Catalog No.
YXX15001
Expression system
E. coli
Species
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Protein length
Met1-Phe100
Predicted molecular weight
11.62 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P9WNK5
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
ESAT-6-like protein EsxB, 10 kDa culture filtrate antigen CFP-10, CFP-10, Secreted antigenic protein MTSA-10, esxB, cfp10, lhp, mtsA10, Rv3874, MTV027.09
Exploring the Molecular Intersection of Posterior Ocular Tuberculosis: Mycobacterium tuberculosis Proteins, Ocular Autoimmunity, and Immune Receptor Interactions., PMID:40151358
Functional Analysis of Promoters, mRNA Cleavage, and mRNA Secondary Structure on esxB-esxA in Mycolicibacterium smegmatis., PMID:39770301
Mycobacterium bovis mutant in the virulence factors PhoP, ESAT-6 and CFP-10 persisted in mouse organs after a year post-vaccination., PMID:39509845
The regulatory functions of ESX-1 substrates, EspE and EspF, are separable from secretion., PMID:39136451
The Presence of esat-6 and cfp10 and Other Gene Orthologs of the RD 1 Region in Non-Tuberculous Mycobacteria, Mycolicibacteria, Mycobacteroides and Mycolicibacter as Possible Impediments for the Diagnosis of (Animal) Tuberculosis., PMID:38930534
Analysis of the components of Mycobacterium tuberculosis heat-resistant antigen (Mtb-HAg) and its regulation of γδ T-cell function., PMID:38741147
Mycobacterium tuberculosis inhibits METTL14-mediated m6A methylation of Nox2 mRNA and suppresses anti-TB immunity., PMID:38548762
Live attenuated Mycobacterium bovis strains combined with the encapsulated H65 antigen as a vaccine strategy against bovine tuberculosis in a mouse model., PMID:38335676
Discovery of dual-active ethionamide boosters inhibiting the Mycobacterium tuberculosis ESX-1 secretion system., PMID:38181799
Antibody reactivity to Mycobacterium tuberculosis-specific regions of differences 1 and regions of differences 9 proteins and peptides in rabbits, mice, and humans., PMID:38149542
Chemical and Biological Characterization of Mycobacterium Tuberculosis-Specific ESAT6-Like Proteins and their Potentials in the Prevention of Tuberculosis and Asthma., PMID:37703836
Multi-omics-based characterization of the influences of Mycobacterium tuberculosis virulence factors EsxB and PPE68 on host cells., PMID:37162591
Development of Gold-Nanoparticle-Based Lateral Flow Immunoassays for Rapid Detection of TB ESAT-6 and CFP-10., PMID:36979566
Uptake-independent killing of macrophages by extracellular Mycobacterium tuberculosis aggregates., PMID:36920246
Listeria-vectored multi-antigenic tuberculosis vaccine protects C57BL/6 and BALB/c mice and guinea pigs against Mycobacterium tuberculosis challenge., PMID:36539517
Differential activation of innate and adaptive lymphocytes during latent or active infection with Mycobacterium tuberculosis., PMID:35856253
Listeria-Vectored Multiantigenic Tuberculosis Vaccine Enhances Protective Immunity against Aerosol Challenge with Virulent Mycobacterium tuberculosis in BCG-Immunized C57BL/6 and BALB/c Mice., PMID:35642945
Early secreted antigenic target of 6 kda-like proteins of mycobacterium tuberculosis: Diagnostic and vaccine relevance., PMID:35295018
A Fluorescence Dequenching-based Liposome Leakage Assay to Measure Membrane Permeabilization by Pore-forming Proteins., PMID:34150932
Label-Free Comparative Proteomics of Differentially Expressed Mycobacterium tuberculosis Protein in Rifampicin-Related Drug-Resistant Strains., PMID:34063426
A comparative investigation on the role and interaction of EsxA and EsxB in host immune response., PMID:33691174
Post-translational knockdown and post-secretional modification of EsxA determine contribution of EsxA membrane permeabilizing activity for mycobacterial intracellular survival., PMID:33356823
Conserved ESX-1 Substrates EspE and EspF Are Virulence Factors That Regulate Gene Expression., PMID:32900815
