Catalog No.
FHN10210
Species reactivity
Human, Baboon, Horse, Pig
Host species
Mouse
Isotype
IgG2a, kappa
Clonality
Monoclonal
Conjugation
Unconjugated
Target
C5b-9 Complex, Complement C5b-9 Complex, Complement Component 5b-9
Concentration
1.16 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Applications
ELISA, FCM, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
aE11#
Current Understanding of the Pathogenesis of ANCA-Associated Vasculitis and Novel Treatment Options Targeting Complement Activation., PMID:40430184
The Role of Complement in the Pathogenesis and Treatment of Myasthenia Gravis., PMID:40422242
Ficolin-3 Activates Complement and Triggers Necroptosis in Cholangiocarcinoma Cells via the RIPK1/RIPK3/MLKL Signaling Pathway., PMID:40407231
Inhibition of terminal complement complex formation alleviates murine antibody-mediated TRALI., PMID:40388640
Evidence for Complement Activation in Preeclampsia Placenta and Its Presence in Circulation., PMID:40388260
Thrombospondin-1 inhibits alternative complement pathway activation in antineutrophil cytoplasmic antibody-associated vasculitis., PMID:40338657
The role of complement in the immunopathogenesis of acetylcholine receptor antibody-positive generalized myasthenia gravis: bystander or key player?, PMID:40303417
Complement dysregulation at lymphatics., PMID:40300720
Deposition of complement regulators on the surface of Plasmodium falciparum merozoites depends on the immune status of the host., PMID:40294075
Macrocyclic Peptide Probes for Immunomodulatory Protein CD59: Potent Modulators of Bacterial Toxin Activity and Antibody-Dependent Cytotoxicity., PMID:40272315
Clinical Significance of Immune Deposits and Complement System Activation in FSGS: Findings from the CureGN Study., PMID:40168593
Atypical presentation of H1N1-induced thrombotic microangiopathy with CD46 gene mutation
., PMID:40115863
Claudin-2 enhances human antibody-mediated complement-dependent cytotoxicity of porcine endothelial cells by modulating antibody binding and complement activation., PMID:40040710
Ravulizumab and other complement inhibitors for the treatment of autoimmune disorders., PMID:39983521
Vacuolar myopathy with monoclonal gammopathy and stiffness (VAMMGAS)., PMID:39804003
Complement Activation Profiles Predict Clinical Outcomes in Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease., PMID:39661937
Monocyte/macrophage pyroptosis and C5b-9-induced cyst enlargement in Pkd1-/- mice., PMID:39528237
Serine protease RAYM_01812 (SspA) inhibits complement-mediated killing and monocyte chemotaxis and contributes to virulence of Riemerella anatipestifer in ducks., PMID:39450484
Characterization of the bispecific VHH antibody tarperprumig (ALXN1820) specific for properdin and designed for low-volume administration., PMID:39397258
Unveiling the impact of Leptospira TolC efflux protein on host tissue adherence, complement evasion, and diagnostic potential., PMID:39392312
Ficolin-3 induces apoptosis and suppresses malignant property of hepatocellular carcinoma cells via the complement pathway., PMID:39357793
Case report: Timing of eculizumab treatment in catastrophic antiphospholipid syndrome., PMID:39318635
IgG4 glycosylation contributes to the pathogenesis of IgG4 Hashimoto's thyroiditis via the complement pathway., PMID:39316722
Enhanced complement activation and MAC formation accelerates severe COVID-19., PMID:39284944
Elevated C1s/C1-INH in serum and plasma of myasthenia gravis patients., PMID:39255718
Brain-penetrant complement inhibition mitigates neurodegeneration in an Alzheimer's disease mouse model., PMID:39215579
C4d, rather than C3d and C5b-9, Is Associated with Graft Loss in Recurrent IgA Deposition after Kidney Transplantation., PMID:39154645
Different Complement Activation Patterns Following C5 Cleavage in MOGAD and AQP4-IgG+NMOSD., PMID:39133885
Visualization and characterization of complement activation in acetylcholine receptor antibody seropositive myasthenia gravis., PMID:39115039
CD59 Protects Primary Human Cerebrovascular Smooth Muscle Cells from Cytolytic Membrane Attack Complex., PMID:38928601
"Eculizumab First" in the Management of Posttransplant Thrombotic Microangiopathy., PMID:38765562
DNA Nanostructure-Templated Antibody Complexes Provide Insights into the Geometric Requirements of Human Complement Cascade Activation., PMID:38703132
CD59 Protects Primary Human Cerebrovascular Smooth Muscle Cells from Cytolytic Membrane Attack Complex., PMID:38645247
Humanization of a mouse anti-human complement C6 monoclonal antibody as a potential therapeutic for certain complement-mediated diseases., PMID:38598870
[The complement cascade in renal pathology]., PMID:38578365
In a novel autoimmune and high-pressure glaucoma model a complex immune response is induced., PMID:38515755
Targeting terminal pathway reduces brain complement activation, amyloid load and synapse loss, and improves cognition in a mouse model of dementia., PMID:38485063
Pharmacodynamics and Mechanism of Astragali Radix and Anemarrhenae Rhizoma in Treating Chronic Heart Failure by Inhibiting Complement Activation., PMID:38386515
Acute neutrophilic vasculitis (leukocytoclasia) in 36 COVID-19 autopsy brains., PMID:38360666
Complement C7 and clusterin form a complex in circulation., PMID:38333209
In vitro characterization of rare anti-αIIbβ3 isoantibodies produced by patients with Glanzmann thrombasthenia that severely block fibrinogen binding and generate procoagulant platelets via complement activation., PMID:38268518
Complement in breast milk modifies offspring gut microbiota to promote infant health., PMID:38242132
C3aR-initiated signaling is a critical mechanism of podocyte injury in membranous nephropathy., PMID:38227377
ERK1/2-dependent activity of SOX9 is required for sublytic C5b-9-induced expression of FGF1, PDGFα, and TGF-β1 in rat Thy-1 nephritis., PMID:38118314
Ravulizumab in Myasthenia Gravis: A Review of the Current Evidence., PMID:38059203
Antibacterial Activity of Rainbow Trout Plasma: In Vitro Assays and Proteomic Analysis., PMID:38003182
A Complement to Traditional Treatments for Antibody-Mediated Rejection? Use of Eculizumab in Lung Transplantation: A Review and Early Center Experience., PMID:37994573
Modeling complement activation on human glomerular microvascular endothelial cells., PMID:37954621
Artificial surface labelling of Escherichia coli with StrepTagII antigen to study how monoclonal antibodies drive complement-mediated killing., PMID:37914798
Preclinical efficacy of a cell division protein candidate gonococcal vaccine identified by artificial intelligence., PMID:37905891
For research use only. Not for human or drug use.
