Catalog No.
RHE10601
Species reactivity
Human
Host species
Mouse
Isotype
IgG2a, kappa
Clonality
Monoclonal
Target
PTGER2, Prostaglandin E2 receptor EP4 subtype, PTGER4, PGE receptor EP4 subtype, Prostanoid EP4 receptor, PGE2 receptor EP4 subtype
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P35408
Applications
ELISA
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
SAA1812
The Prostaglandin EP4 Antagonist Vorbipiprant Combined with PD-1 Blockade for Refractory Microsatellite-Stable Metastatic Colorectal Cancer: A Phase Ib/IIa Trial., PMID:39620921
Blockade of EP4 by ASP7657 Modulates Myeloid Cell Differentiation In Vivo and Enhances the Antitumor Effect of Radiotherapy., PMID:38058393
Single-Cell Analysis Reveals EP4 as a Target for Restoring T-Cell Infiltration and Sensitizing Prostate Cancer to Immunotherapy., PMID:34740924
Ligand binding to human prostaglandin E receptor EP4 at the lipid-bilayer interface., PMID:30510193
Role of S1P/S1PR3 axis in release of CCL20 from human bronchial epithelial cells., PMID:30192865
Genomic and transcriptomic comparison of allergen and silver nanoparticle-induced mast cell degranulation reveals novel non-immunoglobulin E mediated mechanisms., PMID:29566008
Prostaglandin E2 Activates YAP and a Positive-Signaling Loop to Promote Colon Regeneration After Colitis but Also Carcinogenesis in Mice., PMID:27864128
Prostaglandin E2-EP4 signaling persistently amplifies CD40-mediated induction of IL-23 p19 expression through canonical and non-canonical NF-κB pathways., PMID:26189370
Autocrine and paracrine mechanisms of prostaglandin E₂ action on trophoblast/conceptus cells through the prostaglandin E₂ receptor (PTGER2) during implantation., PMID:23861370
Fluid flow shear stress upregulates prostanoid receptor EP2 but not EP4 in murine podocytes., PMID:23262148
Prostaglandin E2-prostaglandin E receptor subtype 4 (EP4) signaling mediates UV irradiation-induced systemic immunosuppression., PMID:21460251
A novel antagonist of the prostaglandin E(2) EP(4) receptor inhibits Th1 differentiation and Th17 expansion and is orally active in arthritis models., PMID:20423341
Proneoplastic effects of PGE2 mediated by EP4 receptor in colorectal cancer., PMID:19558693
MF498 [N-{[4-(5,9-Diethoxy-6-oxo-6,8-dihydro-7H-pyrrolo[3,4-g]quinolin-7-yl)-3-methylbenzyl]sulfonyl}-2-(2-methoxyphenyl)acetamide], a selective E prostanoid receptor 4 antagonist, relieves joint inflammation and pain in rodent models of rheumatoid and osteoarthritis., PMID:18287210
8-iso-PGE2 stimulates anion efflux from airway epithelial cells via the EP4 prostanoid receptor., PMID:17690331
Extracellular matrix fibronectin increases prostaglandin E2 receptor subtype EP4 in lung carcinoma cells through multiple signaling pathways: the role of AP-2., PMID:17237224
Protective effect of prostaglandin EP4-receptor agonist on anti-glomerular basement membrane antibody-associated nephritis., PMID:17031072
Prostacyclin-IP signaling and prostaglandin E2-EP2/EP4 signaling both mediate joint inflammation in mouse collagen-induced arthritis., PMID:16446378
A novel prostaglandin E receptor 4-associated protein participates in antiinflammatory signaling., PMID:16424369
Role of prostaglandin E2 receptor subtypes in ovarian follicle growth in the rat in vivo. Correlation with interleukin-8 and neutrophils., PMID:15944932
Prostaglandin E2 receptor subtypes, EP1, EP2, EP3 and EP4 in human and mouse ocular tissues--a comparative immunohistochemical study., PMID:15380814
Activation of EP4 receptors contributes to prostaglandin E2-mediated stimulation of renal sensory nerves., PMID:15292051
Interleukin-1beta-induced mucin production in human airway epithelium is mediated by cyclooxygenase-2, prostaglandin E2 receptors, and cyclic AMP-protein kinase A signaling., PMID:15266025
The role of prostaglandin E2 receptors in the pathogenesis of rheumatoid arthritis., PMID:12208866
Expression and localization of FP and EP prostanoid receptor subtypes in human ocular tissues., PMID:11980863
Sequestration and phosphorylation of the prostaglandin E2 EP4 receptor: dependence on the C-terminal tail., PMID:11597569
Prostaglandin E(2) regulates the level and stability of cyclooxygenase-2 mRNA through activation of p38 mitogen-activated protein kinase in interleukin-1 beta-treated human synovial fibroblasts., PMID:11423555
Comparison of agonist-induced internalization of the human EP2 and EP4 prostaglandin receptors: role of the carboxyl terminus in EP4 receptor sequestration., PMID:11093764
Immunolocalization of the four prostaglandin E2 receptor proteins EP1, EP2, EP3, and EP4 in human kidney., PMID:10477136
A conserved threonine in the second extracellular loop of the human EP2 and EP4 receptors is required for ligand binding., PMID:9788776
For research use only. Not for human or drug use.
