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Anti-Human GJB2 Antibody (SAA1838)

Catalog #:   RHD81201 Specific References (50) DATASHEET
Host species: Mouse
Isotype: IgG2a, kappa
Applications: ELISA
Accession: P29033
Overview

Catalog No.

RHD81201

Species reactivity

Human

Host species

Mouse

Isotype

IgG2a, kappa

Clonality

Monoclonal

Target

Connexin-26, Cx26, GJB2, Gap junction beta-2 protein

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P29033

Applications

ELISA

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

SAA1838

Data Image
References

GJB2 Promotes HCC Progression by Activating Glycolysis Through Cytoplasmic Translocation and Generating a Suppressive Tumor Microenvironment Based on Single Cell RNA Sequencing., PMID:39162005

IgM Deficiency Associated With Connexin Mutation in an 18-Year-old Male., PMID:36968253

Antibody gene transfer treatment drastically improves epidermal pathology in a keratitis ichthyosis deafness syndrome model using male mice., PMID:36736132

Unusual cutaneous manifestations and congenital hearing loss in a patient with GJB2 (F142L) mutation., PMID:33914937

Vitamin D receptor and metabolite effects on corneal epithelial cell gap junction proteins., PMID:31465769

Roles of aberrant hemichannel activities due to mutant connexin26 in the pathogenesis of KID syndrome., PMID:30150638

Depolarized Hepatocytes Express the Stem/Progenitor Cell Marker Neighbor of Punc E11 After Bile Duct Ligation in Mice., PMID:29624127

Hidradenitis suppurativa in association with keratitis-ichthyosis-deafness syndrome treated with adalimumab., PMID:29570225

A deafness mechanism of digenic Cx26 (GJB2) and Cx30 (GJB6) mutations: Reduction of endocochlear potential by impairment of heterogeneous gap junctional function in the cochlear lateral wall., PMID:28823936

The Complex Structure of the Mouse Placental Labyrinth Revealed by Double Immunofluorescence Labeling of Slc2a1 and Gjb2., PMID:28724843

Deformation of the Outer Hair Cells and the Accumulation of Caveolin-2 in Connexin 26 Deficient Mice., PMID:26492081

Cx26 knockout predisposes the mammary gland to primary mammary tumors in a DMBA-induced mouse model of breast cancer., PMID:26439696

Anti-angiogenesis therapy and gap junction inhibition reduce MDA-MB-231 breast cancer cell invasion and metastasis in vitro and in vivo., PMID:26218768

A Convenient and Efficient Method to Enrich and Maintain Highly Proliferative Human Fetal Liver Stem Cells., PMID:25556695

Connexin26 (GJB2) deficiency reduces active cochlear amplification leading to late-onset hearing loss., PMID:25451287

Visfatin reduces gap junction mediated cell-to-cell communication in proximal tubule-derived epithelial cells., PMID:24335170

Ultrastructural pathological changes in the cochlear cells of connexin 26 conditional knockout mice., PMID:23917463

Importance of Connexin-43 based gap junction in cirrhosis and acute-on-chronic liver failure., PMID:23376361

Melanocytic tumors express connexin 43 but not 26: immunohistochemical analysis with potential significance in melanocytic oncogenesis., PMID:23344009

Connexin 36 is expressed in beta and connexins 26 and 32 in acinar cells at the end of the secondary transition of mouse pancreatic development and increase during fetal and perinatal life., PMID:22505190

Paris polyphylla Smith extract induces apoptosis and activates cancer suppressor gene connexin26 expression., PMID:22502669

Ablation of connexin30 in transgenic mice alters expression patterns of connexin26 and connexin32 in glial cells and leptomeninges., PMID:22098503

Connexin26 expression in brain parenchymal cells demonstrated by targeted connexin ablation in transgenic mice., PMID:21714813

Different domains are critical for oligomerization compatibility of different connexins., PMID:21348854

The human deafness-associated connexin 30 T5M mutation causes mild hearing loss and reduces biochemical coupling among cochlear non-sensory cells in knock-in mice., PMID:20858605

Clinical significance of the expression of connexin26 in colorectal cancer., PMID:20565955

The potency of the fs260 connexin43 mutant to impair keratinocyte differentiation is distinct from other disease-linked connexin43 mutants., PMID:20515445

Unique expression of connexins in the human cochlea., PMID:19450429

Clinical and molecular genetic analysis of a family with macrothrombocytopenia and early onset sensorineural hearing loss., PMID:19285578

Differential expression and localization of connexins 26 and 43 in the rat gingival epithelium., PMID:19194037

Perturbing plasma membrane hemichannels attenuates calcium signalling in cardiac cells and HeLa cells expressing connexins., PMID:18951659

Cellular characterization of Connexin26 and Connnexin30 expression in the cochlear lateral wall., PMID:18581144

Extracellular-loop peptide antibodies reveal a predominant hemichannel organization of connexins in polarized intestinal cells., PMID:18267319

The protective effect of functional connexin43 channels on a human epithelial cell line exposed to oxidative stress., PMID:18235030

Tissue microarray analysis of connexin expression and its prognostic significance in human breast cancer., PMID:17583422

A deafness-associated mutant human connexin 26 improves the epithelial barrier in vitro., PMID:17581693

A case of keratitis-ichthyosis-deafness (KID) syndrome., PMID:17442083

Connexin26 expression is associated with lymphatic vessel invasion and poor prognosis in human breast cancer., PMID:17203385

Connexins act as tumor suppressors in three-dimensional mammary cell organoids by regulating differentiation and angiogenesis., PMID:17047050

Differential induction of connexins 26 and 30 in skin tumors and their adjacent epidermis., PMID:16046668

Alterations in connexin26 expression during colorectal carcinogenesis., PMID:16015037

In vivo and in vitro expression of connexins in the human corneal epithelium., PMID:15914609

Connexin 26 correlates with Bcl-xL and Bax proteins expression in colorectal cancer., PMID:15770735

Expression of connexins 26, 32 and 43 in the human colon--an immunohistochemical study., PMID:15704645

Expression of connexin 26 in the lateral wall of the rat cochlea after acoustic trauma., PMID:15224875

Connexin47, connexin29 and connexin32 co-expression in oligodendrocytes and Cx47 association with zonula occludens-1 (ZO-1) in mouse brain., PMID:15183511

Connexins 26, 30, and 43: differences among spontaneous, chronic, and accelerated human wound healing., PMID:15140236

Gap junction development in the human fetal hair follicle and bulge region., PMID:15030324

Transport and function of cx26 mutants involved in skin and deafness disorders., PMID:14681041

The inner ear contains heteromeric channels composed of cx26 and cx30 and deafness-related mutations in cx26 have a dominant negative effect on cx30., PMID:14681039

Datasheet
$ 328
Product specifications
100 μg 328 1 mg 1640

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Anti-Human GJB2 Antibody (SAA1838) [RHD81201]
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