Catalog No.
FHA14120
Species reactivity
Human, Monkey
Host species
Mouse
Isotype
IgG2a, kappa
Clonality
Monoclonal
Conjugation
Unconjugated
Target
AWAL, Transmembrane protein deleted in VCFS, TMVCF, TMDVCF, Claudin-5, CLDN5
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
O00501
Applications
ELISA, FCM
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.09% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
M11
Neurons enhance blood-brain barrier function via upregulating claudin-5 and VE-cadherin expression due to glial cell line-derived neurotrophic factor secretion., PMID:39475379
Modeling of Blood-Brain Barrier (BBB) Dysfunction and Immune Cell Migration Using Human BBB-on-a-Chip for Drug Discovery Research., PMID:38928202
Potential Therapeutic Strategies and Drugs That Target Vascular Permeability in Severe Infectious Diseases., PMID:38432910
Tocilizumab promotes repair of spinal cord injury by facilitating the restoration of tight junctions between vascular endothelial cells., PMID:36624478
Angelica sinensis polysaccharide improves rheumatoid arthritis by modifying the expression of intestinal Cldn5, Slit3 and Rgs18 through gut microbiota., PMID:35318077
Relationship between blood-brain permeability and antibodies against aquaporins in neuromyelitis optica spectrum disorders and multiple sclerosis patients., PMID:35029294
Safety and efficacy of an anti-claudin-5 monoclonal antibody to increase blood-brain barrier permeability for drug delivery to the brain in a non-human primate., PMID:34118338
The impact of deoxynivalenol contaminated diet on performance, immune response, intestine morphology and jejunal gene expression in broiler chicken., PMID:34111455
Serotonin/5-HT1A Signaling in the Neurovascular Unit Regulates Endothelial CLDN5 Expression., PMID:33383868
Claudin-5 Redistribution Induced by Inflammation Leads to Anti-VEGF-Resistant Diabetic Macular Edema., PMID:32139595
Effect of bevacizumab on the tight junction proteins of vascular endothelial cells., PMID:31632528
Shear stress modulates inner blood retinal barrier phenotype., PMID:31394104
Ferroportin-mediated iron export from vascular endothelial cells in retina and brain., PMID:31323276
Large-Scale Single-Cell RNA-Seq Reveals Molecular Signatures of Heterogeneous Populations of Human Induced Pluripotent Stem Cell-Derived Endothelial Cells., PMID:29986945
Engineered membrane protein antigens successfully induce antibodies against extracellular regions of claudin-5., PMID:29849184
An ECV304 monoculture model for permeability assessment of blood-brain barrier., PMID:29100486
[The Endothelin ETB Receptor Antagonist BQ788 Protects against Brain Edema after Fluid Percussion Injury by Decreasing Vascular Endothelial Growth Factor-A Expression in Mice]., PMID:28966265
Claudin-5-Binders Enhance Permeation of Solutes across the Blood-Brain Barrier in a Mammalian Model., PMID:28819070
New thrombolytic strategy providing neuroprotection in experimental ischemic stroke: MMP10 alone or in combination with tissue-type plasminogen activator., PMID:28379489
Chronic depletion of gonadal testosterone leads to blood-brain barrier dysfunction and inflammation in male mice., PMID:28256950
TGFβ1 exacerbates blood-brain barrier permeability in a mouse model of hepatic encephalopathy via upregulation of MMP9 and downregulation of claudin-5., PMID:26006017
Claudin-5 levels are reduced from multiple cell types in human failing hearts and are associated with mislocalization of ephrin-B1., PMID:25440958
Vascular changes in the developing rat retina in response to hypoxia., PMID:25433125
Interleukin-18 has antipermeablity and antiangiogenic activities in the eye: reciprocal suppression with VEGF., PMID:24515951
Autocrine MMP-2/9 secretion increases the BBB permeability in neuromyelitis optica., PMID:24259591
Claudin-5 controls intercellular barriers of human dermal microvascular but not human umbilical vein endothelial cells., PMID:23288152
Novel 3D analysis of Claudin-5 reveals significant endothelial heterogeneity among CNS microvessels., PMID:23261753
Early brain injury alters the blood-brain barrier phenotype in parallel with β-amyloid and cognitive changes in adulthood., PMID:23149553
Influenza infects lung microvascular endothelium leading to microvascular leak: role of apoptosis and claudin-5., PMID:23115643
Matrix metalloproteinase-2-mediated occludin degradation and caveolin-1-mediated claudin-5 redistribution contribute to blood-brain barrier damage in early ischemic stroke stage., PMID:22378877
Lipopolysaccharide-enhanced transcellular transport of HIV-1 across the blood-brain barrier is mediated by luminal microvessel IL-6 and GM-CSF., PMID:22129063
Pericyte-derived glial cell line-derived neurotrophic factor increase the expression of claudin-5 in the blood-brain barrier and the blood-nerve barrier., PMID:22002662
Claudin-5 as an immunohistochemical marker for angiosarcoma and hemangioendotheliomas., PMID:21959309
Matrix metalloproteinase-2 and -9 secreted by leukemic cells increase the permeability of blood-brain barrier by disrupting tight junction proteins., PMID:21857898
Interendothelial claudin-5 expression depends on cerebral endothelial cell-matrix adhesion by β(1)-integrins., PMID:21772312
Tight junction proteins expression and modulation in immune cells and multiple sclerosis., PMID:21762372
MMP-mediated disruption of claudin-5 in the blood-brain barrier of rat brain after cerebral ischemia., PMID:21717368
Tracing the endocytosis of claudin-5 in brain endothelial cells., PMID:21717366
Characterization and evaluation of the antitumour activity of a dual-targeting monoclonal antibody against claudin-3 and claudin-4., PMID:21115905
Role of ATP synthase alpha subunit in low-dose endothelial monocyte-activating polypeptide-II-induced opening of the blood-tumor barrier., PMID:21035144
Golgi-associated cPLA2alpha regulates endothelial cell-cell junction integrity by controlling the trafficking of transmembrane junction proteins., PMID:19675210
Thrombin induces rapid disassembly of claudin-5 from the tight junction of endothelial cells., PMID:19665016
Derangements in endothelial cell-to-cell junctions involved in the pathogenesis of hypercholesterolemia-induced erectile dysfunction., PMID:19453913
Expression of Claudin-1, Claudin-3 and Claudin-5 in human blood-brain barrier mimicking cell line ECV304 is inducible by glioma-conditioned media., PMID:18817843
Protecting against cerebrovascular injury: contributions of 12/15-lipoxygenase to edema formation after transient focal ischemia., PMID:18635843
RNAi-mediated reversible opening of the blood-brain barrier., PMID:18509865
Endothelial cell barrier impairment induced by glioblastomas and transforming growth factor beta2 involves matrix metalloproteinases and tight junction proteins., PMID:18431253
Phosphorylation of claudin-5 and occludin by rho kinase in brain endothelial cells., PMID:18187566
SOX-18 controls endothelial-specific claudin-5 gene expression and barrier function., PMID:18065521
Role of TNF-alpha in lung tight junction alteration in mouse model of acute lung inflammation., PMID:17971210
For research use only. Not for human or drug use.
