Catalog No.
EHG02801
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Met21-Glu123
Predicted molecular weight
14.39 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q04771
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Activin receptor type-1, 2.7.11.30, Activin receptor type I, ACTR-I, Activin receptor-like kinase 2, ALK-2, Serine/threonine-protein kinase receptor R1, SKR1, TGF-B superfamily receptor type I, TSR-I, ACVR1, ACVRLK2
Combined rapamycin and mesenchymal stem/stromal cells derived from induced pluripotent stem cells-mediated delivery of ACVR2B-Fc fusion protein reduces heterotopic ossification in a mouse model of fibrodysplasia ossificans progressiva., PMID:40416557
Momelotinib - a tale of trials, tribulations, transfusion independence, and triumph., PMID:40405506
Advancements in mechanisms and drug treatments for fibrodysplasia ossificans progressiva., PMID:40274382
ACVR1 drives neuropathic pain by regulating NLRP3-Induced neuronal pyroptosis through the p38 and Smad1/5/8 pathways., PMID:40250754
Fibrodysplasia ossificans progressiva: genetic and clinical characterization in a cohort of Polish patients and review of potential therapies., PMID:40220125
The transcription factor LHX2 mediates and enhances oncogenic BMP signaling in medulloblastoma., PMID:40148468
Expression and distribution of activin-follistatin-inhibin axis in the urinary bladder., PMID:40144023
Interplay between ALK2R206H mutant receptor and autophagy signaling regulates receptor stability and its chondrogenic functions., PMID:40121219
Targeted Therapies in Myelofibrosis: Present Landscape, Ongoing Studies, and Future Perspectives., PMID:40062529
Emerging Pathogenetic Mechanisms and New Drugs for Anemia in Myelofibrosis and Myelodysplastic Syndromes., PMID:40056069
Establishment of xenografts and methods to evaluate tumor burden for the three most frequent subclasses of pediatric-type diffuse high grade gliomas., PMID:39961939
CD9-enriched extracellular vesicles from chemically reprogrammed basal progenitors of salivary glands mitigate salivary gland fibrosis., PMID:39925710
Helicobacter pylori infection induces DNA double-strand breaks through the ACVR1/IRF3/POLD1 signaling axis to drive gastric tumorigenesis., PMID:39924917
Discoidin domain receptor 2 is an important modulator of BMP signaling during heterotopic bone formation., PMID:39746922
Generalized Epileptic Seizures in Fibrodysplasia Ossificans Progressiva Harboring a Recurrent Heterozygous Variant of the ACVR1 Gene (R206H)., PMID:39719967
ACVR1 mediates renal tubular EMT in kidney fibrosis via AKT activation., PMID:39586521
Bone phenotyping of murine hemochromatosis models with deficiencies of Hjv, Alk2, or Alk3: The influence of sex and the bone compartment., PMID:39545682
Discovery of highly potent and ALK2/ALK1 selective kinase inhibitors using DNA-encoded chemistry technology., PMID:39541346
Pacritinib Response Is Associated With Overall Survival in Myelofibrosis: PERSIST-2 Landmark Analysis of Survival., PMID:39400386
BMP2 and BMP7 cooperate with H3.3K27M to promote quiescence and invasiveness in pediatric diffuse midline gliomas., PMID:39373720
Challenges in the diagnosis of fibrodysplasia ossificans progressiva with the ACVR1 mutation (c.774G > C, p.R258S): a case report and review of literature., PMID:39350127
Fibrodysplasia ossificans progressiva emerges from obscurity., PMID:39299836
Unlocking the Door for Precision Medicine in Rare Conditions: Structural and Functional Consequences of Missense ACVR1 Variants., PMID:39288033
[A case of progressive ossifying myositis caused by ACVR1 gene mutation]., PMID:39267512
Live-Cell Invasive Phenotyping Uncovers ALK2 as a Therapeutic Target in LKB1-Mutant Lung Cancer., PMID:39207369
Molecular Developmental Biology of Fibrodysplasia Ossificans Progressiva: Measuring the Giant by Its Toe., PMID:39199396
Momelotinib: Mechanism of action, clinical, and translational science., PMID:39189872
Unraveling druggable cancer-driving proteins and targeted drugs using artificial intelligence and multi-omics analyses., PMID:39169044
Primary cilia mediate skeletogenic BMP and Hedgehog signaling in heterotopic ossification., PMID:39047114
Consistency of Spleen and Symptom Reduction Regardless of Cytopenia in Patients With Myelofibrosis Treated With Pacritinib., PMID:39034203
ACVR1/ALK2-p21 signaling axis modulates proliferation of the venous endothelium in the retinal vasculature., PMID:38955953
Investigation of single nucleotide polymorphisms in differentially expressed genes and proteins reveals the genetic basis of skeletal muscle growth differences between Tibetan and Large White pigs., PMID:38938033
Whole-genome SNP allele frequency differences between Tibetan and Large white pigs reveal genes associated with skeletal muscle growth., PMID:38862895
Prediction of the Signaling Pathway in Polycystic Ovary Syndrome Using an Integrated Bioinformatics Approach., PMID:38810612
SEMA3G regulates BMP9 inhibition of VEGF-mediated migration and network formation in pulmonary endothelial cells., PMID:38795838
Gprc5a is a novel parathyroid hormone-inducible gene and negatively regulates osteoblast proliferation and differentiation., PMID:38769895
Specific exercise patterns generate an epigenetic molecular memory window that drives long-term memory formation and identifies ACVR1C as a bidirectional regulator of memory in mice., PMID:38714691
BMP7 promotes cardiomyocyte regeneration in zebrafish and adult mice., PMID:38678558
Cell Senescence in Heterotopic Ossification., PMID:38672501
Inhibition of YAP/TAZ pathway contributes to the cytotoxicity of silibinin in MCF-7 and MDA-MB-231 human breast cancer cells., PMID:38643945
BRCC3 Regulation of ALK2 in Vascular Smooth Muscle Cells: Implication in Pulmonary Hypertension., PMID:38557054
Hedgehog Signaling Controls Chondrogenesis and Ectopic Bone Formation via the Yap-Ihh Axis., PMID:38540766
iMSC-mediated delivery of ACVR2B-Fc fusion protein reduces heterotopic ossification in a mouse model of fibrodysplasia ossificans progressiva., PMID:38500216
Silibinin is a suppressor of the metastasis-promoting transcription factor ID3., PMID:38484626
The prognostic value and potential immunotherapeutic efficacy of ACVR1 in treating gastric cancer., PMID:38482233
Matrix metalloproteinase-9 deficiency confers resilience in fibrodysplasia ossificans progressiva in a man and mice., PMID:38477818
A BMP-controlled metabolic/epigenetic signaling cascade directs midfacial morphogenesis., PMID:38466355
Role of the NF-kB signalling pathway in heterotopic ossification: biological and therapeutic significance., PMID:38439078
Sex as a Critical Variable in Basic and Pre-Clinical Studies of Fibrodysplasia Ossificans Progressiva., PMID:38397414
For research use only. Not for human or drug use.
