Catalog No.
EHD49201
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Ala2-Ala687
Predicted molecular weight
80.18 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P21980
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Protein-glutamine gamma-glutamyltransferase 2, 2.3.2.13, Erythrocyte transglutaminase, Heart G alpha(h), hhG alpha(h), Isopeptidase TGM2, 3.4.-.-, Protein G alpha(h), G(h), Protein-glutamine deamidase TGM2, 3.5.1.44, Protein-glutamine dopaminyltransferase TGM2, 2.3.1.-, Protein-glutamine histaminyltransferase TGM2, 2.3.1.-, Protein-glutamine noradrenalinyltransferase TGM2, 2.3.1.-, Protein-glutamine serotonyltransferase TGM2, 2.3.1.-, Tissue transglutaminase, tTG, tTgase, Transglutaminase C, TG(C), TGC, TGase C, Transglutaminase H, TGase H, Transglutaminase II, TGase II, Transglutaminase-2, TG2, TGase-2, hTG2, TGM2
Transglutaminase 2-mediated glutamine deamidation enhances p21 stability during senescence., PMID:40498452
Proteomic Analysis of the Extracellular Matrix in the Porcine Adrenal Cortex., PMID:40493856
Transglutaminase 2-expressing macrophages modulate adipose tissue inflammation., PMID:40467990
Novel therapeutic targets for metabolism-related diseases: proteomic Mendelian randomization and colocalization analyses., PMID:40453312
Pancreatic cancer cell-intrinsic transglutaminase-2 promotes T cell suppression through microtubule-dependent secretion of immunosuppressive cytokines., PMID:40447317
Transglutaminase 2 nuclear localization enhances glioblastoma radiation resistance., PMID:40445445
Canonical and Truncated Transglutaminase-2 Drive TGF-β1 Autocrine Loop to Induce Fibrosis in Graves' Orbitopathy., PMID:40358584
Macrophage response to fibrin structure mediated by Tgm2-dependent mitochondrial mechanosensing., PMID:40331213
Overexpression of Tgm2 in Chinese Hamster Ovary Cells Enhances Recombinant Monoclonal Antibody Expression and Promotes Cell Proliferation through Reduction of Apoptosis., PMID:40327404
Reprograming Model of Human Monocyte-derived Macrophages for In-vitro Assays., PMID:40323795
Role of oxysterol 4β-hydroxycholesterol and liver X receptor alleles in pre-eclampsia., PMID:40298034
Transglutaminase 2 promotes breast cancer cell autophagy by targeting p53/ mTOR axis., PMID:40216264
Sodium-Glucose Cotransporter 2 (SGLT2) as a Potential Biomarker and Target in Papillary Renal Cell Carcinoma., PMID:40020263
Glycated α-Synuclein Renders Glial Cell Activation and Induces Degeneration of Dopaminergic Neurons: A Potential Implication for the Development of Parkinson's Disease., PMID:39982250
5-HT orchestrates histone serotonylation and citrullination to drive neutrophil extracellular traps and liver metastasis., PMID:39903533
Transglutaminase 2 reduces the polyspermy of porcine oocytes by promoting the hardening of zona pellucida., PMID:39892069
Pancreatic cancer cell-intrinsic transglutaminase-2 promotes T cell suppression through microtubule-dependent secretion of immunosuppressive cytokines., PMID:39824529
Critical Role for Transglutaminase 2 in Scleroderma Skin Fibrosis and in the Development of Dermal Sclerosis in a Mouse Model of Scleroderma., PMID:39800950
The Search for a Universal Treatment for Defined and Mixed Pathology Neurodegenerative Diseases., PMID:39769187
Tgm2-Catalyzed Covalent Cross-Linking of IκBα Drives NF-κB Nuclear Translocation to Promote SASP in Senescent Microglia., PMID:39749582
Genomic and Transcriptomic Analysis of Ameloblastoma Reveals Distinct Molecularly Aggressive Phenotypes., PMID:39675431
THBS1 mediates hypoxia driven EndMT in pulmonary hypertension., PMID:39635464
RSL3 sensitizes glioma cells to ionizing radiation by suppressing TGM2-dependent DNA damage repair and epithelial-mesenchymal transition., PMID:39580966
