Catalog No.
PMF88301
Species reactivity
Mouse
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Mouse IL1RL1/ST2 (Ser27-Arg332).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
Interleukin-1 receptor-like 1 (EC 3.2.2.6) (Interleukin-33 receptor alpha chain) (Lymphocyte antigen 84) (Protein ST2) (Protein T1)
Purification
Purified by antigen affinity column.
Accession
P14719
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Enhancing the Affinity of a Novel Selective scFv for Soluble ST2 through Computational Design., PMID:40417773
Fluorescence Aptasensor for sST2 Detection Using In Vitro Selected Aptamers., PMID:40370093
Drug survival of omalizumab in atopic asthma: Impact of clinical and genetic variables., PMID:40189906
A novel optical fiber immunosensor for detection of heart failure marker ST2 based on MoS2-modified D-shaped ExTFG., PMID:40120516
Soluble ST2 is an early marker and treatment target for hypertensive nephrosclerosis signatured in glomerular mesangial cells., PMID:40096886
IL-33 protects from recurrent C. difficile infection by restoration of humoral immunity., PMID:40048372
IL-33 signaling is dispensable for the IL-10-induced enhancement of mast cell responses during food allergy., PMID:39935481
IL-33/ST2 axis in diverse diseases: regulatory mechanisms and therapeutic potential., PMID:39925809
IL-33/ST2 axis mediates diesel exhaust particles-induced mast cell activation., PMID:39707175
Group 2 innate lymphoid cells are a non-redundant source of interleukin-5 required for development and function of murine B1 cells., PMID:39632879
Dural Tregs driven by astrocytic IL-33 mitigate depression through the EGFR signals in mPFC neurons., PMID:39592709
Interleukin-33 Deficiency Protects the Skin From Ulcer Formation in an Ischemia-Reperfusion-Induced Decubitus Mouse Model., PMID:39555678
IL-33/ST2 enhances MMP-12 expression by macrophages to mediate inflammatory and immune response in IgG4-Related Ophthalmic Disease., PMID:39299101
A model-based approach using GSK3772847, an anti-interleukin-33 receptor monoclonal antibody, as a showcase to predict SC administration PK and free target dynamics based on PK and total target measurements after IV administration., PMID:39258338
Population pharmacokinetic/target engagement modelling of tozorakimab in healthy volunteers and patients with chronic obstructive pulmonary disease., PMID:39183511
Edwardsiella tarda induces airways inflammation and production of autoantibodies against lung tissues through regulation of the IL-33-ST2 axis., PMID:39126327
SingleNucleotide Polymorphisms as Biomarkers of Mepolizumab and Benralizumab Treatment Response in Severe Eosinophilic Asthma., PMID:39125709
ILC2s induce Treg but not Th2-type immunity through IL-33/ST2 pathway in pulmonary tuberculosis., PMID:38990986
The IL-33-ST2 axis plays a vital role in endometriosis via promoting epithelial-mesenchymal transition by phosphorylating β-catenin., PMID:38858740
Maintenance of caecal homeostasis by diverse adaptive immune cells in the rhesus macaque., PMID:38707998
Hydrangea serrata extract attenuates PM-exacerbated airway inflammation in the CARAS model by modulating the IL-33/ST2/NF-κB signaling pathway., PMID:38631146
Multiplex Proteomics in the Identification of Potential Biomarkers of Very Severe Sinusoidal Obstruction Syndrome/Veno-Occlusive Disease in Allogeneic Hematopoietic Cell Transplant Patients Treated with Defibrotide., PMID:38330921
ST2-Mediated Neutrophilic Airway Inflammation: A Therapeutic Target for Patients With Uncontrolled Asthma., PMID:38262389
Interleukin-33/ST2 axis involvement in atrial remodeling and arrhythmogenesis., PMID:38244770
Strategies targeting IL-33/ST2 axis in the treatment of allergic diseases., PMID:37981174
Oxidised IL-33 drives COPD epithelial pathogenesis via ST2-independent RAGE/EGFR signalling complex., PMID:37442582
Influence of Genetics on the Response to Omalizumab in Patients with Severe Uncontrolled Asthma with an Allergic Phenotype., PMID:37108192
Interleukin-33 Mediates Cardiomyopathy After Acute Kidney Injury by Signaling to Cardiomyocytes., PMID:36695175
A comparative study of IL-33 and its receptor ST2 in a C57BL/6 J mouse model of pulmonary Cryptococcus neoformans infection., PMID:36367554
Phase 2 randomized clinical trial of astegolimab in patients with moderate to severe atopic dermatitis., PMID:36041655
IL11 Stimulates IL33 Expression and Proinflammatory Fibroblast Activation across Tissues., PMID:36012165
IL-33/ST2 axis contributes to the dermal fibrosis of systemic sclerosis via promoting fibroblasts activation., PMID:35940987
Interleukin-33 (IL-33): A critical review of its biology and the mechanisms involved in its release as a potent extracellular cytokine., PMID:35640416
A rapid and quantitative detection method for plasma soluble growth stimulating gene protein 2 based on time resolved fluorescence immunochromatography., PMID:35608240
Increased expression of IL1-RL1 is associated with type 2 and type 1 immune pathways in asthma., PMID:35578178
IL-25 blockade augments antiviral immunity during respiratory virus infection., PMID:35508632
The Merkel Cell Polyomavirus T-Antigens and IL-33/ST2-IL1RAcP Axis: Possible Role in Merkel Cell Carcinoma., PMID:35409061
Mast Cells Differentiated in Synovial Fluid and Resident in Osteophytes Exalt the Inflammatory Pathology of Osteoarthritis., PMID:35008966
Blockade or deficiency of PD-L1 expression in intestinal allograft accelerates graft tissue injury in mice., PMID:34679256
Gut Microbial Metabolite Pravastatin Attenuates Intestinal Ischemia/Reperfusion Injury Through Promoting IL-13 Release From Type II Innate Lymphoid Cells via IL-33/ST2 Signaling., PMID:34650552
Inhibition of NF-κB/IL-33/ST2 Axis Ameliorates Acute Bronchiolitis Induced by Respiratory Syncytial Virus., PMID:34395633
Role of the IL33 and IL1RL1 pathway in the pathogenesis of Immunoglobulin A vasculitis., PMID:34373564
Safety and efficacy of itepekimab in patients with moderate-to-severe COPD: a genetic association study and randomised, double-blind, phase 2a trial., PMID:34302758
Astegolimab (anti-ST2) efficacy and safety in adults with severe asthma: A randomized clinical trial., PMID:33872652
The IL33 receptor ST2 contributes to mechanical hypersensitivity in mice with neuropathic pain., PMID:33596932
Role of the IL-33/ST2 axis in cigarette smoke-induced airways remodelling in chronic obstructive pulmonary disease., PMID:33589512
Endothelial cells response to neutrophil-derived extracellular vesicles miRNAs in anti-PR3 positive vasculitis., PMID:33527387
Persistence of mature dendritic cells, TH2A, and Tc2 cells characterize clinically resolved atopic dermatitis under IL-4Rα blockade., PMID:33483337
Nuclear IL-33 restrains the early conversion of fibroblasts to an extracellular matrix-secreting phenotype., PMID:33420328
Development of a Novel Homogeneous Nanoparticle-Based Assay for Rapid and High-Throughput Quantitation of the sST2 Protein in Human Serum., PMID:33408473
For research use only. Not for human or drug use.
