Catalog No.
PME61401
Species reactivity
Mouse
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Mouse CCN3 (Ser50-Arg137).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
CCN family member 3 (Cellular communication network factor 3) (Nephroblastoma-overexpressed gene protein homolog) (Protein NOV homolog) (NovH)
Purification
Purified by antigen affinity column.
Accession
Q64299
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Cellular communication network factor 3 contributes to the pathological process of rheumatoid arthritis through promoting cell senescence and osteoclastogenesis in the joint., PMID:39549484
Blocking CCN2 Reduces Established Palmar Neuromuscular Fibrosis and Improves Function Following Repetitive Overuse Injury., PMID:37762168
Association between endothelin-1 and systemic lupus erythematosus: insights from a case-control study., PMID:37749230
Targeting CCN2 protects against progressive non-alcoholic steatohepatitis in a preclinical model induced by high-fat feeding and type 2 diabetes., PMID:35038159
RFX1-mediated CCN3 induction that may support chondrocyte survival under starved conditions., PMID:33655492
CCN3 is dynamically regulated by treatment and disease state in multiple sclerosis., PMID:33222687
Prostate cancer-secreted CCN3 uses the GSK3β and β-catenin pathways to enhance osteogenic factor levels in osteoblasts., PMID:33107671
Dynamic CCN3 expression in the murine CNS does not confer essential roles in myelination or remyelination., PMID:32651278
Higher Serum CCN3 Is Associated with Disease Activity and Inflammatory Markers in Rheumatoid Arthritis., PMID:32455138
Slow train coming: an anti-CCN2 strategy reverses a model of chronic overuse muscle fibrosis., PMID:32410169
Blocking CTGF/CCN2 reduces established skeletal muscle fibrosis in a rat model of overuse injury., PMID:32227398
Connective tissue growth factor (CCN2) is a matricellular preproprotein controlled by proteolytic activation., PMID:30262666
Reduced immunohistochemical expression of CCN3 in vitiligo., PMID:29998862
Prevalence of Coxiella burnetii in cattle at South Korean national breeding stock farms., PMID:28493973
Prostate cancer-derived CCN3 induces M2 macrophage infiltration and contributes to angiogenesis in prostate cancer microenvironment., PMID:24721786
Cyr61/CTGF/Nov family proteins in gastric carcinogenesis., PMID:24587648
CCN3 promotes prostate cancer bone metastasis by modulating the tumor-bone microenvironment through RANKL-dependent pathway., PMID:23536580
CCN4 induces vascular cell adhesion molecule-1 expression in human synovial fibroblasts and promotes monocyte adhesion., PMID:23313051
Flaws in the peer-reviewing process : a critical look at a recent paper studying the role of CCN3 in renal cell carcinoma., PMID:22865264
Roles of heterotypic CCN2/CTGF-CCN3/NOV and homotypic CCN2-CCN2 interactions in expression of the differentiated phenotype of chondrocytes., PMID:22812570
CCN3 increases BMP-4 expression and bone mineralization in osteoblasts., PMID:21898398
CCN3 impairs osteoblast and stimulates osteoclast differentiation to favor breast cancer metastasis to bone., PMID:21514448
CCN3 increases cell motility and MMP-13 expression in human chondrosarcoma through integrin-dependent pathway., PMID:21344378
Nephroblastoma overexpressed gene (NOV) enhances cell motility and COX-2 upregulation of human osteosarcoma involves αvβ5 integrin, ILK and AP-1-dependent pathways., PMID:21145881
CCN3 inhibits neointimal hyperplasia through modulation of smooth muscle cell growth and migration., PMID:20139355
Prognostic relevance of CCN3 in Ewing sarcoma., PMID:19695675
CCN3 and bone marrow cells., PMID:19626464
Domain-specific CCN3 antibodies as unique tools for structural and functional studies., PMID:18481200
Expression of CCN3 protein in human Wilms' tumors: immunohistochemical detection of CCN3 variants using domain-specific antibodies., PMID:18066593
Nephroblastoma overexpressed/cysteine-rich protein 61/connective tissue growth factor/nephroblastoma overexpressed gene-3 (NOV/CCN3), a selective adrenocortical cell proapoptotic factor, is down-regulated in childhood adrenocortical tumors., PMID:17566092
Antiproliferative activity of CCN3: involvement of the C-terminal module and post-translational regulation., PMID:17340618
Potential cellular conformations of the CCN3(NOV) protein., PMID:15361251
Adhesion of endothelial cells to NOV is mediated by the integrins alphavbeta3 and alpha5beta1., PMID:12902636
Identification of a novel integrin alpha 6 beta 1 binding site in the angiogenic inducer CCN1 (CYR61)., PMID:12826661
Immunocytochemical localization of NOVH protein and ultrastructural characteristics of NCI-H295R cells., PMID:11846094
Nuclear localisation of NOVH protein: a potential role for NOV in the regulation of gene expression., PMID:10474687
Binding properties and distribution of insulin-like growth factor binding protein-related protein 3 (IGFBP-rP3/NovH), an additional member of the IGFBP Superfamily., PMID:10084601
For research use only. Not for human or drug use.
