Catalog No.
RHE59001
Species reactivity
Human
Host species
Mouse
Isotype
IgG2a, kappa
Clonality
Monoclonal
Target
Interferon alpha binding protein, Interferon alpha/beta receptor 2, IFNAR2, IFN-alpha binding protein, IFN-R-2, IFNABR, IFNARB, Type I interferon receptor 2, IFN-alpha/beta receptor 2
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P48551
Applications
ELISA
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
SAA1733
Intestinal mucosal transcriptomic responses of Asian seabass (Lates calcarifer) vaccinated with an oral hydrogel-encapsulated multivalent Vibrio antigen following Vibrio spp. infection., PMID:40252617
Type I interferon autoantibody footprints reveal neutralizing mechanisms and allow inhibitory decoy design., PMID:40111224
A sensitive assay for measuring whole-blood responses to type I IFNs., PMID:39312669
Structural basis for the recognition of IFNAR1 by the humanized therapeutic monoclonal antibody QX006N for the treatment of systemic lupus erythematosus., PMID:38649079
Rickettsia rickettsii virulence determinants RARP2 and RapL mitigate IFN-β signaling in primary human dermal microvascular endothelial cells., PMID:38445878
Differential expression of Type I interferon and inflammatory genes in SARS-CoV-2-infected patients treated with monoclonal antibodies., PMID:37904704
Severity of SARS-CoV-2 infection in children with inborn errors of immunity (primary immunodeficiencies): a systematic review., PMID:37559153
A natural goldmine of binding proteins and soluble receptors simplified their translation to blockbuster drugs, all in one decade., PMID:36875111
Rubella Virus Triggers Type I Interferon Antiviral Response in Cultured Human Neural Cells: Involvement in the Control of Viral Gene Expression and Infectious Progeny Production., PMID:36077193
Defining resistance and tolerance traits in Covid-19: towards a stratified medicine approach., PMID:35686910
Implicating effector genes at COVID-19 GWAS loci using promoter-focused Capture-C in disease-relevant immune cell types., PMID:35659055
Inflammasome activation in infected macrophages drives COVID-19 pathology., PMID:35483404
Auto-antibodies to type I IFNs can underlie adverse reactions to yellow fever live attenuated vaccine., PMID:33544838
Role of Host Immune and Inflammatory Responses in COVID-19 Cases with Underlying Primary Immunodeficiency: A Review., PMID:33337932
Lactobacillus rhamnosus GG alleviates β-conglycinin-induced allergy by regulating the T cell receptor signaling pathway., PMID:33185639
Acute activation of bronchopulmonary vagal nociceptors by type I interferons., PMID:32924209
Anifrolumab in systemic lupus erythematosus: current knowledge and future considerations., PMID:32237942
Identification of Interferon Receptor IFNAR2 As a Novel HCV Entry Factor by Using Chemical Probes., PMID:31972076
Trial of Anifrolumab in Active Systemic Lupus Erythematosus., PMID:31851795
Genetic Diversity of Collaborative Cross Mice Controls Viral Replication, Clinical Severity, and Brain Pathology Induced by Zika Virus Infection, Independently of Oas1b., PMID:31694939
Anti-interferon-α receptor 1 antibodies attenuate inflammation and organ injury following hemorrhagic shock., PMID:31009444
CRISPR/Cas9 knockout of USP18 enhances type I IFN responsiveness and restricts HIV-1 infection in macrophages., PMID:29437254
Type-I interferon signalling through IFNAR1 plays a deleterious role in the outcome after stroke., PMID:28647375
Soybean-derived Bowman-Birk Inhibitor (BBI) Inhibits HIV Replication in Macrophages., PMID:27734899
Decreased soluble IFN-β receptor (sIFNAR2) in multiple sclerosis patients: A potential serum diagnostic biomarker., PMID:27613121
Interferon Beta: From Molecular Level to Therapeutic Effects., PMID:27572132
The bovine endometrial epithelial cells promote the differentiation of trophoblast stem-like cells to binucleate trophoblast cells., PMID:27473847
Endothelial progenitor dysfunction associates with a type I interferon signature in primary antiphospholipid syndrome., PMID:27432357
Renal microRNA- and RNA-profiles in progressive chronic kidney disease., PMID:26707063
Development of Th17-Associated Interstitial Kidney Inflammation in Lupus-Prone Mice Lacking the Gene Encoding STAT-1., PMID:26636548
Cytokine Activation by Antibody Fragments Targeted to Cytokine-Receptor Signaling Complexes., PMID:26546677
Virus Multiplicity of Infection Affects Type I Interferon Subtype Induction Profiles and Interferon-Stimulated Genes., PMID:26355085
Structural basis of the broadly neutralizing anti-interferon-α antibody rontalizumab., PMID:26099203
A fully human monoclonal antibody with novel binding epitope and excellent neutralizing activity to multiple human IFN-α subtypes: A candidate therapy for systemic lupus erythematosus., PMID:26048268
TNF-α Induced by Hepatitis C Virus via TLR7 and TLR8 in Hepatocytes Supports Interferon Signaling via an Autocrine Mechanism., PMID:26023919
Structural Insights into the Neutralization Properties of the Fully Human, Anti-interferon Monoclonal Antibody Sifalimumab., PMID:25925951
Molecular basis for antagonistic activity of anifrolumab, an anti-interferon-α receptor 1 antibody., PMID:25606664
Development of an in vitro model for the analysis of bovine endometrium using simple techniques., PMID:25496024
Cumulus cell-expressed type I interferons induce cumulus expansion in mice., PMID:25429090
Production and characterization of thirteen human type-I interferon-α subtypes., PMID:25149396
Single-nucleotide polymorphism associations in common with immune responses to measles and rubella vaccines., PMID:25139337
Critical role of interferon-α constitutively produced in human hepatocytes in response to RNA virus infection., PMID:24587086
High efficiency cell-specific targeting of cytokine activity., PMID:24398568
Luteolin sensitizes the antiproliferative effect of interferon α/β by activation of Janus kinase/signal transducer and activator of transcription pathway signaling through protein kinase A-mediated inhibition of protein tyrosine phosphatase SHP-2 in cancer cells., PMID:24333668
Kinetic analysis of cytokine-mediated receptor assembly using engineered FC heterodimers., PMID:23703950
Expression of IFNAR2 mRNA in peripheral blood mononuclear cells of patients with HCV infection., PMID:22870788
Hepatitis B Virus Genotype B and High Expression of Interferon Alpha Receptor β Subunit are Associated With Better Response to Pegylated Interferon Alpha 2a in Chinese Patients With Chronic Hepatitis B Infection., PMID:22783345
Structural insights into a human anti-IFN antibody exerting therapeutic potential for systemic lupus erythematosus., PMID:22307521
LPS regulates SOCS2 transcription in a type I interferon dependent autocrine-paracrine loop., PMID:22291912
Interleukin-22: implications for liver ischemia-reperfusion injury., PMID:22262131
For research use only. Not for human or drug use.
