Catalog No.
YHA43201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Thr2-Asp134
Predicted molecular weight
15.84 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O15151
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
MDM4, Mdm2-like p53-binding protein, MDMX, p53-binding protein Mdm4, Protein Mdm4, Protein Mdmx, Double minute 4 protein
Resolving spatial subclonal genomic heterogeneity of loss of heterozygosity and extrachromosomal DNA in gliomas., PMID:40514380
Identification of MDM4 as a Prognostic Biomarker and a Target for Therapeutics in Colorectal Cancer., PMID:40485064
Mechanistic Role of the Mdm2/MdmX Lid Domain in Regulating Their Interactions with p53., PMID:40427535
The Central Role of Ribosomal Proteins in p53 Regulation., PMID:40427096
Epstein-Barr virus nuclear antigen 1 (EBNA1) increases the expression levels of MDM2 and MDM4 genes in HeLa cells: a review on MDM2 and MDM4 roles in cancer., PMID:40382619
OGT Enhances Adriamycin Resistance of Breast Cancer by Promoting Glycolysis through MDM4 Upregulation in an O-GlcNAcylation-Dependent Manner., PMID:40372583
Retinoblastoma: Molecular Evaluation of Tumor Samples, Aqueous Humor, and Peripheral Blood Using a Next-Generation Sequence Panel., PMID:40332023
Strategies for p53 Activation and Targeted Inhibitors of the p53-Mdm2/MdmX Interaction., PMID:40277907
NS3 of hepatitis C virus drives hepatocellular carcinoma progression through a novel RNA-interference pathway., PMID:40226576
Dependence on Mdm2 for Mdm4 inhibition of p53 activity., PMID:40081463
Targeting the MDM2-MDM4 interaction interface reveals an otherwise therapeutically active wild-type p53 in colorectal cancer., PMID:40022459
Preclinical studies and transcriptome analysis in a model of Parkinson's disease with dopaminergic ZNF746 expression., PMID:40022229
Descriptive Comparative Transcriptomic Analysis of Genotype IV SHEV ORF3-Expressing HepG2 Cells., PMID:40005777
Structure and function of MDM2 and MDM4 in health and disease., PMID:39960347
The key vulnerabilities and therapeutic opportunities in the USP7-p53/MDM2 axis in cancer., PMID:39880128
Novel Inhibitors for MDM2-MDM4 E3 Ligase Potently Induce p53-Indepedent Apoptosis in Drug-Resistant Leukemic Cells., PMID:39795242
Ipsilateral Breast Carcinoma Recurrence: True Recurrence or New Primary? A Clinicopathologic and Molecular Study., PMID:39780328
Chemokine CXCL12 Activates CXC Receptor 4 Metastasis Signaling Through the Upregulation of a CXCL12/CXCR4/MDMX (MDM4) Axis., PMID:39766093
Small-molecule MMRi36 induces apoptosis in p53-mutant lymphomas by targeting MDM2/MDM4/XIAP for degradation., PMID:39763603
Comprehensive genomic analysis reveals molecular heterogeneity in pediatric ALK-positive anaplastic large cell lymphoma., PMID:39592809
Gain of 1q confers an MDM4-driven growth advantage to undifferentiated and differentiating hESC while altering their differentiation capacity., PMID:39572522
MDM4 inhibits ferroptosis in p53 mutant colon cancer via regulating TRIM21/GPX4 expression., PMID:39543140
MDM4 exon skipping upon dysfunctional ribosome assembly., PMID:39516053
An update patent review of MDM2-p53 interaction inhibitors (2019-2023)., PMID:39435470
An Anti-Invasive Role for Mdmx through the RhoA GTPase under the Control of the NEDD8 Pathway., PMID:39404389
Rational design, synthesis, and biophysical characterization of a peptidic MDM2-MDM4 interaction inhibitor., PMID:39369567
Upregulation of YPEL3 expression and induction of human breast cancer cell death by microRNAs., PMID:39345743
SNRPB2 promotes triple-negative breast cancer progression by controlling alternative splicing of MDM4 pre-mRNA., PMID:39329452
The nuclear GYF protein CD2BP2/U5-52K is required for T cell homeostasis., PMID:39308865
Design, Synthesis, and Biological Evaluation of Lysine-Stapled Peptide Inhibitors of p53-MDM2/MDMX Interactions with Potent Antitumor Activity In Vivo., PMID:39300610
CEP-1347 Boosts Chk2-Mediated p53 Activation by Ionizing Radiation to Inhibit the Growth of Malignant Brain Tumor Cells., PMID:39273420
Long-Read MDM4 Sequencing Reveals Aberrant Isoform Landscape in Metastatic Melanomas., PMID:39273363
Clinical outcome and prognostic factors for immunotherapy-based treatments in patients with platinum-refractory germ cell tumor., PMID:39236453
Ribosomal RNA transcription governs splicing through ribosomal protein RPL22., PMID:39211199
Genes Co-Expressed with ESR2 Influence Clinical Outcomes in Cancer Patients: TCGA Data Analysis., PMID:39201394
Mdm2 requires Sprouty4 to regulate focal adhesion formation and metastasis independent of p53., PMID:39164253
RPL22 is a tumor suppressor in MSI-high cancers and a splicing regulator of MDM4., PMID:39146182
A defective splicing machinery promotes senescence through MDM4 alternative splicing., PMID:39118304
The ribosomal protein L22 binds the MDM4 pre-mRNA and promotes exon skipping to activate p53 upon nucleolar stress., PMID:39116201
Hdm2 disrupts HdmX-mediated nuclear export of p53 by sequestering it in nucleus., PMID:39069150
Association analysis of indel variants and gene expression identifies MDM4 as a novel locus for skeletal muscle hypertrophy and power athlete status., PMID:39041487
NTRK-fused central nervous system tumours: clinicopathological and genetic insights and response to TRK inhibitors., PMID:39014476
Targeting Hdm2 and Hdm4 in Anticancer Drug Discovery: Implications for Checkpoint Inhibitor Immunotherapy., PMID:38994976
Feeder-free culture of human pluripotent stem cells drives MDM4-mediated gain of chromosome 1q., PMID:38964325
Treatment options for biliary tract cancer: unmet needs, new targets and opportunities from both physicians' and patients' perspectives., PMID:38861288
Structural Adaptation of Secondary p53 Binding Sites on MDM2 and MDMX., PMID:38810774
SETBP1 activation upon MDM4-enhanced ubiquitination of NR3C1 triggers dissemination of colorectal cancer cells., PMID:38796806
Novel 9-Methylanthracene Derivatives as p53 Activators for the Treatment of Glioblastoma Multiforme., PMID:38792257
A feed-forward loop between LncRNA- KCNQ1OT1 and MDM4 promotes metastasis of colorectal cancer., PMID:38749830
Ribosome subunit attrition and activation of the p53-MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition., PMID:38682900
For research use only. Not for human or drug use.
