathways., PMID:38775356
Structures of H5N1 influenza polymerase with ANP32B reveal mechanisms of genome replication and host adaptation., PMID:38750014
The mitochondrial carrier homolog 2 is involved in down-regulation of influenza A virus replication., PMID:38727866
Humoral Correlates of Protection Against Influenza A/H3N2 Virus Infection., PMID:38723107
Exploration of influenza A virus PA protein-associated cellular proteins discloses its impact on mitochondrial function., PMID:38719025
Influenza A virus NS1 effector domain is required for PA-X-mediated host shutoff in infected cells., PMID:38629840
Molecular characterization of the whole genome of H9N2 avian influenza virus isolated from Egyptian poultry farms., PMID:38625394
Influenza C virus susceptibility to antivirals with different mechanisms of action., PMID:38587392
Structural and functional characterization of the interaction between the influenza A virus RNA polymerase and the CTD of host RNA polymerase II., PMID:38563748
Amino acids in the polymerase complex of shorebird-isolated H1N1 influenza virus impact replication and host-virus interactions in mammalian models., PMID:38517705
Chicken UFL1 Restricts Avian Influenza Virus Replication by Disrupting the Viral Polymerase Complex and Facilitating Type I IFN Production., PMID:38477617
Virological and clinical outcomes in outpatients treated with baloxavir or neuraminidase inhibitors for A(H3N2) influenza: A multicenter study of the 2022-2023 season., PMID:38430970
Multiplexed Capillary-Flow Driven Immunoassay for Respiratory Illnesses., PMID:38417100
Comparative examination of a rapid immunocytochemical test for the detection of highly pathogenic avian influenza virus in domestic birds in field outbreaks., PMID:38372250
For research use only. Not for human or drug use.
