Catalog No.
YHK60201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ile67-Ser293
Predicted molecular weight
27.44 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9Y337
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
KLK5, Stratum corneum tryptic enzyme, SCTE, Kallikrein-like protein 2, Kallikrein-5, KLK-L2
POSTN Silencing Ameliorates LL37-Induced Rosacea and Inhibits the JAK2/STAT3 and NF-κB Pathways., PMID:40387439
Blocking of IL-4/IL-13 Signalling With Dupilumab Results in Restoration of Serum and Cutaneous Abnormalities in Netherton Syndrome., PMID:40344324
The antiprotease Spink7 promotes inflammation resolution by modulating multiple proteases activities during wound healing., PMID:40147022
Causal role of immune cells in head and neck squamous cell carcinoma., PMID:40119021
Homology-based identification and structural analysis of Pangasius hypophthalmus Annexins and Serine proteases to search molecules for wound healing applications., PMID:39507818
Cell-free adipose tissue extracts as a novel treatment for rosacea by downregulating TRPV1., PMID:39294294
Liquid-liquid phase separation-related genes associated with prognosis, tumor microenvironment characteristics, and tumor cell features in bladder cancer., PMID:39269596
The host protease KLK5 primes and activates spike proteins to promote human betacoronavirus replication and lung inflammation., PMID:39163389
Sphingolipid-Enriched Porcine Placental Extract Promotes the Expression of Structural Genes and Desquamation Enzyme Genes in Cultured Human Keratinocytes., PMID:38945844
LEKTI domain 6 displays anti-inflammatory action in vitro and in a murine atopic dermatitis model., PMID:38849289
Bioinformatics analysis of human kallikrein 5 (KLK5) expression in metaplastic triple-negative breast cancer., PMID:38090381
Αnti-KLK5/KLK7 Antibody-based Strategies for the Treatment of Epidermal Diseases., PMID:37987118
Novel CSF biomarkers for diagnosis and integrated analysis of neuropsychiatric systemic lupus erythematosus: based on antibody profiling., PMID:37684700
MiR-107-3p Knockdown Alleviates Endothelial Injury in Sepsis via Kallikrein-Related Peptidase 5., PMID:37666089
Overcoming Soluble Target Interference in Measurement of Total Bispecific Therapeutic Antibody Concentrations., PMID:37594571
Minireview: functional roles of tissue kallikrein, kinins, and kallikrein-related peptidases in lung cancer., PMID:37405520
Mini-PBPK-Based Population Model and Covariate Analysis to Assess the Complex Pharmacokinetics and Pharmacodynamics of RO7449135, an Anti-KLK5/KLK7 Bispecific Antibody in Cynomolgus Monkeys., PMID:37353723
The peptide bond rupture mechanism in the serine proteases: an in silico study based on sequential scale models., PMID:36876585
FFA-Fetuin-A regulates DPP-IV expression in pancreatic beta cells through TLR4-NFkB pathway., PMID:36716646
New Data on the Features of Skin Barrier in Hidradenitis Suppurativa., PMID:36672635
Dual antibody inhibition of KLK5 and KLK7 for Netherton syndrome and atopic dermatitis., PMID:36516271
Mast cell stabilization: new mechanism underlying the therapeutic effect of intense pulsed light on rosacea., PMID:36329130
Betula alba Bark Extract and Empetrum nigrum Fruit Juice, a Natural Alternative to Niacinamide for Skin Barrier Benefits., PMID:36293365
Challenges in Noninvasive Skin Biomarker Measurements in Daily Practice: A Longitudinal Study on Skin Surface Protein Detection by the Transdermal Analysis Patch in Pediatric Psoriasis., PMID:36202075
Cellular Heterogeneity and Cooperativity in Glioma Persister Cells Under Temozolomide Treatment., PMID:35693929
Phage Display Selected Cyclic Peptide Inhibitors of Kallikrein-Related Peptidases 5 and 7 and Their In Vivo Delivery to the Skin., PMID:35653695
KLK5 is associated with the radioresistance, aggression, and progression of cervical cancer., PMID:35595569
Genome-wide association study identifies kallikrein 5 in type 2 inflammation-low asthma., PMID:35487308
Cocktails of KLK5 Protease Inhibitors and Anti-TNFα Therapeutics: an Effective Treatment for Netherton Syndrome., PMID:35040012
SPINK6 inhibits human airway serine proteases and restricts influenza virus activation., PMID:34826211
Host-Microbiota Interactions in the Esophagus During Homeostasis and Allergic Inflammation., PMID:34627858
Kallikrein-related peptidase 5 contributes to the remodeling and repair of bronchial epithelium., PMID:34582061
Protective effect of oligosaccharides isolated from Panax ginseng C. A. Meyer against UVB-induced skin barrier damage in BALB/c hairless mice and human keratinocytes., PMID:34562563
Clinical significance of kallikrein 5 as a novel prognostic biomarker in gastric adenocarcinoma., PMID:34510543
Kallikreins emerge as new regulators of viral infections., PMID:34459952
STAT3 maintains skin barrier integrity by modulating SPINK5 and KLK5 expression in keratinocytes., PMID:34378233
A Novel Mechanism of Carvedilol Efficacy for Rosacea Treatment: Toll-Like Receptor 2 Inhibition in Macrophages., PMID:34322115
Search for Non-Protein Protease Inhibitors Constituted with an Indole and Acetylene Core., PMID:34201422
A novel theranostic activity-based probe targeting kallikrein 7 for the diagnosis and treatment of skin diseases., PMID:34105530
Skin Surface Protein Detection by Transdermal Analysis Patches in Pediatric Psoriasis., PMID:34015784
Tissue factor pathway inhibitor 2 is a potent kallikrein-related protease 12 inhibitor., PMID:33977679
Salivary KLK5 and uPA are potential biomarkers for malignant transformation of OLK and OLP., PMID:33896830
A Potent and Selective Kallikrein-5 Inhibitor Delivers High Pharmacological Activity in Skin from Patients with Netherton Syndrome., PMID:33744298
Derma-Hc, a New Developed Herbal Formula, Ameliorates Cutaneous Lichenification in Atopic Dermatitis., PMID:33652999
Identification of MFGE8 and KLK5/7 as mediators of breast tumorigenesis and resistance to COX-2 inhibition., PMID:33588911
Relative expression of KLK5 to LEKTI is associated with aggressiveness of oral squamous cell carcinoma., PMID:33260070
Coptis chinensis Franch Directly Inhibits Proteolytic Activation of Kallikrein 5 and Cathelicidin Associated with Rosacea in Epidermal Keratinocytes., PMID:33256158
Long noncoding RNA HEIH depletion depresses esophageal carcinoma cell progression by upregulating microRNA-185 and downregulating KLK5., PMID:33223519
Compound K improves skin barrier function by increasing SPINK5 expression., PMID:33192123
Prognostic value of kallikrein-related peptidase 7 (KLK7) mRNA expression in advanced high-grade serous ovarian cancer., PMID:33087135
For research use only. Not for human or drug use.