High resolution CryoEM structure of the ring-shaped virulence factor EspB from Mycobacterium tuberculosis., PMID:32875288
The ESX-1 Virulence Factors Downregulate miR-147-3p in Mycobacterium marinum-Infected Macrophages., PMID:32253249
Modification of a PE/PPE substrate pair reroutes an Esx substrate pair from the mycobacterial ESX-1 type VII secretion system to the ESX-5 system., PMID:32184351
Nα-Acetylation of the virulence factor EsxA is required for mycobacterial cytosolic translocation and virulence., PMID:32169899
The effect of adjuvants and delivery systems on Th1, Th2, Th17 and Treg cytokine responses in mice immunized with Mycobacterium tuberculosis-specific proteins., PMID:32027660
Substrate Interaction with the EssC Coupling Protein of the Type VIIb Secretion System., PMID:31964696
Structural insights into substrate recognition by the type VII secretion system., PMID:31758528
Coordinate regulation of virulence and metabolic genes by the transcription factor HbhR in Mycobacterium marinum., PMID:31587365
Morphology-based classification of mycobacteria-infected macrophages with convolutional neural network: reveal EsxA-induced morphologic changes indistinguishable by naked eyes., PMID:31287998
ESX Secretion-Associated Protein C From Mycobacterium tuberculosis Induces Macrophage Activation Through the Toll-Like Receptor-4/Mitogen-Activated Protein Kinase Signaling Pathway., PMID:31134163
Mycobacterium marinum down-regulates miR-148a in macrophages in an EsxA-dependent manner., PMID:31078924
Mycobacteria-Specific T Cells May Be Expanded From Healthy Donors and Are Near Absent in Primary Immunodeficiency Disorders., PMID:30984189
EspH is a hypervirulence factor for Mycobacterium marinum and essential for the secretion of the ESX-1 substrates EspE and EspF., PMID:30102741
Mycobacterium bovis ESAT-6, CFP-10 and EspC antigens show high conservation among field isolates., PMID:30029900
Immuno Nanosensor for the Ultrasensitive Naked Eye Detection of Tuberculosis., PMID:29899214
Non-tuberculous Mycobacterium species causing mycobacteriosis in farmed aquatic animals of South Africa., PMID:29653505
Esx Paralogs Are Functionally Equivalent to ESX-1 Proteins but Are Dispensable for Virulence in Mycobacterium marinum., PMID:29555701
Potential of High-Affinity, Slow Off-Rate Modified Aptamer Reagents for Mycobacterium tuberculosis Proteins as Tools for Infection Models and Diagnostic Applications., PMID:28794178
Humoral immune responses in mice immunized with region of difference DNA vaccine constructs of pUMVC6 and pUMVC7., PMID:28776528
Immunogenicity and Protective Efficacy of a Fusion Protein Tuberculosis Vaccine Combining Five Esx Family Proteins., PMID:28620588
The Bioinformatics Analysis of Comparative Genomics of Mycobacterium tuberculosis Complex (MTBC) Provides Insight into Dissimilarities between Intraspecific Groups Differing in Host Association, Virulence, and Epitope Diversity., PMID:28377903
EspC forms a filamentous structure in the cell envelope of Mycobacterium tuberculosis and impacts ESX-1 secretion., PMID:27859904
Discovery of the type VII ESX-1 secretion needle?, PMID:27859892
Secretome profiling of highly virulent Mycobacterium bovis 04-303 strain reveals higher abundance of virulence-associated proteins., PMID:27769937
EsxA membrane-permeabilizing activity plays a key role in mycobacterial cytosolic translocation and virulence: effects of single-residue mutations at glutamine 5., PMID:27600772
Comparative Genomics and Proteomic Analysis of Four Non-tuberculous Mycobacterium Species and Mycobacterium tuberculosis Complex: Occurrence of Shared Immunogenic Proteins., PMID:27375559
Phosphate starvation: a novel signal that triggers ESX-5 secretion in Mycobacterium tuberculosis., PMID:26800324
For research use only. Not for human or drug use.
