Catalog No.
PHC82501
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human C7/Complement component C7 (Glu569-Asn693).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
C7, Complement component C7
Purification
Purified by antigen affinity column.
Accession
P10643
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Enhanced complement activation and MAC formation accelerates severe COVID-19., PMID:39284944
Targeting terminal pathway reduces brain complement activation, amyloid load and synapse loss, and improves cognition in a mouse model of dementia., PMID:38485063
Intravenous gentamicin therapy induces functional type VII collagen in patients with recessive dystrophic epidermolysis bullosa: an open-label clinical trial., PMID:38366625
Complement C7 and clusterin form a complex in circulation., PMID:38333209
Neutrophil-Specific Syk Expression Is Crucial for Skin Disease in Experimental Epidermolysis Bullosa Acquisita., PMID:36641133
Terminal complement pathway activation drives synaptic loss in Alzheimer's disease models., PMID:35794654
In vivo topical gene therapy for recessive dystrophic epidermolysis bullosa: a phase 1 and 2 trial., PMID:35347281
Validation in the ESPOIR cohort of vitamin K-dependent protein S (PROS) as a potential biomarker capable of predicting response to the methotrexate/etanercept combination., PMID:35313956
Phospholipase Cγ2 Is Essential for Experimental Models of Epidermolysis Bullosa Acquisita., PMID:34656615
CTLA-4 blockade and interferon-α induce proinflammatory transcriptional changes in the tumor immune landscape that correlate with pathologic response in melanoma., PMID:33428680
Preparing for Life: Plasma Proteome Changes and Immune System Development During the First Week of Human Life., PMID:33329546
Development of an anti-human complement C6 monoclonal antibody that inhibits the assembly of membrane attack complexes., PMID:32396613
Combined with anti-Nogo-A antibody treatment, BDNF did not compensate the extra deleterious motor effect caused by large size cervical cord hemisection in adult macaques., PMID:31418518
[Bullous pemphigoid on a healed herpes zoster : A rare example of an isotopic response]., PMID:31236629
The utility of complement assays in clinical immunology: A comprehensive review., PMID:30391025
Efficacy of Human Placental-Derived Stem Cells in Collagen VII Knockout (Recessive Dystrophic Epidermolysis Bullosa) Animal Model., PMID:29745997
Internalization of CD239 highly expressed in breast cancer cells: a potential antigen for antibody-drug conjugates., PMID:29700410
The Syk Tyrosine Kinase Is Required for Skin Inflammation in an In Vivo Mouse Model of Epidermolysis Bullosa Acquisita., PMID:28576735
A Fatal Case of Invasive Infection Caused By W135 Neisseria meningitidis in a Vaccinated French Soldier., PMID:27849512
Two routes of infection with Photobacterium damselae subsp. piscicida are effective in the modulation of the transcription of immune related genes in Solea senegalensis., PMID:27590420
Target deletion of complement component 9 attenuates antibody-mediated hemolysis and lipopolysaccharide (LPS)-induced acute shock in mice., PMID:27444648
Heat differentiated complement factor profiling., PMID:26047714
A heterodimer of a VHH (variable domains of camelid heavy chain-only) antibody that inhibits anthrax toxin cell binding linked to a VHH antibody that blocks oligomer formation is highly protective in an anthrax spore challenge model., PMID:25564615
Defining the complement biomarker profile of C3 glomerulopathy., PMID:25341722
Purification of a novel fibronectin binding protein from 'Granulicatella para-adiacens'., PMID:30979336
Assembly and regulation of the membrane attack complex based on structures of C5b6 and sC5b9., PMID:22832194
Germline variation in complement genes and event-free survival in follicular and diffuse large B-cell lymphoma., PMID:22718493
Meningococcal polysaccharide vaccine failure in a patient with C7 deficiency and a decreased anti-capsular antibody response., PMID:22634438
Late onset myasthenia gravis is associated with HLA DRB1*15:01 in the Norwegian population., PMID:22590574
β-Actin-binding complementarity-determining region 2 of variable heavy chain from monoclonal antibody C7 induces apoptosis in several human tumor cells and is protective against metastatic melanoma., PMID:22334655
Epidermolysis bullosa acquisita., PMID:22137228
Epidermolysis bullosa acquisita: autoimmunity to anchoring fibril collagen., PMID:21955050
Off to a slow start: under-development of the complement system in term newborns is more substantial following premature birth., PMID:21868122
Complement factor 7 gene mutations in relation to meningococcal infection and clinical recurrence of meningococcal disease., PMID:19931914
Monoclonal antibody-mediated inhibition of adhesion of Candida albicans and Candida dubliniensis to human epithelial cells., PMID:19627362
Giardia duodenalis: adhesion-deficient clones have reduced ability to establish infection in Mongolian gerbils., PMID:18456259
Classical pathway evaluation., PMID:18432714
Fungicidal monoclonal antibody C7 binds to Candida albicans Als3., PMID:17452471
Hereditary complement C7 deficiency in nine families: subtotal C7 deficiency revisited., PMID:17407100
Identification of disialic acid-containing glycoproteins in mouse serum: a novel modification of immunoglobulin light chains, vitronectin, and plasminogen., PMID:16608914
Decreased survival of mosquito cells after stable transfection with a Drosophila ecdysteroid response element: possible involvement of a 40 kDa DNA binding protein., PMID:15455055
Inhibition of adherence of Candida albicans and Candida dubliniensis to a resin composite restorative dental material by salivary secretory IgA and monoclonal antibodies., PMID:14996277
Critical role of the complement system in group B streptococcus-induced tumor necrosis factor alpha release., PMID:14573654
Effects of abscisic acid, low temperature, and plant age on cytoskeleton and phosphorylated proteins., PMID:12943513
Serum-resistant strains of Borrelia burgdorferi evade complement-mediated killing by expressing a CD59-like complement inhibitory molecule., PMID:12626580
Cell association of liposomes with high fluid anionic phospholipid content is mediated specifically by LDL and its receptor, LDLr., PMID:11977099
Complement factor I deficiency associated with recurrent meningitis coinciding with menstruation., PMID:11709004
Phylogenetic aspects of the complement system., PMID:11602194
Streptococcal inhibitor of complement (SIC) inhibits the membrane attack complex by preventing uptake of C567 onto cell membranes., PMID:11454069
New biological function of bovine alpha-lactalbumin: protective effect against ethanol- and stress-induced gastric mucosal injury in rats., PMID:11440124
For research use only. Not for human or drug use.
