Catalog No.
RHN07701
Species reactivity
Human
Host species
Mouse
Isotype
IgG2a, kappa
Clonality
Monoclonal
Target
TMEM106B, Transmembrane protein 106B
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q9NUM4
Applications
ELISA
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
SAA1912
Myristoylation of TMEM106B by NMT1/2 regulates TMEM106B trafficking and turnover., PMID:40451428
Tracing TMEM106B fibril deposition in aging and Parkinson's disease with dementia brains., PMID:39872397
Host cell lectins ASGR1 and DC-SIGN jointly with TMEM106B confer ACE2 independence and imdevimab resistance to SARS-CoV-2 pseudovirus with spike mutation E484D., PMID:39791910
Physiological shedding and C-terminal proteolytic processing of TMEM106B., PMID:39709600
TMEM106B amyloid filaments in the Biondi bodies of ependymal cells., PMID:39503754
Cleaved TMEM106B forms amyloid aggregates in central and peripheral nervous systems., PMID:38886865
TMEM106B core deposition associates with TDP-43 pathology and is increased in risk SNP carriers for frontotemporal dementia., PMID:38232138
Novel Omicron Variants Enhance Anchored Recognition of TMEM106B: A New Pathway for SARS-CoV-2 Cellular Invasion., PMID:38206837
Molecular fragment characteristics and distribution of tangle associated TDP-43 (TATs) and other TDP-43 lesions in Alzheimer's disease., PMID:38093787
Antibody-recognizing residues 188-211 of TMEM106B exhibit immunohistochemical reactivity with the TMEM106B C-terminal fragment., PMID:37937069
The identification of high-performing antibodies for transmembrane protein 106B (TMEM106B) for use in Western blot, immunoprecipitation, and immunofluorescence., PMID:37545650
TMEM106B Fibrils from FTLD Patients and Healthy Controls., PMID:37530644
TMEM106B is a receptor mediating ACE2-independent SARS-CoV-2 cell entry., PMID:37421949
C-terminal TMEM106B fragments in human brain correlate with disease-associated TMEM106B haplotypes., PMID:37100087
Accumulation of TMEM106B C-terminal fragments in neurodegenerative disease and aging., PMID:36527486
Age-dependent formation of TMEM106B amyloid filaments in human brains., PMID:35344985
Intracellular Proteolysis of Progranulin Generates Stable, Lysosomal Granulins that Are Haploinsufficient in Patients with Frontotemporal Dementia Caused by GRN Mutations., PMID:28828399
Brain distribution of dipeptide repeat proteins in frontotemporal lobar degeneration and motor neurone disease associated with expansions in C9ORF72., PMID:24950788
TMEM106B p.T185S regulates TMEM106B protein levels: implications for frontotemporal dementia., PMID:23742080
For research use only. Not for human or drug use.
