Anti-Optineurin Antibody (6A7.1)

Catalog No.

RHK35701

Species reactivity

Human

Host species

Mouse

Isotype

IgG2a

Clonality

Monoclonal

Target

NRP, TFIIIA-IntP, Huntingtin-interacting protein 7, HIP-7, Huntingtin yeast partner L, Transcription factor IIIA-interacting protein, NEMO-related protein, E3-14.7K-interacting protein, GLC1E, HIP7, HYPL, FIP-2, Huntingtin-interacting protein L, Optic neuropathy-inducing protein, OPTN, Optineurin, FIP2

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q96CV9

Applications

IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

6A7.1

Cleavage of the selective autophagy receptor NBR1 by the PDCoV main protease NSP5 impairs autophagic degradation of the viral envelope protein., PMID:40047225

Deciphering melanophagy: role of the PTK2-ITCH-MLANA-OPTN cascade on melanophagy in melanocytes., PMID:39477686

Cleavage of SQSTM1/p62 by the Zika virus protease NS2B3 prevents autophagic degradation of viral NS3 and NS5 proteins., PMID:39128850

Compartmentalized mitochondrial ferroptosis converges with optineurin-mediated mitophagy to impact airway epithelial cell phenotypes and asthma outcomes., PMID:38987265

CCDC50 mediates the clearance of protein aggregates to prevent cellular proteotoxicity., PMID:38869076

Porcine reproductive and respiratory syndrome virus degrades DDX10 via SQSTM1/p62-dependent selective autophagy to antagonize its antiviral activity., PMID:36779599

Neutralizing peripheral circulating IL1β slows the progression of ALS in a lentivirus-infected OPTNE478G mouse model., PMID:36575589

TRAF6 autophagic degradation by avibirnavirus VP3 inhibits antiviral innate immunity via blocking NFKB/NF-κB activation., PMID:35266845

MEK inhibition overcomes chemoimmunotherapy resistance by inducing CXCL10 in cancer cells., PMID:35051357

The small molecule inhibitor PR-619 protects retinal ganglion cells against glutamate excitotoxicity., PMID:32991521

Emerging views of mitophagy in immunity and autoimmune diseases., PMID:30951392

Parkin overexpression protects retinal ganglion cells against glutamate excitotoxicity., PMID:28761318

Inducible turnover of optineurin regulates T cell activation., PMID:28192730

A Glaucoma-Associated Variant of Optineurin, M98K, Activates Tbk1 to Enhance Autophagosome Formation and Retinal Cell Death Dependent on Ser177 Phosphorylation of Optineurin., PMID:26376340

Mutations in the ubiquitin-binding domain of OPTN/optineurin interfere with autophagy-mediated degradation of misfolded proteins by a dominant-negative mechanism., PMID:25484089

E50K-OPTN-induced retinal cell death involves the Rab GTPase-activating protein, TBC1D17 mediated block in autophagy., PMID:24752605

Optineurin insufficiency impairs IRF3 but not NF-κB activation in immune cells., PMID:24244017

Interaction between optineurin and the bZIP transcription factor NRL., PMID:23956131

Co-aggregation of RNA binding proteins in ALS spinal motor neurons: evidence of a common pathogenic mechanism., PMID:22941224

Nuclear factor κ B expression in patients with sporadic amyotrophic lateral sclerosis and hereditary amyotrophic lateral sclerosis with optineurin mutations., PMID:22762947

Oligoclonal bands in the cerebrospinal fluid of amyotrophic lateral sclerosis patients with disease-associated mutations., PMID:22752089

[Identification of a new causative gene of amyotrophic lateral sclerosis; optineurin]., PMID:22260971

Depletion of optineurin in RGC-5 cells derived from retinal neurons causes apoptosis and reduces the secretion of neurotrophins., PMID:21896272

Clinicopathologic study on an ALS family with a heterozygous E478G optineurin mutation., PMID:21644038

Optineurin inclusions occur in a minority of TDP-43 positive ALS and FTLD-TDP cases and are rarely observed in other neurodegenerative disorders., PMID:21360076

Complex genetic mechanisms in glaucoma: an overview., PMID:21150032

Myosin VI and its binding partner optineurin are involved in secretory vesicle fusion at the plasma membrane., PMID:21148290

The case for autoimmunity in glaucoma., PMID:20801114

Mutations of optineurin in amyotrophic lateral sclerosis., PMID:20428114

Optineurin negatively regulates the induction of IFNbeta in response to RNA virus infection., PMID:20174559

Embryonic expression of the optineurin (glaucoma) gene in different stages of mouse development., PMID:17893645

A glaucoma-associated mutant of optineurin selectively induces death of retinal ganglion cells which is inhibited by antioxidants., PMID:17389490

Optineurin increases cell survival and translocates to the nucleus in a Rab8-dependent manner upon an apoptotic stimulus., PMID:16569640

Molecular cloning and expression profiling of optineurin in the rhesus monkey., PMID:15980228

Effects of prostaglandin analogues on human ciliary muscle and trabecular meshwork cells., PMID:12714628

Identification of a transcription factor IIIA-interacting protein., PMID:10756201

Document Download

Anti-Optineurin Antibody (6A7.1).pdf