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Anti-mGluR1/5 (Group I) glutamate receptor Antibody (N75/3)

Catalog #:   RHG46101 Specific References (50) DATASHEET
Host species: Mouse
Isotype: IgG2a, kappa
Applications: IHC, WB
Overview

Catalog No.

RHG46101

Host species

Mouse

Isotype

IgG2a, kappa

Clonality

Monoclonal

Target

MGLUR1, GRM1, mGluR1, GPRC1A, Metabotropic glutamate receptor 1

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Applications

IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

N75/3

Data Image
References

Preferential Localization of STIM1 to dendritic subsurface ER structures in Mouse Purkinje Cells., PMID:40086872

Gluten Ataxia and mGluR1 Autoimmune Encephalitis Presenting as Acute Cerebellar Ataxia: A Case Report., PMID:39012773

Detection of GRM1 gene rearrangements in chondromyxoid fibroma: a comparison of fluorescence in-situ hybridisation, RNA sequencing and immunohistochemical analysis., PMID:38890779

Neuronal antibodies in nonparaneoplastic autoimmune cerebellar ataxias., PMID:38483149

Cerebellar encephalitis associated with anti-mGluR1 antibodies: a case report and comprehensive literature review., PMID:38410193

Anti-mGluR1 encephalitis: Case illustration and systematic review., PMID:37139064

Cerebellar ataxia with anti-mGluR1 auto-antibody in a pediatric patient: A case report., PMID:37119682

Favorable Outcome with Intravenous Immunoglobulin Therapy in Late-Onset Anti-mGluR1 Encephalitis: A Case Report and Literature Review., PMID:36654530

Teaching Video NeuroImage: Subacute Cerebellar Ataxia in an Adolescent With Antibodies Against Metabotropic Glutamate Receptor Type 1., PMID:36240082

Autoimmune Encephalitis With mGluR1 Antibodies Presenting With Epilepsy, but Without Cerebellar Signs: A Case Report., PMID:35450924

The Clinical Concept of LTDpathy: Is Dysregulated LTD Responsible for Prodromal Cerebellar Symptoms?, PMID:35326260

Advances in the Pathogenesis of Auto-antibody-Induced Cerebellar Synaptopathies., PMID:35064896

Cerebellar long-term depression and auto-immune target of auto-antibodies: the concept of LTDpathies., PMID:35006439

Structural insights into the activation initiation of full-length mGlu1., PMID:33278019

Clinical features, prognostic factors, and antibody effects in anti-mGluR1 encephalitis., PMID:32928978

Antibodies against metabotropic glutamate receptor type 1 in a toddler with acute cerebellitis., PMID:32861169

Neuro-Ophthalmic Features of Autoimmune Encephalitides., PMID:32804457

Fundamental Mechanisms of Autoantibody-Induced Impairments on Ion Channels and Synapses in Immune-Mediated Cerebellar Ataxias., PMID:32668612

The involvement of TRP channels in memory formation and task retrieval in a passive avoidance task in one-day old chicks., PMID:32147584

Autoimmune Vestibulocerebellar Syndromes., PMID:31958862

Nonhomologous end-joining repair is likely involved in the repair of double-stranded DNA breaks induced by riluzole in melanoma cells., PMID:31855905

Paraneoplastic cerebellar ataxia and antibodies to metabotropic glutamate receptor 2., PMID:31826987

Synaptic localization of C9orf72 regulates post-synaptic glutamate receptor 1 levels., PMID:31651360

Localization of group II and III metabotropic glutamate receptors at pre- and postsynaptic sites of inner hair cell ribbon synapses., PMID:31585509

Autoimmune encephalitis associated with antibodies against the metabotropic glutamate receptor type 1: case report and review of the literature., PMID:31205493

Reversible myoclonus-ataxia encephalitis related to anti-mGLUR1 autoantibodies., PMID:30759326

Glutamate Receptor Antibodies in Autoimmune Central Nervous System Disease: Basic Mechanisms, Clinical Features, and Antibody Detection., PMID:30707437

