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Research Grade Tralokinumab

Catalog #:   DHE07703 Specific References (100) DATASHEET
Host species: Human
Isotype: IgG4-lambda
Applications: Research Grade Biosimilar
Expression system: Mammalian Cells
Overview

Catalog No.

DHE07703

Expression system

Mammalian Cells

Species reactivity

Human

Host species

Human

Isotype

IgG4-lambda

Clonality

Monoclonal

Target

IL13, NC30, Interleukin-13, IL-13

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P35225

Applications

Research Grade Biosimilar

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Alternative Names

CAT-354, CAS: 1044515-88-9

Clone ID

Tralokinumab

Data Image
  • Bioactivity
    Detects Human IL13 in indirect ELISAs.
  • SDS-PAGE
    SDS PAGE for Tralokinumab
  • SEC-HPLC
    The purity of this product is >95% as determined by SEC-HPLC.
References

A Phase 2 Randomized Controlled Study of Tralokinumab in Subjects with Idiopathic Pulmonary Fibrosis, PMID: 28787186

A phase II placebo-controlled study of tralokinumab in moderate-to-severe asthma, PMID: 22743678

A randomized, placebo-controlled, single ascending-dose study to assess the safety, tolerability, pharmacokinetics, and immunogenicity of subcutaneous tralokinumab in Japanese healthy volunteers, PMID: 29622380

Application of structured statistical analyses to identify a biomarker predictive of enhanced tralokinumab efficacy in phase III clinical trials for severe, uncontrolled asthma, PMID: 31315668

Are Biologics Efficacious in Atopic Dermatitis? A Systematic Review and Meta-Analysis, PMID: 29098604

Biological therapies for atopic dermatitis: An update, PMID: 30679974

Biological Therapies of Severe Asthma and Their Possible Effects on Airway Remodeling, PMID: 32625205

Biologics for Atopic Dermatitis, PMID: 33012322

Commonality of the IL-4/IL-13 pathway in atopic diseases, PMID: 28277826

Current and emerging biologics for the treatment of pediatric atopic dermatitis, PMID: 33078990

Docking analysis and the possibility of prediction efficacy for an anti-IL-13 biopharmaceutical treatment with tralokinumab and lebrikizumab for bronchial asthma, PMID: 29155876

Dose-Exposure-Response Relationship of the Investigational Anti-Interleukin-13 Monoclonal Antibody Tralokinumab in Patients With Severe, Uncontrolled Asthma, PMID: 28758192

Effect of monoclonal antibody drug therapy on mucosal biomarkers in airway disease: A systematic review, PMID: 32808380

Effect of tralokinumab, an interleukin-13 neutralising monoclonal antibody, on eosinophilic airway inflammation in uncontrolled moderate-to-severe asthma (MESOS): a multicentre, double-blind, randomised, placebo-controlled phase 2 trial, PMID: 29793857

Efficacy and safety of tralokinumab in patients with severe uncontrolled asthma: a randomised, double-blind, placebo-controlled, phase 2b trial, PMID: 26231288

Efficacy of biologics in atopic dermatitis, PMID: 32003247

Emerging Treatment Options in Atopic Dermatitis: Systemic Therapies, PMID: 29320765

Evaluation of Antibody Properties and Clinically Relevant Immunogenicity, Anaphylaxis, and Hypersensitivity Reactions in Two Phase III Trials of Tralokinumab in Severe, Uncontrolled Asthma, PMID: 30649752

Health-related quality of life with tralokinumab in moderate-to-severe atopic dermatitis: A phase 2b randomized study, PMID: 33333295

Innovation in Atopic Dermatitis: From Pathogenesis to Treatment, PMID: 31964499

Monoclonal antibodies in type 2 asthma: a systematic review and network meta-analysis, PMID: 31395084

New and Emerging Systemic Treatments for Atopic Dermatitis, PMID: 32519223

New and Emerging Therapies for Pediatric Atopic Dermatitis, PMID: 31364023

New Anti-Eosinophil Drugs for Asthma and COPD: Targeting the Trait!, PMID: 28583618

Novel Therapeutic Approaches and Targets for the Treatment of Atopic Dermatitis, PMID: 32525769

Pharmacokinetics of tralokinumab in adolescents with asthma: implications for future dosing, PMID: 26182954

Probiotics for treating eczema, PMID: 30480774

Relative efficacy of systemic treatments for atopic dermatitis, PMID: 30296535

Structural Characterisation Reveals Mechanism of IL-13-Neutralising Monoclonal Antibody Tralokinumab as Inhibition of Binding to IL-13Rα1 and IL-13Rα2, PMID: 27956146

The Changing Landscape of Alopecia Areata: The Therapeutic Paradigm, PMID: 28646393

