Discovery and Characterization of a First-in-Class LIV1-TLR7/8 Immunomodulatory Conjugate with Robust Myeloid Activation and Antitumor Activity., PMID:40411528
Cyclophilin-CD147 interaction enables SARS-CoV-2 infection of human monocytes and their activation via Toll-like receptors 7 and 8., PMID:39963132
Immune complexes-mediated activation of neutrophils in systemic lupus erythematosus is dependent on RNA recognition by toll-like receptor 8., PMID:39776899
TLR7/8 Activation in Immune Cells and Muscle by RNA-Containing Immune Complexes: Role in Inflammation and the Pathogenesis of Myositis., PMID:39279150
Design and Optimization of Selectivity-Tunable Toll-like Receptor 7/8 Agonists as Novel Antibody-Drug Conjugate Payloads., PMID:39172064
Antiphospholipid-exposed trophoblast-derived extracellular vesicles express elevated levels of TLR7/8-activating microRNAs and induce endometrial endothelial activation, in part, through TLR7., PMID:38797133
TLR8 agonist selgantolimod regulates Kupffer cell differentiation status and impairs HBV entry into hepatocytes via an IL-6-dependent mechanism., PMID:38697771
MiR-574-5p activates human TLR8 to promote autoimmune signaling and lupus., PMID:38589923
A molecular atlas of innate immunity to adjuvanted and live attenuated vaccines, in mice., PMID:35087093
Immune Modulating Antibody-Drug Conjugate (IM-ADC) for Cancer Immunotherapy., PMID:34730979
Self-assembly nanovaccine containing TLR7/8 agonist and STAT3 inhibitor enhances tumor immunotherapy by augmenting tumor-specific immune response., PMID:34452929
Novel TLR 7/8 agonists for improving NK cell mediated antibody-dependent cellular cytotoxicity (ADCC)., PMID:33558639
The anti-tumor effects of cetuximab in combination with VTX-2337 are T cell dependent., PMID:33452311
Novel Lipidated Imidazoquinoline TLR7/8 Adjuvants Elicit Influenza-Specific Th1 Immune Responses and Protect Against Heterologous H3N2 Influenza Challenge in Mice., PMID:32210973
In vivo cancer vaccination: Which dendritic cells to target and how?, PMID:30390423
CLEC10A Is a Specific Marker for Human CD1c+ Dendritic Cells and Enhances Their Toll-Like Receptor 7/8-Induced Cytokine Secretion., PMID:29755453
Recognition of microbial viability via TLR8 drives TFH cell differentiation and vaccine responses., PMID:29556002
TLR8 ligation induces apoptosis of monocytic myeloid-derived suppressor cells., PMID:29345064
TLR8 combined withTLR3 or TLR4 agonists enhances DC-NK driven effector Tc1 cells., PMID:29103998
Phase Ib Study of Immune Biomarker Modulation with Neoadjuvant Cetuximab and TLR8 Stimulation in Head and Neck Cancer to Overcome Suppressive Myeloid Signals., PMID:29061643
BAFF augments IgA2 and IL-10 production by TLR7/8 stimulated total peripheral blood B cells., PMID:28921509
TLR7/8 adjuvant overcomes newborn hyporesponsiveness to pneumococcal conjugate vaccine at birth., PMID:28352660
Impaired expression and function of TLR8 in chronic HBV infection and its association with treatment responses during peg-IFN-α-2a antiviral therapy., PMID:28236535
Phase Ib Trial of the Toll-like Receptor 8 Agonist, Motolimod (VTX-2337), Combined with Cetuximab in Patients with Recurrent or Metastatic SCCHN., PMID:27810904
Infants with low vaccine antibody responses have altered innate cytokine response., PMID:27745950
Thermoresponsive Polymer Nanoparticles Co-deliver RSV F Trimers with a TLR-7/8 Adjuvant., PMID:27583777
Characterization of TLR-induced inflammatory responses in COPD and control lung tissue explants., PMID:27729782
Kidney Expression of Toll Like Receptors in Lupus Nephritis: Quantification and Clinicopathological Correlations., PMID:27635115
HCV RNA Activates APCs via TLR7/TLR8 While Virus Selectively Stimulates Macrophages Without Inducing Antiviral Responses., PMID:27385120
Evaluation of EBV transformation of human memory B-cells isolated by FACS and MACS techniques., PMID:27043044
Toll-like Receptor 4 Ligands Down-regulate Fcγ Receptor IIb (FcγRIIb) via MARCH3 Protein-mediated Ubiquitination., PMID:26694610
Toll-like receptor 3 expression and function in childhood idiopathic nephrotic syndrome., PMID:26123900
TNF-α Induced by Hepatitis C Virus via TLR7 and TLR8 in Hepatocytes Supports Interferon Signaling via an Autocrine Mechanism., PMID:26023919
Granzyme B expression is enhanced in human monocytes by TLR8 agonists and contributes to antibody-dependent cellular cytotoxicity., PMID:25667415
Radiotherapy combined with TLR7/8 activation induces strong immune responses against gastrointestinal tumors., PMID:25609199
Differential expression of Toll-like receptors 7 & 8 mRNA in monocytes of patients with chronic hepatitis C infection: correlation with interferon and ribavirin treatment., PMID:25204046
The Split Virus Influenza Vaccine rapidly activates immune cells through Fcγ receptors., PMID:25203448
HIV-derived ssRNA binds to TLR8 to induce inflammation-driven macrophage foam cell formation., PMID:25090652
IL-21 enhances the activity of the TLR-MyD88-STAT3 pathway but not the classical TLR-MyD88-NF-κB pathway in human B cells to boost antibody production., PMID:24043893
TLR8 stimulation enhances cetuximab-mediated natural killer cell lysis of head and neck cancer cells and dendritic cell cross-priming of EGFR-specific CD8+ T cells., PMID:23685782
TLR7/8 agonists trigger immunostimulatory properties of human 6-sulfo LacNAc dendritic cells., PMID:23402811
Polymorphisms in key innate immune genes and their effects on measles vaccine responses and vaccine failure in children from Mozambique., PMID:22871352
VTX-2337 is a novel TLR8 agonist that activates NK cells and augments ADCC., PMID:22128302
Antiphospholipid antibodies induce translocation of TLR7 and TLR8 to the endosome in human monocytes and plasmacytoid dendritic cells., PMID:21734241
Expression of Toll-like receptors by neonatal leukocytes., PMID:21054549
Ro60-associated single-stranded RNA links inflammation with fetal cardiac fibrosis via ligation of TLRs: a novel pathway to autoimmune-associated heart block., PMID:20089705
Concomitant activation of P2Y(2) and P2Y(6) receptors on monocytes is required for TLR1/2-induced neutrophil migration by regulating IL-8 secretion., PMID:19735076
Self-RNA-antimicrobial peptide complexes activate human dendritic cells through TLR7 and TLR8., PMID:19703986
Human antiphospholipid antibodies induce TNFalpha in monocytes via Toll-like receptor 8., PMID:19457574
TLR7 and TLR8 ligands and antiphospholipid antibodies show synergistic effects on the induction of IL-1beta and caspase-1 in monocytes and dendritic cells., PMID:19249118
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