Catalog No.
RHE71701
Species reactivity
Human
Host species
Mouse
Isotype
IgG2a, kappa
Clonality
Monoclonal
Target
PSEN2, PS-2, AD4, PS2, AD3LP, STM2, E5-1, STM-2, Presenilin-2, AD5, PSNL2
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P49810
Applications
ELISA
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
SAA1783
Multiple system atrophy with amyloid-β-predominant Alzheimer's disease neuropathologic change., PMID:38712319
Alzheimer's Disease: Models and Molecular Mechanisms Informing Disease and Treatments., PMID:38247923
Soluble TREM2 in CSF and its association with other biomarkers and cognition in autosomal-dominant Alzheimer's disease: a longitudinal observational study., PMID:35305339
Exercise Reverses Amyloid β-Peptide-Mediated Cognitive Deficits in Alzheimer's Disease Mice Expressing Mutant Presenilin-2., PMID:34816813
Unraveling the Gordian knot: genetics and the troubled road to effective therapeutics for Alzheimer's disease., PMID:34718566
Spatial patterns of neuroimaging biomarker change in individuals from families with autosomal dominant Alzheimer's disease: a longitudinal study., PMID:29397305
Reproductive and developmental toxicology studies with gantenerumab in PS2APP transgenic mice., PMID:28754630
Expression of the Alzheimer's Disease Mutations AβPP695sw and PSEN1M146I in Double-Transgenic Göttingen Minipigs., PMID:27540966
Characterization of Amyloid-β Deposits in Bovine Brains., PMID:26890772
Modeling Alzheimer's disease in mouse without mutant protein overexpression: cooperative and independent effects of Aβ and tau., PMID:24278307
CD147, a gamma-secretase associated protein is upregulated in Alzheimer's disease brain and its cellular trafficking is affected by presenilin-2., PMID:19751784
Estrogen-related receptor alpha1 transcriptional activities are regulated in part via the ErbB2/HER2 signaling pathway., PMID:17259347
Tamoxifen-induced ER-alpha-SRC-3 interaction in HER2 positive human breast cancer; a possible mechanism for ER isoform specific recurrence., PMID:17158759
Antibody-bound amyloid precursor protein upregulates ornithine decarboxylase expression., PMID:16469300
Trastuzumab therapy for tamoxifen-stimulated endometrial cancer., PMID:16166331
Presenilin immunoreactivity in Alzheimer's disease., PMID:16128871
A {gamma}-secretase-independent mechanism of signal transduction by the amyloid precursor protein., PMID:16103124
Neurogenetics II: complex disorders., PMID:15834017
Longer forms of amyloid beta protein: implications for the mechanism of intramembrane cleavage by gamma-secretase., PMID:15647487
Calcium binding sequences in calmyrin regulates interaction with presenilin-2., PMID:15475008
Expression of truncated presenilin 2 splice variant in Alzheimer's disease, bipolar disorder, and schizophrenia brain cortex., PMID:15306129
Partial loss of presenilins causes seborrheic keratosis and autoimmune disease in mice., PMID:15128703
Identification of neuronal plasma membrane microdomains that colocalize beta-amyloid and presenilin: implications for beta-amyloid precursor protein processing., PMID:12890502
Notch and the amyloid precursor protein are cleaved by similar gamma-secretase(s)., PMID:12515548
No endogenous A beta production in presenilin-deficient fibroblasts., PMID:12105423
Inflammation, apoptosis, and Alzheimer's disease., PMID:12061507
Alterations in behavior, amyloid beta-42, caspase-3, and Cox-2 in mutant PS2 transgenic mouse model of Alzheimer's disease., PMID:12039862
Endoplasmic reticulum stress-inducible protein, Herp, enhances presenilin-mediated generation of amyloid beta-protein., PMID:11799129
Aspartyl protease inhibitor pepstatin binds to the presenilins of Alzheimer's disease., PMID:11444983
Evolution of distinct expression patterns for engrailed paralogues in higher crustaceans (Malacostraca)., PMID:11180798
Brain expression of presenilins in sporadic and early-onset, familial Alzheimer's disease., PMID:11126202
Presenilin 2 mutation does not influence expression and concentration of APP forms in human platelets., PMID:11126197
Identification of ubiquilin, a novel presenilin interactor that increases presenilin protein accumulation., PMID:11076969
Presenilin 2 expression in neuronal cells: induction during differentiation of embryonic carcinoma cells., PMID:10694435
Glial expression of presenilin epitopes in human brain with cerebral infarction and in astrocytoma., PMID:10502036
A myristoylated calcium-binding protein that preferentially interacts with the Alzheimer's disease presenilin 2 protein., PMID:10366599
Analysis of presenilin 1 and presenilin 2 expression and processing by newly developed monoclonal antibodies., PMID:10340748
Impaired proteolytic processing of presenilin-1 in chromosome 14-linked familial Alzheimer's disease patient lymphocytes., PMID:10025714
Reactions from rat gastric mucosa during one year of Helicobacter pylori infection., PMID:9952232
Interaction of presenilins with the filamin family of actin-binding proteins., PMID:9437013
On the spurious endoproteolytic processing of the presenilin proteins in cultured cells and tissues., PMID:9391147
The seven-transmembrane spanning topography of the Alzheimer disease-related presenilin proteins in the plasma membranes of cultured cells., PMID:9391146
Cellular expression and proteolytic processing of presenilin proteins is developmentally regulated during neuronal differentiation., PMID:9375676
Autosomal dominant dementia with widespread neurofibrillary tangles., PMID:9382467
Alzheimer presenilins in the nuclear membrane, interphase kinetochores, and centrosomes suggest a role in chromosome segregation., PMID:9298903
Neuronal expression and intracellular localization of presenilins in normal and Alzheimer disease brains., PMID:9291942
Cell surface expression of the Alzheimer disease-related presenilin proteins., PMID:9275228
Interaction between amyloid precursor protein and presenilins in mammalian cells: implications for the pathogenesis of Alzheimer disease., PMID:9223340
Immunohistochemical analysis of presenilin 2 expression in the mouse brain: distribution pattern and co-localization with presenilin 1 protein., PMID:9203550
Presenilin proteins undergo heterogeneous endoproteolysis between Thr291 and Ala299 and occur as stable N- and C-terminal fragments in normal and Alzheimer brain tissue., PMID:9173929
For research use only. Not for human or drug use.
