Catalog No.
EHJ92201
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Met1-Asn160
Predicted molecular weight
44.95 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9Y6Y9
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Ly-96, ESOP-1, MD2, Lymphocyte antigen 96, Protein MD-2, LY96, ESOP1
Higher order receptor clustering due to the IgG3 subclass is necessary for TLR4 signaling and tolerance induction by novel human anti-TLR4 antibodies., PMID:40464120
Molecular profiling reveals the malignant potential in solid pseudopapillary neoplasms of the pancreas., PMID:40381684
Structural insight into TLR4/MD-2 activation by synthetic LPS mimetics with distinct binding modes., PMID:40325026
Cycloastragenol reduces inflammation in CLP-induced septic MICE by suppressing TLR4 signaling pathways., PMID:40319834
The potential crosstalk genes and molecular mechanisms between systemic lupus erythematosus and periodontitis., PMID:40309038
Amylase trypsin inhibitors activation of toll-like receptor 4 revisited: The dominance of lipopolysaccharides contamination., PMID:40288707
Discovery of potent MD2 inhibitors by hierarchical virtual screening strategy and bioactivity evaluation., PMID:40216147
Preclinical development of the TLR4 antagonist FP12 as a drug lead targeting the HMGB1/MD-2/TLR4 axis in lethal influenza infection., PMID:40033742
Serum Amyloid A1 Mediates Paclitaxel Resistance via MD2-Dependent Pathways in Triple-Negative Breast Cancer., PMID:40012323
Mechanism of Qingjie Fuzheng Granules in inhibiting colitis associated colorectal cancer by regulating TLR4 and IL-4R mediated macrophage polarization., PMID:39978444
Multifunctional Injectable Bioadhesive with Toll-like Receptor 4 and Myeloid Differentiation Factor 2 Antagonistic Anti-inflammatory Potential for Periodontal Regeneration., PMID:39951685
The NLRP3 activation-related signature predicts the diagnosis and indicates immune characteristics in endometriosis., PMID:39904070
The protective effect of amitriptyline on experimental colitis through inhibiting TLR-4/MD-2 signaling pathway., PMID:39892990
TLR3 as an emerging molecule facilitating pyroptosis in the context of rheumatoid arthritis: A study combined bioinformatics and experimental validation., PMID:39884182
The natural product-derived JM-9 alleviates high-fat diet-induced fatty liver in mice by targeting MD2., PMID:39827672
Extracellular peroxiredoxin 6 released from alveolar epithelial cells as a DAMP drives macrophage activation and inflammatory exacerbation in acute lung injury., PMID:39823791
Study on Immune-Related Genes and Clinical Validation of Acute Myocardial Infarction Based on Bioinformatics., PMID:39820825
Baicalin ameliorates neuroinflammation by targeting TLR4/MD2 complex on microglia via PI3K/AKT/NF-κB signaling pathway., PMID:39798687
Beyond the Toll-Like Receptor 4. Structure-Dependent Lipopolysaccharide Recognition Systems: How far are we?, PMID:39752323
Isoliquiritigenin Exhibits Anti-Inflammatory Responses in Acute Lung Injury by Covalently Binding to the Myeloid Differentiation Protein-2 Domain., PMID:39697044
Structural Diversity and Mutational Challenges of Toll-Like Receptor 4 Antagonists as Inflammatory Pathway Blocker., PMID:39690962
Novel Inhibitory Actions of Neuroactive Steroid [3α,5α]-3-Hydroxypregnan-20-One on Toll-like Receptor 4-Dependent Neuroimmune Signaling., PMID:39595617
The shared biomarkers and immune landscape in psoriatic arthritis and rheumatoid arthritis: Findings based on bioinformatics, machine learning and single-cell analysis., PMID:39509434
FOXA2 inhibits the TLR4/NF-κB signaling pathway and alleviates inflammatory activation of macrophages in rheumatoid arthritis by repressing LY96 transcription., PMID:39486110
