Catalog No.
YVV20201
Expression system
E. coli
Species
Human rotavirus A
Protein length
Leu15-Leu173
Predicted molecular weight
21 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
E9BVI4
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Outer capsid protein VP4, VP4
A rotavirus VP4 or VP7 monoreassortant panel identifies genotypes that are less susceptible to neutralization by systemic antibodies induced by vaccination or natural infection., PMID:40444468
Equine Rotavirus A Outbreaks in Ireland (2023-2024): An Epidemiological Investigation and Virus Genotyping., PMID:40284954
Extended analyses of rotavirus C (RVC) G-types and P-types reveal new cut-off value for the G-types and reclassification of strains., PMID:40231817
Analysis of protein determinants of genotype-specific properties of group a rotaviruses using machine learning., PMID:40203739
Immunoinformatics-driven design of a multi-epitope vaccine targeting neonatal rotavirus with focus on outer capsid proteins VP4 and VP7 and non structural proteins NSP2 and NSP5., PMID:40195509
Truncated rotavirus VP4 proteins induce stronger protective immunity compared to P2 - VP8 in animal models., PMID:40194664
VP4-Specific IgA level as a correlate of neutralizing antibody and fecal shedding of porcine rotavirus infection., PMID:40179488
14 years of rotavirus A surveillance: unusual dominance of equine-like G3P[8] genotype with DS-1-like genotype constellation after the pandemic, Belgium, 2009 to 2023., PMID:40156349
Breast milk delivery of an engineered dimeric IgA protects neonates against rotavirus., PMID:39842610
A single residue switch mediates the broad neutralization of Rotaviruses., PMID:39833145
A matched case-control study of porcine group A and C rotaviruses in a swine farrowing production system., PMID:39765009
Epidemiology of viral gastroenteritis in children and genetic diversity of rotavirus strains in Kolkata, West Bengal after introduction of rotavirus vaccine., PMID:39731817
Epidemiological, molecular, and evolutionary characteristics of G1P[8] rotavirus in China on the eve of RotaTeq application., PMID:39717546
Unusual G9P[4] Rotavirus Emerged After the Dynamic Changes in Rotavirus Genotypes From Equine-Like G3 to Typical Human G1/G3 in Indonesia., PMID:39670413
Establishment of a Reverse Genetics System for Rotavirus Vaccine Strain LLR and Developing Vaccine Candidates Carrying VP7 Gene Cloned From Human Strains Circulating in China., PMID:39610277
New Genotype G3 P[8] of Rotavirus Identified in a Mexican Gastroenteric Rabbit., PMID:39599844
Whole Genome Sequences of the Wildtype AU-1 Rotavirus A Strain: The Prototype of the AU-1-like Genotype Constellation., PMID:39459863
A first report of rotavirus B from Zambian pigs leading to the discovery of a novel VP4 genotype P[9]., PMID:39449113
Chimeric Viruses Enable Study of Antibody Responses to Human Rotaviruses in Mice., PMID:39066309
Reverse vaccinology-based multi-epitope vaccine design against Indian group A rotavirus targeting VP7, VP4, and VP6 proteins., PMID:38960216
Human Rotaviruses of Multiple Genotypes Acquire Conserved VP4 Mutations during Serial Passage., PMID:38932271
Epidemiological Characteristics and Genotypic Features of Rotavirus and Norovirus in Jining City, 2021-2022., PMID:38932216
Specific binding sites on Rhesus rotavirus capsid protein dictate the method of endocytosis inducing the murine model of biliary atresia., PMID:38860860
The synergy of recombinant NSP4 and VP4 from porcine rotavirus elicited a strong mucosal response., PMID:38850894
Reverse Genetics of Murine Rotavirus: A Comparative Analysis of the Wild-Type and Cell-Culture-Adapted Murine Rotavirus VP4 in Replication and Virulence in Neonatal Mice., PMID:38793648
Antigenic epitope analysis of Pakistani G3 and G9 rotavirus strains compared to vaccine strains revealed multiple amino acid differences., PMID:38759540
VP4 Mutation Boosts Replication of Recombinant Human/Simian Rotavirus in Cell Culture., PMID:38675907
Wa-VP4* as a candidate rotavirus vaccine induced homologous and heterologous virus neutralizing antibody responses in mice, pigs, and cynomolgus monkeys., PMID:38670845
Recombinant bivalent subunit vaccine combining truncated VP4 from P[7] and P[23] induces protective immunity against prevalent porcine rotaviruses., PMID:38591886
The rotavirus VP5*/VP8* conformational transition permeabilizes membranes to Ca2., PMID:38574119
Emergence and dissemination of equine-like G3P[8] rotavirus A in Brazil between 2015 and 2021., PMID:38451227
Identification of a novel intra-genotype reassortant G1P[8] rotavirus in Italy, 2021., PMID:38307378
Lactobacillus acidophilus Expressing Murine Rotavirus VP8 and Mucosal Adjuvants Induce Virus-Specific Immune Responses., PMID:38140179
Interaction of species A rotavirus VP4 with the cellular proteins vimentin and actin related protein 2 discovered by a proximity interactome assay., PMID:37991368
Genotype analysis of rotaviruses isolated from children during a phase III clinical trial with the hexavalent rotavirus vaccine in China., PMID:37972894
The rotavirus VP5*/VP8* conformational transition permeabilizes membranes to Ca2., PMID:37905109
Genotypic shift in rotavirus associated with neonatal outbreaks in Seoul, Korea., PMID:37253299
A multidisciplinary approach to the identification of the protein-RNA connectome in double-stranded RNA virus capsids., PMID:37070191
Co-Surveillance of Rotaviruses in Humans and Domestic Animals in Central Uganda Reveals Circulation of Wide Genotype Diversity in the Animals., PMID:36992447
Strain-Specific Interactions between the Viral Capsid Proteins VP4, VP7 and VP6 Influence Rescue of Rotavirus Reassortants by Reverse Genetics., PMID:36982745
Evaluation of Some Benzo[g]Quinazoline Derivatives as Antiviral Agents against Human Rotavirus Wa Strain: Biological Screening and Docking Study., PMID:36975526
A reverse genetics system for human rotavirus G2P[4]., PMID:36748482
Vaccine evaluation and genotype characterization in children infected with rotavirus in Qatar., PMID:36658331
Characterization of Sialic Acid-Independent Simian Rotavirus Mutants in Viral Infection and Pathogenesis., PMID:36602365
Global Infection Rate of Rotavirus C during 1980-2022 and Analysis of Critical Factors in the Host Range Restriction of Virus VP4., PMID:36560830
The Association between Symptomatic Rotavirus Infection and Histo-Blood Group Antigens in Young Children with Diarrhea in Pretoria, South Africa., PMID:36560739
Generation and characterization of mouse monoclonal antibodies against the VP4 protein of group A human rotaviruses., PMID:36152816
Human rotavirus VP4 and VP7 genetic diversity and detection of GII norovirus in Ibadan as Nigeria introduces rotavirus vaccine., PMID:36138570
Phylogenetic analysis of the viral proteins VP4/VP7 of circulating human rotavirus strains in China from 2016 to 2019 and comparison of their antigenic epitopes with those of vaccine strains., PMID:36004332
Rotavirus Spike Protein VP4 Mediates Viroplasm Assembly by Association to Actin Filaments., PMID:35938869
For research use only. Not for human or drug use.