Nonparaneoplastic autoimmune cerebellar ataxias., PMID:30694927

Updates in the Diagnosis and Treatment of Paraneoplastic Neurologic Syndromes., PMID:30415318

Long-term clinical follow-up of a patient with non-paraneoplastic cerebellar ataxia associated with anti-mGluR1 autoantibodies., PMID:29685291

Video NeuroImages: Head titubation in anti-mGluR1 autoantibody-associated cerebellitis., PMID:29661893

Inhibition of group-I metabotropic glutamate receptors protects against prion toxicity., PMID:29176838

Experience with newer central nervous system autoantibodies., PMID:28726484

Anti-neuronal anti-bodies in patients with early psychosis., PMID:28461116

CNS syndromes associated with antibodies against metabotropic receptors., PMID:28306571

Group 1 metabotropic glutamate receptors 1 and 5 form a protein complex in mouse hippocampus and cortex., PMID:27392515

Anti-NMDAR encephalitis and other glutamate and GABA receptor antibody encephalopathies., PMID:27112679

Neuronal central nervous system syndromes probably mediated by autoantibodies., PMID:26918657

Metabotropic glutamate receptor type 1 autoimmunity: Clinical features and treatment outcomes., PMID:26888994

Screening for MOG-IgG and 27 other anti-glial and anti-neuronal autoantibodies in 'pattern II multiple sclerosis' and brain biopsy findings in a MOG-IgG-positive case., PMID:26869529

Brain penetration, target engagement, and disposition of the blood-brain barrier-crossing bispecific antibody antagonist of metabotropic glutamate receptor type 1., PMID:26839377

'Medusa head ataxia': the expanding spectrum of Purkinje cell antibodies in autoimmune cerebellar ataxia. Part 3: Anti-Yo/CDR2, anti-Nb/AP3B2, PCA-2, anti-Tr/DNER, other antibodies, diagnostic pitfalls, summary and outlook., PMID:26377319

'Medusa head ataxia': the expanding spectrum of Purkinje cell antibodies in autoimmune cerebellar ataxia. Part 2: Anti-PKC-gamma, anti-GluR-delta2, anti-Ca/ARHGAP26 and anti-VGCC., PMID:26377184

'Medusa-head ataxia': the expanding spectrum of Purkinje cell antibodies in autoimmune cerebellar ataxia. Part 1: Anti-mGluR1, anti-Homer-3, anti-Sj/ITPR1 and anti-CARP VIII., PMID:26377085

Glutamate receptor antibodies in neurological diseases: anti-AMPA-GluR3 antibodies, anti-NMDA-NR1 antibodies, anti-NMDA-NR2A/B antibodies, anti-mGluR1 antibodies or anti-mGluR5 antibodies are present in subpopulations of patients with either: epilepsy, encephalitis, cerebellar ataxia, systemic lupus erythematosus (SLE) and neuropsychiatric SLE, Sjogren's syndrome, schizophrenia, mania or stroke. These autoimmune anti-glutamate receptor antibodies can bind neurons in few brain regions, activate glutamate receptors, decrease glutamate receptor's expression, impair glutamate-induced signaling and function, activate blood brain barrier endothelial cells, kill neurons, damage the brain, induce behavioral/psychiatric/cognitive abnormalities and ataxia in animal models, and can be removed or silenced in some patients by immunotherapy., PMID:25081016

Tg(Grm1) transgenic mice: a murine model that mimics spontaneous uveal melanoma in humans?, PMID:25051141

Expression of astrocyte-related receptors in cortical dysplasia with intractable epilepsy., PMID:25003238

Aromatase and estrogen receptor beta expression in the rat olfactory bulb: Neuroestrogen action in the first relay station of the olfactory pathway?, PMID:24718039

The synaptic targeting of mGluR1 by its carboxyl-terminal domain is crucial for cerebellar function., PMID:24523559

Seronegative paraneoplastic cerebellar degeneration: the PNS Euronetwork experience., PMID:24471811

Datasheet
$ 328
Product specifications
100 μg 328 1 mg 1640

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Anti-mGluR1/5 (Group I) glutamate receptor Antibody (N75/3) [RHG46101]
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