Catalog No.
EHK16001
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Pro28-Lys188
Predicted molecular weight
21.71 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9NY25
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
C-type lectin domain family 5 member A, C-type lectin superfamily member 5, Myeloid DAP12-associating lectin 1, MDL-1, CLEC5A, CLECSF5, MDL1
Endothelial CLEC5A drives barrier dysfunction and vascular leakage responsible for lung injury in bacterial pneumonia and sepsis., PMID:40498836
Multiomics profiles of genome-wide alterations in H3K27ac in different lung lobes after acute graft-versus-host disease with MSCs treatment., PMID:40443676
An Updated Review of Potential Drug Targets for Japanese Encephalitis., PMID:40247803
Epigenetic upregulation of CLEC5A contributes to monocyte/macrophage dysfunction in coronary artery disease., PMID:40147659
CSF proteins of inflammation, proteolysis and lipid transport define preclinical AD and progression to AD dementia in cognitively unimpaired individuals., PMID:39523360
The deficient CLEC5A ameliorates the behavioral and pathological deficits via the microglial Aβ clearance in Alzheimer's disease mouse model., PMID:39443966
High-Throughput Transcriptomics Identifies Chemoresistance-Associated Gene Expression Signatures in Human Angiosarcoma., PMID:39409192
Acute blood loss in mice forces differentiation of both CD45-positive and CD45-negative erythroid cells and leads to a decreased CCL3 chemokine production by bone marrow erythroid cells., PMID:39231178
CLEC5A Promotes Neuronal Pyroptosis in Rat Spinal Cord Injury Models by Interacting with TREM1 and Elevating NLRC4 Expression., PMID:39187376
The influence of CLEC5A on early macrophage-mediated inflammation in COPD progression., PMID:39097839
REEP5 mediates the function of CLEC5A to alleviate myocardial infarction by inhibiting endoplasmic reticulum stress-induced apoptosis., PMID:39044150
Identification of core genes shared by ischemic stroke and myocardial infarction using an integrated approach., PMID:38968466
Involvement of Siglec-15 in regulating RAP1/RAC signaling in cytoskeletal remodeling in osteoclasts mediated by macrophage colony-stimulating factor., PMID:38849345
T-reg transcriptomic signatures identify response to check-point inhibitors., PMID:38710724
IL-23 induces CLEC5A+ IL-17A+ neutrophils and elicit skin inflammation associated with psoriatic arthritis., PMID:38301504
Identification of potential biomarkers associated with CD4+ T cell infiltration in myocardial ischemia-reperfusion injury using bioinformation analysis., PMID:37969273
Current and emerging biomarkers for ulcerative colitis., PMID:37933807
Phellopterin attenuates ovarian cancer proliferation and chemoresistance by inhibiting the PU.1/CLEC5A/PI3K-AKT feedback loop., PMID:37708916
Transcriptomic comparison of bone marrow CD34 + cells and peripheral blood neutrophils from ET patients with JAK2 or CALR mutations., PMID:37550636
CLEC5A regulates the proliferation and migration of colon cancer via the AKT/mTOR signaling pathway., PMID:37435201
In-Silico CLEC5A mRNA expression analysis to predict Dengue susceptibility in cancer patients., PMID:37415850
An artificial intelligence prediction model based on extracellular matrix proteins for the prognostic prediction and immunotherapeutic evaluation of ovarian serous adenocarcinoma., PMID:37388244
Six potential biomarkers in septic shock: a deep bioinformatics and prospective observational study., PMID:37359526
Identification of Key Inflammation-related Genes as Potential Diagnostic Biomarkers of Sepsis., PMID:37235492
[Overexpression of CLEC5A inhibits cell proliferation and metastasis and reverses epithelial-mesenchymal transition in hepatocellular carcinoma]., PMID:36856214
Diagnostic and predictive values of pyroptosis-related genes in sepsis., PMID:36817458
Immune cell-specific smoking-related expression characteristics are revealed by re-analysis of transcriptomes from the CEDAR cohort., PMID:36817262
CLEC5A mediates Zika virus-induced testicular damage., PMID:36803804
Interleukin-23 Regulates Inflammatory Osteoclastogenesis via Activation of CLEC5A(+) Osteoclast Precursors., PMID:36787107
Orientia tsutsugamushi Infection Stimulates Syk-Dependent Responses and Innate Cytosolic Defenses in Macrophages., PMID:36678402
The Role of Plasma Cell-Free Mitochondrial DNA and Nuclear DNA in Systemic Lupus Erythematosus., PMID:36624953
CLEC5A expression can be triggered by spike glycoprotein and may be a potential target for COVID-19 therapy., PMID:36571274
Molecular Mechanism and Role of Japanese Encephalitis Virus Infection in Central Nervous System-Mediated Diseases., PMID:36560690
In Silico Design of siRNAs for Silencing CLEC5A Receptor as a Potential Therapeutic Approach Against Dengue and Japanese Encephalitis Virus Infection in Human., PMID:36530559
Development of a novel glycolysis-related genes signature for isocitrate dehydrogenase 1-associated glioblastoma multiforme., PMID:36389748
The transcriptional profiling identifies hub genes in immune subsets of patients with Behçet's syndrome., PMID:36226612
Targeting STAT5 Signaling Overcomes Resistance to IDH Inhibitors in Acute Myeloid Leukemia through Suppression of Stemness., PMID:36150062
CLEC5A is critical in Pseudomonas aeruginosa-induced NET formation and acute lung injury., PMID:36048544
A Pan-Cancer Analysis Reveals CLEC5A as a Biomarker for Cancer Immunity and Prognosis., PMID:35979347
Intestinal Inflammation Promotes MDL-1+ Osteoclast Precursor Expansion to Trigger Osteoclastogenesis and Bone Loss., PMID:35835390
CLEC5A and TLR2 are critical in SARS-CoV-2-induced NET formation and lung inflammation., PMID:35820906
Signature constructed by glycolysis-immune-related genes can predict the prognosis of osteosarcoma patients., PMID:35435626
CLEC5a-directed bispecific antibody for effective cellular phagocytosis., PMID:35293277
Activation of the Innate Immune Checkpoint CLEC5A on Myeloid Cells in the Absence of Danger Signals Modulates Macrophages' Function but Does Not Trigger the Adaptive T Cell Immune Response., PMID:35252461
Characterisation of the Circulating Transcriptomic Landscape in Inflammatory Bowel Disease Provides Evidence for Dysregulation of Multiple Transcription Factors Including NFE2, SPI1, CEBPB, and IRF2., PMID:35212366
Identification of Key Pathways and Establishment of a Seven-Gene Prognostic Signature in Cervical Cancer., PMID:35154316
Revealing potential diagnostic gene biomarkers of septic shock based on machine learning analysis., PMID:35045818
BCL11A promotes myeloid leukemogenesis by repressing PU.1 target genes., PMID:34714913
A human liver cell-based system modeling a clinical prognostic liver signature for therapeutic discovery., PMID:34535664
Genetic loss-of-function of activating transcription factor 3 but not C-type lectin member 5A prevents diabetic peripheral neuropathy., PMID:34172832
For research use only. Not for human or drug use.