Peptide TaY Attenuates Inflammatory Responses by Interacting with Myeloid Differentiation 2 and Inhibiting NF-κB Signaling Pathway., PMID:39459211
Multiscale drug screening for cardiac fibrosis identifies MD2 as a therapeutic target., PMID:39413786
Three undescribed isosteroidal alkaloids from the bulbs of Fritillaria ussuriensis maxim: Anti-inflammatory activities, docking studies and molecular dynamic., PMID:39395696
Blocking Brain Myeloid Differentiation Factor 2-Toll-like Receptor 4 Signaling Improves Cognition by Diminishing Brain Pathologies and Preserving Adult Hippocampal Neurogenesis in Obese Rats., PMID:39373789
Ginsenoside Rh2 Alleviates LPS-Induced Inflammatory Responses by Binding to TLR4/MD-2 and Blocking TLR4 Dimerization., PMID:39273493
Myeloid differentiation protein 2 regulates the innate immunity and the disease resistant against Vibrio alginolyticus in Scylla paramamosain., PMID:39260529
Cyclic-di-GMP induces inflammation and acute lung injury through direct binding to MD2., PMID:39166890
Association of M2 macrophages with EMT in glioma identified through combination of multi-omics and machine learning., PMID:39145022
Nicotine Enantioselectively Targets Myeloid Differentiation Protein 2 and Inhibits the Toll-like Receptor 4 Signaling., PMID:38973303
Identification of core genes shared by ischemic stroke and myocardial infarction using an integrated approach., PMID:38968466
Screening of Poria cocos polysaccharide with immunomodulatory activity and its activation effects on TLR4/MD2/NF-κB pathway., PMID:38942665
Dissecting the Role of the Hydroxyl Moiety at C14 in (+)-Opioid-Based TLR4 Antagonists via Wet-Lab Experiments and Molecular Dynamics Simulations., PMID:38921627
Overexpression of MD1 ameliorates pathological myocardial remodeling in diabetic cardiomyopathy by TLR4/STAT3 signaling pathway., PMID:38878954
In Silico Analyses Indicate a Lower Potency for Dimerization of TLR4/MD-2 as the Reason for the Lower Pathogenicity of Omicron Compared to Wild-Type Virus and Earlier SARS-CoV-2 Variants., PMID:38791489
Oxypeucedanin hydrate alleviates rheumatoid arthritis by inhibiting the TLR4-MD2/NF-κB/MAPK signaling axis., PMID:38734936
Dried tangerine peel polysaccharide (DTPP) alleviates hepatic steatosis by suppressing TLR4/MD-2-mediated inflammation and endoplasmic reticulum stress., PMID:38640721
Lymphocyte antigen 96: A new potential biomarker and immune target in Parkinson's disease., PMID:38614225
Structure-Based Design and Synthesis of Lipid A Derivatives to Modulate Cytokine Responses., PMID:38587187
Gastrodin Attenuates Colitis and Prevents Tumorigenesis in Mice by Interrupting TLR4/MD2/NF-κB Signaling Transduction., PMID:38584532
Dehydrocostus lactone alleviates irinotecan-induced intestinal mucositis by blocking TLR4/MD2 complex formation., PMID:38518649
Immunogenic cell death related mRNAs associated signature to predict immunotherapeutic response in osteosarcoma., PMID:38515694
The potential crosstalk genes and molecular mechanisms between glioblastoma and periodontitis., PMID:38472293
Dissecting the chiral recognition of TLR4/MD2 with Neoseptin-3 enantiomers by molecular dynamics simulations., PMID:38426248
Exploration of potential shared gene signatures between periodontitis and multiple sclerosis., PMID:38218802
Myeloid differentiation factor-2/LY96, a potential predictive biomarker of metastasis and poor outcomes in prostate cancer: clinical implications as a potential therapeutic target., PMID:38135694
Immunological characteristics of immunogenic cell death genes and malignant progression driving roles of TLR4 in anaplastic thyroid carcinoma., PMID:37990304
For research use only. Not for human or drug use.
