Catalog No.
RHC25301
Species reactivity
Human
Host species
Mouse
Isotype
IgG2a, lambda
Clonality
Monoclonal
Target
CPSD, CTSD, Cathepsin D
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P07339
Applications
ELISA
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
SAA1766
Antibodies against the multifaceted cathepsin D protein open new avenues for TNBC immunotherapy., PMID:39800383
Terminal Complement Activation Is Induced by Factors Released from Endplate Tissue of Disc Degeneration Patients and Stimulates Expression of Catabolic Enzymes in Annulus Fibrosus Cells., PMID:36980228
LAMP3 inhibits autophagy and contributes to cell death by lysosomal membrane permeabilization., PMID:34802379
The c.863A>G (p.Glu288Gly) variant of the CTSD gene is not associated with CLN10 disease., PMID:34331747
LRRK2 is required for CD38-mediated NAADP-Ca2+ signaling and the downstream activation of TFEB (transcription factor EB) in immune cells., PMID:34313548
Overexpression of Lipocalin-2 Inhibits Proliferation and Invasiveness of Human Glioblastoma Multiforme Cells by Activating ERK Targeting Cathepsin D Expression., PMID:34062746
A 9-kDa matricellular SPARC fragment released by cathepsin D exhibits pro-tumor activity in the triple-negative breast cancer microenvironment., PMID:33995652
CREG1 promotes lysosomal biogenesis and function., PMID:33966596
Trehalose causes low-grade lysosomal stress to activate TFEB and the autophagy-lysosome biogenesis response., PMID:33706671
Immunoproteomics approach revealed elevated autoantibody levels against ANXA1 in early stage gallbladder carcinoma., PMID:33261560
Pyrroloquinoline quinine ameliorates doxorubicin-induced autophagy-dependent apoptosis via lysosomal-mitochondrial axis in vascular endothelial cells., PMID:31226464
Anxa2- and Ctsd-knockout CHO cell lines to diminish the risk of contamination with host cell proteins., PMID:30972970
Lack of Cathepsin D in the Renal Proximal Tubular Cells Resulted in Increased Sensitivity against Renal Ischemia/Reperfusion Injury., PMID:30959855
Investigation of cathepsin D-mAb interactions using a combined experimental and computational tool set., PMID:30882893
Immunotherapy of triple-negative breast cancer with cathepsin D-targeting antibodies., PMID:30717773
Lysosomes, autophagosomes and Alzheimer pathology in dementia with Lewy body disease., PMID:29748975
Histochemical characteristics of regressing vessels in the hyaloid vascular system of neonatal mice: Novel implication for vascular atrophy., PMID:29596849
High-mobility group box 1 is an important mediator of microglial activation induced by cortical spreading depression., PMID:27142867
Altered lysosomal proteins in neural-derived plasma exosomes in preclinical Alzheimer disease., PMID:26062630
Blood mRNA expression profiling predicts survival in patients treated with tremelimumab., PMID:24721645
Olfactory deficits in Niemann-Pick type C1 (NPC1) disease., PMID:24391715
Apoptosis-related proteins are potential markers of neonatal hypoxic-ischemic encephalopathy (HIE) injury., PMID:24269372
Cathepsin D stimulates the activities of secreted plasminogen activators in the breast cancer acidic environment., PMID:24026424
Immunohistochemical analysis of macroautophagy: recommendations and limitations., PMID:23242143
Localization of cathepsin D in mouse reproductive tissues and its acquisition onto sperm surface during epididymal sperm maturation., PMID:23177142
The immunohematologic and patient safety benefits of a centralized transfusion database., PMID:22803792
Activation and alteration of lysosomes in multiple system atrophy., PMID:22343695
Roles of αvβ5, FAK and MerTK in oxidative stress inhibition of RPE cell phagocytosis., PMID:22138557
Autophagy activation in the injured photoreceptor inhibits fas-mediated apoptosis., PMID:21421874
The role of autophagy emerging in postinfarction cardiac remodelling., PMID:21406597
Serum autoantibody profiling using a natural glycoprotein microarray for the prognosis of early melanoma., PMID:20879797
Anti-p53 antibodies in serum: relationship to tumor biology and prognosis of breast cancer patients., PMID:19763913