The IL-13-OVOL1-FLG axis in atopic dermatitis, PMID: 31509236

The Safety and Efficacy of Anti-IL-13 Treatment with Tralokinumab (CAT-354) in Moderate to Severe Asthma: A Systematic Review and Meta-Analysis, PMID: 31152798

The tralokinumab story: Nothing is ever simple, PMID: 30659852

Tralokinumab did not demonstrate oral corticosteroid-sparing effects in severe asthma, PMID: 30442714

Tralokinumab does not impact vaccine-induced immune responses: Results from a 30-week, randomized, placebo-controlled trial in adults with moderate-to-severe atopic dermatitis, PMID: 33744356

Tralokinumab for atopic dermatitis: a promising new therapy, PMID: 33347600

Tralokinumab for moderate-to-severe atopic dermatitis: results from two 52-week, randomized, double-blind, multicentre, placebo-controlled phase III trials (ECZTRA 1 and ECZTRA 2), PMID: 33000465

Tralokinumab for moderate-to-severe UC: a randomised, double-blind, placebo-controlled, phase IIa study, PMID: 25304132

Tralokinumab for severe, uncontrolled asthma (STRATOS 1 and STRATOS 2): two randomised, double-blind, placebo-controlled, phase 3 clinical trials, PMID: 29792288

Tralokinumab for the Treatment of Atopic Dermatitis, PMID: 34155602

Tralokinumab for the treatment of severe, uncontrolled asthma: the ATMOSPHERE clinical development program, PMID: 29536781

Tralokinumab for uncontrolled asthma, PMID: 23268592

Tralokinumab in atopic dermatitis, PMID: 34390128

Tralokinumab pharmacokinetics and tolerability when administered by different subcutaneous injection methods and rates, PMID: 28590244

Tralokinumab plus topical corticosteroids for the treatment of moderate-to-severe atopic dermatitis: results from the double-blind, randomized, multicentre, placebo-controlled phase III ECZTRA 3 trial, PMID: 33000503

Tralokinumab unsuccessful for management of severe, uncontrolled asthma, PMID: 29793858

Tralokinumab: First Approval, PMID: 34406631

Treatment of atopic dermatitis with tralokinumab, an anti-IL-13 mAb, PMID: 29906525

Understanding the immune landscape in atopic dermatitis: The era of biologics and emerging therapeutic approaches, PMID: 30825336

What's New in Atopic Dermatitis, PMID: 30850043

Long-Term Use of Tralokinumab in Patients With Atopic Dermatitis: A Real-World Multicentric Case Series., PMID:40528669

Corneal Perforation Associated With Tralokinumab., PMID:40525846

Letter: Effectiveness and Safety of Tralokinumab for the Elderly with Atopic Dermatitis in a Real-World Setting-IL AD., PMID:40470535

Real‑World Experience of 1 Year of Tralokinumab Treatment in Adult Patients with Atopic Dermatitis: A Single-Center Retrospective Study., PMID:40459712

Real-World Effectiveness and Safety of Dupilumab, Tralokinumab, and Upadacitinib in Patients with Atopic Dermatitis: A 52-Week International, Multicenter Retrospective Cohort Study., PMID:40459711

Suppression of Il5 and Il13 Gene Expression by Synthetic siRNA Molecules Reduces Nasal Hyperreactivity and Inflammation in a Murine Model of Allergic Rhinitis., PMID:40451198

Real-World Clinical Experience of Tralokinumab in a Tertiary Centre: An Alternative for Patients with Conjunctivitis on Dupilumab?, PMID:40442566

Deciding Which Patients With Atopic Dermatitis to Prioritize for Biologics and Janus Kinase Inhibitors., PMID:40368249

Editor's Highlights-June 2025., PMID:40322884

European Guideline (EuroGuiDerm) on atopic eczema: Living update., PMID:40317496

A Case of Cutaneous Fungal Infection Following the Administration of Dupilumab., PMID:40291282

Correction to: Real-World Evidence of Tralokinumab Effectiveness and Safety: A Systematic Review and Meta-analysis., PMID:40272773

Drug survival of dupilumab, tralokinumab and upadacitinib in patients with atopic dermatitis., PMID:40264378

Real-World pharmacovigilance analysis of drug-related conjunctivitis using the FDA adverse event reporting system database., PMID:40251175

Incidence of upper respiratory tract infections with biological therapies in moderate to severe atopic dermatitis: a systematic review and meta-analysis., PMID:40241901

Long-Term Efficacy and Potential Predictors of Tralokinumab Dose Optimization in Elderly Patients: A Multicentre Study., PMID:40232593

[Chronic Pruritus: A Review of Its Pathophysiology and Current Treatments]., PMID:40214004

Infection risk in atopic dermatitis patients treated with biologics and JAK inhibitors: BioDay results., PMID:40176741

