Anti-Mouse VSIR/VISTA Polyclonal Antibody

Catalog No.

PMK06901

Species reactivity

Mouse

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Mouse VSIR/VISTA (Ala32-Asn181).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

V-type immunoglobulin domain-containing suppressor of T-cell activation (Platelet receptor Gi24) (V-set domain-containing immunoregulatory receptor) (V-set immunoregulatory receptor)

Purification

Purified by antigen affinity column.

Accession

Q9D659

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Discovery of bifunctional small molecules targeting PD-L1/VISTA with favorable pharmacokinetics for cancer immunotherapy., PMID:40049048

Targeting cell-surface VISTA expression on allospecific naïve T cells promotes tolerance., PMID:39919264

YAP/TEAD4/SP1-induced VISTA expression as a tumor cell-intrinsic mechanism of immunosuppression in colorectal cancer., PMID:39875519

VISTA in hematological malignancies: a review of the literature., PMID:39742253

Small molecule inhibitors targeting PD-L1, CTLA4, VISTA, TIM-3, and LAG3 for cancer immunotherapy (2020-2024)., PMID:39653621

V-domain immunoglobulin suppressor of T-cell activation and programmed death receptor 1 dual checkpoint blockade enhances antitumour immunity and survival in glioblastoma., PMID:39626657

Immune checkpoint expression on tumor-infiltrating lymphocytes (TIL) is dependent on HPV status in oropharyngeal carcinoma (OPSCC) - A single-cell RNA sequencing analysis., PMID:39549431

Immune Checkpoint VISTA Negatively Regulates Microglia Glycolysis and Activation via TRIM28-Mediated Ubiquitination of HK2 in Sepsis-Associated Encephalopathy., PMID:39455538

Multiplexed Spatial Imaging at the Single-Cell Level Reveals Mutually Exclusive Expression of B7 Family Proteins., PMID:39244158

Targeting of immune checkpoint regulator V-domain Ig suppressor of T-cell activation (VISTA) with 89Zr-labelled CI-8993., PMID:39060374

Aberrant expression of B7-H4 and B7-H5 contributes to the development of cutaneous squamous cell carcinoma., PMID:38850312

Repositioning baloxavir marboxil as VISTA agonist that ameliorates experimental asthma., PMID:38340268

PD-1H/VISTA mediates immune evasion in acute myeloid leukemia., PMID:38060328

VISTA blockade alleviates immunosuppression of MDSCs in oral squamous cell carcinoma., PMID:37907049

Imatinib and M351-0056 enhance the function of VISTA and ameliorate the development of SLE via IFN-I and noncanonical NF-κB pathway., PMID:37804401

Enhancement of Radiation Therapy through Blockade of the Immune Checkpoint, V-domain Ig Suppressor of T Cell Activation (VISTA), in Melanoma and Adenocarcinoma Murine Models., PMID:37762046

The immune checkpoint VISTA is associated with prognosis in patients with malignant uveal melanoma., PMID:37662962

Immune-checkpoint protein VISTA in allergic, autoimmune disease and transplant rejection., PMID:37435070

VISTA expression and patient selection for immune-based anticancer therapy., PMID:36891296

Immune checkpoint receptor VISTA on immune cells is associated with expression of T-cell exhaustion marker TOX and worse prognosis in renal cell carcinoma with venous tumor thrombus., PMID:36042047

Distinct immune stimulatory effects of anti-human VISTA antibodies are determined by Fc-receptor interaction., PMID:35967294

Different clinical significance of novel B7 family checkpoints VISTA and HHLA2 in human lung adenocarcinoma., PMID:35187955

Kidney VISTA prevents IFN-γ/IL-9 axis-mediated tubulointerstitial fibrosis after acute glomerular injury., PMID:34752423

VISTA Blockade Aggravates Bone Loss in Experimental Murine Apical Periodontitis., PMID:34691045

Immune related endonucleases and GTPases are not associated with tumor response in patients with advanced non-small cell lung cancer treated with checkpoint inhibitors., PMID:34673351

VISTA Stimulation of VSIG4-Positive Macrophages Strongly Suppresses T Cell Proliferation via Excessive Nitric Oxide Production in Sepsis., PMID:34433706

VISTA facilitates phagocytic clearance of HIV infected CEM-SS T cells., PMID:34401556

High-Affinity Anti-VISTA Antibody Protects against Sepsis by Inhibition of T Lymphocyte Apoptosis and Suppression of the Inflammatory Response., PMID:34366711

VISTA is an activating receptor in human monocytes., PMID:34106206

VISTA and PD-L1 synergistically predict poor prognosis in patients with extranodal natural killer/T-cell lymphoma., PMID:33889438

Structural Basis of VSIG3: The Ligand for VISTA., PMID:33841409

VISTA: A Target to Manage the Innate Cytokine Storm., PMID:33643285

Prognostic significance and therapeutic potential of the immune checkpoint VISTA in pancreatic cancer., PMID:33237432

VISTA Re-programs Macrophage Biology Through the Combined Regulation of Tolerance and Anti-inflammatory Pathways., PMID:33178206

Converging focal radiation and immunotherapy in a preclinical model of triple negative breast cancer: contribution of VISTA blockade., PMID:33150045

An engineered antibody binds a distinct epitope and is a potent inhibitor of murine and human VISTA., PMID:32938950

The prognostic significance of VISTA and CD33-positive myeloid cells in cutaneous melanoma and their relationship with PD-1 expression., PMID:32873829

VISTA deficiency protects from immune complex-mediated glomerulonephritis by inhibiting neutrophil activation., PMID:32586651

Potential Therapeutic Targets of B7 Family in Colorectal Cancer., PMID:32477326

The polymorphism rs975484 in the protein arginine methyltransferase 1 gene modulates expression of immune checkpoint genes in hepatocellular carcinoma., PMID:32245889

The expression and immunoregulation of immune checkpoint molecule VISTA in autoimmune diseases and cancers., PMID:32057701

VISTA is a checkpoint regulator for naïve T cell quiescence and peripheral tolerance., PMID:31949051

VISTA: Coming of age as a multi-lineage immune checkpoint., PMID:31930484

PD-1H (VISTA)-mediated suppression of autoimmunity in systemic and cutaneous lupus erythematosus., PMID:31826980

Acidity changes immunology: a new VISTA pathway., PMID:31822869

VISTA is an acidic pH-selective ligand for PSGL-1., PMID:31645726

Structure and Functional Binding Epitope of V-domain Ig Suppressor of T Cell Activation., PMID:31484064

CA-170 - A Potent Small-Molecule PD-L1 Inhibitor or Not?, PMID:31374878

Inhibition of allogeneic islet graft rejection by VISTA-conjugated liposome., PMID:31272717

Hypoxia-Induced VISTA Promotes the Suppressive Function of Myeloid-Derived Suppressor Cells in the Tumor Microenvironment., PMID:31088847

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