Catalog No.
PMG78801
Species reactivity
Mouse
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Mouse LRRC32/GARP (Cys27-Asn276).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
Transforming growth factor beta activator LRRC32 (Garpin) (Glycoprotein A repetitions predominant) (GARP) (Leucine-rich repeat-containing protein 32)
Purification
Purified by antigen affinity column.
Accession
G3XA59
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Discovery and preclinical evaluation of BPB-101: a novel triple functional bispecific antibody targeting GARP-TGF-β complex/SLC, free TGF-β and PD-L1., PMID:39635528
The CALR mutations enhance the expression of the immunosuppressive proteins GARP and LAP on peripheral blood lymphocytes through increased binding of activated platelets., PMID:39161981
Suppression of lysosome metabolism-meditated GARP/TGF-β1 complexes specifically depletes regulatory T cells to inhibit breast cancer metastasis., PMID:38698265
A novel GARP humanized mouse model for efficacy assessment of GARP-targeting therapies., PMID:38442579
TGF-β Score based on Silico Analysis can Robustly Predict Prognosis and Immunological Characteristics in Lower-grade Glioma: The Evidence from Multicenter Studies., PMID:37718518
Anti-GARP Antibodies Inhibit Release of TGF-β by Regulatory T Cells via Different Modes of Action, but Do Not Influence Their Function In Vitro., PMID:36928178
Analysis of LAP+ and GARP+ Treg subsets in peripheral blood of patients with neuromyelitis optica spectrum disorders., PMID:36683084
New insight into GARP striking role in cancer progression: application for cancer therapy., PMID:36460874
Selective targeting of GARP-LTGFβ axis in the tumor microenvironment augments PD-1 blockade via enhancing CD8+ T cell antitumor immunity., PMID:36096533
Blocking GARP-mediated activation of TGF-β1 did not alter innate or adaptive immune responses to bacterial infection or protein immunization in mice., PMID:34973084
Novel aspects of regulatory T cell dysfunction as a therapeutic target in giant cell arteritis., PMID:34583923
Functional Th1-oriented T follicular helper cells that infiltrate human breast cancer promote effective adaptive immunity., PMID:34411002
Combined Blockade of GARP:TGF-β1 and PD-1 Increases Infiltration of T Cells and Density of Pericyte-Covered GARP+ Blood Vessels in Mouse MC38 Tumors., PMID:34386010
Novel anti-GARP antibody DS-1055a augments anti-tumor immunity by depleting highly suppressive GARP+ regulatory T cells., PMID:34235533
Expression of Leucine-rich Repeat-containing Protein 32 Following Lymphocyte Stimulation in Patients with Non-IgE-mediated Gastrointestinal Food Allergies., PMID:33380925
Selective inhibition of TGF-β1 produced by GARP-expressing Tregs overcomes resistance to PD-1/PD-L1 blockade in cancer., PMID:32917858
CD52-negative T cells predict acute graft-versus-host disease after an alemtuzumab-based conditioning regimen., PMID:32410220
Genetic variants of the C11orf30-LRRC32 region are associated with childhood asthma in the Chinese population., PMID:31812328
Glycoprotein A (GARP) in children who outgrow food allergy., PMID:31477391
GARP as an Immune Regulatory Molecule in the Tumor Microenvironment of Glioblastoma Multiforme., PMID:31357555
Novel biomarkers for primary biliary cholangitis to improve diagnosis and understand underlying regulatory mechanisms., PMID:31033124
Structural basis of latent TGF-β1 presentation and activation by GARP on human regulatory T cells., PMID:30361387
Deletion of GARP on mouse regulatory T cells is not sufficient to inhibit the growth of transplanted tumors., PMID:30093071
IGHG, IGKC, and FCGR genes and endogenous antibody responses to GARP in patients with breast cancer and matched controls., PMID:29879453
B lymphocytes confer immune tolerance via cell surface GARP-TGF-β complex., PMID:29618665
Blocking immunosuppression by human Tregs in vivo with antibodies targeting integrin αVβ8., PMID:29109269
Cutting Edge: Active TGF-β1 Released from GARP/TGF-β1 Complexes on the Surface of Stimulated Human B Lymphocytes Increases Class-Switch Recombination and Production of IgA., PMID:28607112
IL-6 Inhibits Upregulation of Membrane-Bound TGF-β 1 on CD4+ T Cells and Blocking IL-6 Enhances Oral Tolerance., PMID:28039301
Surface Expression of TGFβ Docking Receptor GARP Promotes Oncogenesis and Immune Tolerance in Breast Cancer., PMID:27913437
How Soluble GARP Enhances TGFβ Activation., PMID:27054568
GARP inhibits allergic airway inflammation in a humanized mouse model., PMID:26990894
[Immunosuppression by Treg can be decreased with anti-GARP antibodies]., PMID:26481020
Activated glycoprotein A repetitions predominant (GARP)-expressing regulatory T cells inhibit allergen-induced intestinal inflammation in humanized mice., PMID:26145987
Monoclonal antibodies against GARP/TGF-β1 complexes inhibit the immunosuppressive activity of human regulatory T cells in vivo., PMID:25904740
miR-142-3p is involved in CD25+ CD4 T cell proliferation by targeting the expression of glycoprotein A repetitions predominant., PMID:23650616
The C11orf30-LRRC32 region is associated with total serum IgE levels in asthmatic patients., PMID:22070912
Regulatory T cells with reduced repressor capacities are extensively amplified in pulmonary sarcoid lesions and sustain granuloma formation., PMID:21482483
TGF-β induces surface LAP expression on murine CD4 T cells independent of Foxp3 induction., PMID:21124798
Membrane protein GARP is a receptor for latent TGF-beta on the surface of activated human Treg., PMID:19750484
For research use only. Not for human or drug use.
