Catalog No.
RHN17303
Host species
Mouse
Isotype
IgG2a, kappa
Clonality
Monoclonal
Target
PROSAP2, PSAP2, SHANK3, SH3 and multiple ankyrin repeat domains protein 3, Proline-rich synapse-associated protein 2, ProSAP2, KIAA1650, Shank3
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Applications
IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
N69/46
SHANK3 Antibody Validation: Differential Performance in Western Blotting, Immunocyto- and Immunohistochemistry., PMID:35734418
Lateralized Decrease of Parvalbumin+ Cells in the Somatosensory Cortex of ASD Models Is Correlated with Unilateral Tactile Hypersensitivity., PMID:34347040
CaMKII Phosphorylation Regulates Synaptic Enrichment of Shank3., PMID:33568460
Targeting of δ-catenin to postsynaptic sites through interaction with the Shank3 N-terminus., PMID:33115499
Subacute Neuropsychiatric Syndrome in Girls With SHANK3 Mutations Responds to Immunomodulation., PMID:32015180
Amyloid Beta Oligomers Target to Extracellular and Intracellular Neuronal Synaptic Proteins in Alzheimer's Disease., PMID:31736856
Unexpected Compensatory Increase in Shank3 Transcripts in Shank3 Knock-Out Mice Having Partial Deletions of Exons., PMID:31607862
Multiplexed and high-throughput neuronal fluorescence imaging with diffusible probes., PMID:31558769
Molecular hypotheses to explain the shared pathways and underlying pathobiological causes in catatonia and in catatonic presentations in neuropsychiatric disorders., PMID:29523295
Reduction in parvalbumin expression not loss of the parvalbumin-expressing GABA interneuron subpopulation in genetic parvalbumin and shank mouse models of autism., PMID:26819149
A patient with the classic features of Phelan-McDermid syndrome and a high immunoglobulin E level caused by a cryptic interstitial 0.72-Mb deletion in the 22q13.2 region., PMID:24375995
Loss of predominant Shank3 isoforms results in hippocampus-dependent impairments in behavior and synaptic transmission., PMID:24259569
Proline-rich synapse-associated protein-1 and 2 (ProSAP1/Shank2 and ProSAP2/Shank3)-scaffolding proteins are also present in postsynaptic specializations of the peripheral nervous system., PMID:20800661
Mutations in the gene encoding CADM1 are associated with autism spectrum disorder., PMID:18957284
Expression of postsynaptic density proteins of the ProSAP/Shank family in the thymus., PMID:16758162
Direct interaction of post-synaptic density-95/Dlg/ZO-1 domain-containing synaptic molecule Shank3 with GluR1 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor., PMID:16606358
Shank expression is sufficient to induce functional dendritic spine synapses in aspiny neurons., PMID:15814786
Synaptic contacts between identified neurons visualized in the confocal laser scanning microscope. Neuroanatomical tracing combined with immunofluorescence detection of post-synaptic density proteins and target neuron-markers., PMID:12948556
Characterization of the Shank family of synaptic proteins. Multiple genes, alternative splicing, and differential expression in brain and development., PMID:10506216
For research use only. Not for human or drug use.