Role of transglutaminase 2 in promoting biglycan synthesis in idiopathic gingival fibromatosis., PMID:39574071
Enhancing substrate specificity of microbial transglutaminase for precise nanobody labeling., PMID:39552758
Expression of transglutaminase-2 (TGM2) in the prognosis of female invasive breast cancer., PMID:39516660
TGM2-Mediated Autophagy Contributes to the Radio-Resistance of Non-Small Cell Lung Cancer Stem-like Cells., PMID:39457544
Sohlh2 Promotes the Progression of Hepatocellular Carcinoma via TGM2-Mediated Autophagy., PMID:39436118
Tumor-associated macrophages induce epithelial-mesenchymal transition and promote lung metastasis in breast cancer by activating the IL-6/STAT3/TGM2 axis., PMID:39426226
Tubuloside A alleviates postmyocardial infarction cardiac fibrosis by inhibiting TGM2: Involvement of inflammation and mitochondrial pathway apoptosis., PMID:39393274
Transglutaminase 2 promotes epithelial-to-mesenchymal transition by regulating the expression of matrix metalloproteinase 7 in colorectal cancer cells via the MEK/ERK signaling pathway., PMID:39389321
α9β1 integrin & its ligands as new potential biomarkers in FMF., PMID:39382510
TMT-Based Quantitative Proteomic Profiling of Human Esophageal Cancer Cells Reveals the Potential Mechanism and Potential Therapeutic Targets Associated With Radioresistance., PMID:39375892
Combined Inhibition of MNK Signaling and BET Proteins Reveals TGM2 as a Novel Vulnerability in Melanoma., PMID:39357785
A rigorous multi-laboratory study of known PDAC biomarkers identifies increased sensitivity and specificity over CA19-9 alone., PMID:39276915
Role of Serotonylation and SERT Posttranslational Modifications in Alzheimer's Disease Pathogenesis., PMID:39254383
A guide to selecting high-performing antibodies for Protein-glutamine gamma-glutamyltransferase 2 (TGM2) for use in western blot, immunoprecipitation and immunofluorescence., PMID:39220380
pH-Controlled Chemoselective Rapid Azo-Coupling Reaction (CRACR) Enables Global Profiling of Serotonylation Proteome in Cancer Cells., PMID:39208062
Inhibition of transglutaminase 2 inhibits ionizing radiation-induced cellular senescence in skin keratinocytes in vitro., PMID:39139071
Differential miRNA and Protein Expression Reveals miR-1285, Its Targets TGM2 and CDH-1, as Well as CD166 and S100A13 as Potential New Biomarkers in Patients with Diabetes Mellitus and Pancreatic Adenocarcinoma., PMID:39123454
Combining bioinformatics, network pharmacology and artificial intelligence to predict the target genes of S-ketamine for treating major depressive disorder., PMID:39118379
Transglutaminase 2-mediated histone monoaminylation and its role in cancer., PMID:39115570
Screening of novel disease genes of sepsis-induced myocardial Disfunction by RNA sequencing and bioinformatics analysis., PMID:39111545
Identifying polyamine related biomarkers in diagnosis and treatment of ulcerative colitis by integrating bulk and single-cell sequencing data., PMID:39103474
Serotonylation in tumor-associated fibroblasts contributes to the tumor-promoting roles of serotonin in colorectal cancer., PMID:39097134
Manipulating host secreted protein gene expression: an indirect approach by HPV11/16 E6/E7 to suppress PBMC cytokine secretion., PMID:39095779
TG2 participates in pulmonary vascular remodelling by regulating the senescence of pulmonary artery smooth muscle cells., PMID:39009200
The upregulation of TGM2 is associated with poor prognosis and the shaping of the inflammatory tumor microenvironment in lung squamous cell carcinoma., PMID:39005693
Direct Current Electrical Stimulation Shifts THP-1-Derived Macrophage Polarization towards Pro-Regenerative M2 Phenotype., PMID:39000377
Chemical Proteomic Profiling of Protein Dopaminylation in Colorectal Cancer Cells., PMID:38838187
For research use only. Not for human or drug use.