Effectiveness of Switching From Upadacitinib to Tralokinumab in Patients With Moderate-to-Severe Atopic Dermatitis: A Real-World Clinical Practice., PMID:40165566

A Case of Unexpected Successful Treatment of Alopecia Areata With Tralokinumab in a Patient With Atopic Dermatitis., PMID:40152261

Effectiveness of Tralokinumab Across Atopic Dermatitis Phenotypes., PMID:40142885

Real-world experience of switching from tralokinumab to lebrikizumab in atopic dermatitis., PMID:40130939

Long-Term Disease Control and Minimal Disease Activity of Head and Neck Atopic Dermatitis in Patients Treated with Tralokinumab up to 4 Years., PMID:40085349

Investigating Efficacy of Atopic Dermatitis Systemic Therapeutics After Discontinuation Part I: Biologics., PMID:40078859

Effectiveness and Safety of Tralokinumab in Atopic Dermatitis: 1-year Results From a Real-world Multicentre Study., PMID:40077977

Long-term Outcomes of New Systemic Agents in Atopic Dermatitis: Drug Survival Analyses and Treatment Patterns in Daily Practice., PMID:40059465

Real-World Evidence of Tralokinumab Effectiveness and Safety: A Systematic Review and Meta-analysis., PMID:40045152

Comparative Real-World Analysis of Baseline Demographic Characteristics and Comorbidities in Atopic Dermatitis Patients Initiating Biologics Versus JAK Inhibitors., PMID:40004820

Comparative efficacy and safety of dupilumab versus newly approved biologics and JAKi in pediatric atopic dermatitis: A systematic review and network meta-analysis., PMID:39992967

Executive summary: Japanese guidelines for atopic dermatitis (ADGL) 2024., PMID:39986987

Lebrikizumab vs Other Systemic Monotherapies for Moderate-to-Severe Atopic Dermatitis: Network Meta-analysis of Efficacy., PMID:39953372

Comparison chart: Interleukin (IL) receptor antagonists for atopic dermatitis., PMID:39946701

Nemolizumab (Nemluvio) for atopic dermatitis., PMID:39946696

Higher Baseline Lactate Dehydrogenase and History of Allergic Rhinitis as Predictive Factors of Conjunctivitis in Atopic Dermatitis Patients Treated with Tralokinumab., PMID:39937140

Effectiveness of Tralokinumab for Different Anatomical Sites and Clinical Signs in Atopic Dermatitis: A 36-Week Real-World Study., PMID:39932721

Drug survival of dupilumab, tralokinumab and upadacitinib in patients with atopic dermatitis: An international, real-world comparative study., PMID:39912554

Erythrodermic atopic dermatitis responding to tralokinumab after dupilumab failure., PMID:39912174

Predictive Factors for Poor Responders to Tralokinumab in Moderate-to-Severe Atopic Dermatitis: A Real-World Analysis., PMID:39907080

Effectiveness and Safety of Dupilumab and Tralokinumab for Treating Atopic Dermatitis and Pruritic Skin Disorders in Oncological Patients: A Narrative Review., PMID:39901963

Diagnosis of cutaneous T-cell lymphoma following exposure to biologic agents for atopic dermatitis: A retrospective cohort study from a single tertiary cancer center., PMID:39900188

Efficacy and Drug Survival of Tralokinumab in Severe Atopic Dermatitis: An 18-Month Multicenter Experience., PMID:39899459

Off-label use of tralokinumab in the treatment of bullous pemphigoid: a case series., PMID:39878153

Real-world experience of tralokinumab for atopic dermatitis: A 16-week multicenter retrospective study., PMID:39864749

Effectiveness of Tralokinumab in Different Phenotypes of Atopic Dermatitis: A Real-World Study., PMID:39862316

Upadacitinib and Dupilumab Demonstrate Superior Efficacy in the Treatment of Adolescent Atopic Dermatitis: A Network Meta-Analysis., PMID:39827864

Correction: Matching-Adjusted Indirect Comparison of the Efficacy at Week 32 of Tralokinumab and Dupilumab in the Treatment of Moderate-to-Severe Atopic Dermatitis., PMID:39821857

Biomarkers in Atopic Dermatitis: A Review of the Role of IL-13 and the Impact of Tralokinumab Treatment., PMID:39820896

Tralokinumab Treatment of Atopic Dermatitis Induces a Progressive Transcriptomic Response., PMID:39733934

Identification of Early and Late Responders to Anti-IL-13 Antibody Tralokinumab in Atopic Dermatitis: A Real-World Japanese Study., PMID:39729342

English version of clinical practice guidelines for the management of atopic dermatitis 2024., PMID:39707640

Datasheet

Document Download

Research Grade Tralokinumab.pdf

 

$ 328
Product specifications
100 μg 328 1 mg 1314

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Research Grade Tralokinumab [DHE07703]
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