Catalog No.
RHJ75001
Species reactivity
Human
Host species
Mouse
Isotype
IgG2a, kappa
Clonality
Monoclonal
Target
Inhibitory receptor protein 60, IRp60, CMRF35-H, CLM-8, CMRF35-H9, CMRF35-like molecule 8, CD300A, NK inhibitory receptor, IgSF12, CD300a, CMRF35H, IRC1/IRC2, IGSF12, CD300 antigen-like family member A, CMRF-35-H9, Immunoglobulin superfamily member 12
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q9UGN4
Applications
ELISA
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
SAA1721
Transcriptomic profiling of severe and critical COVID-19 patients reveals alterations in expression, splicing and polyadenylation., PMID:40251257
A Humanized Monoclonal Antibody Against CD300A Ameliorates Acute Ischemic Stroke in Humanized Mice., PMID:39804190
A squalene oil emulsified MPL-A and anti-CD200/CD300a antibodies adjuvanted whole-killed Leishmania vaccine provides durable immunity against L. donovani parasites., PMID:39288578
Virus-driven dysregulation of the BCR pathway: a potential mechanism for the high prevalence of HIV related B-cell lymphoma., PMID:39196379
Blockade of CD300A enhances the ability of human NK cells to lyse hematologic malignancies., PMID:38425216
Development of Monoclonal Antibodies Specific to Either CD300AR111 or CD300AQ111 or Both., PMID:37902989
Adjuvantation of whole-killed Leishmania vaccine with anti-CD200 and anti-CD300a antibodies potentiates its efficacy and provides protection against wild-type parasites., PMID:37778149
Human IgMhiCD300a+ B Cells Are Circulating Marginal Zone Memory B Cells That Respond to Pneumococcal Polysaccharides and Their Frequency Is Decreased in People Living with HIV., PMID:37762055
CD300a Regulates Mouse Macrophage Functionality in Allergic Inflammation., PMID:36928079
Leishmania donovani induces CD300a expression to dampen effector properties of CD11c+ dendritic and antigen activated CD8+ T cells., PMID:36610528
Novel peanut-specific human IgE monoclonal antibodies enable screens for inhibitors of the effector phase in food allergy., PMID:36248809
Overexpression of FcεRI on Bone Marrow Mast Cells, but Not MRGPRX2, in Clonal Mast Cell Disorders With Wasp Venom Anaphylaxis., PMID:35281031
Cromolyn Sodium differentially regulates human mast cell and mouse leukocyte responses to control allergic inflammation., PMID:35278626
CD300a blockade enhances efferocytosis by infiltrating myeloid cells and ameliorates neuronal deficit after ischemic stroke., PMID:34652960
CD300a contributes to the resolution of articular inflammation triggered by MSU crystals by controlling neutrophil apoptosis., PMID:34002852
Direct Infection of B Cells by Dengue Virus Modulates B Cell Responses in a Cambodian Pediatric Cohort., PMID:33643283
CD300a inhibits CD16-mediated NK cell effector functions in HIV-1-infected patients., PMID:31467415
Autonomous regulation of IgE-mediated mast cell degranulation and immediate hypersensitivity reaction by an inhibitory receptor CD300a., PMID:31155312
The immunoreceptor CD300a controls the intensity of inflammation and dysfunction in a model of Ag-induced arthritis in mice., PMID:31107994
No difference in human mast cells derived from peanut allergic versus non-allergic subjects., PMID:29992767
CD300c costimulates IgE-mediated basophil activation, and its expression is increased in patients with cow's milk allergy., PMID:29906528
CD300c is uniquely expressed on CD56 bright Natural Killer Cells and differs from CD300a upon ligand recognition., PMID:27040328
The Phosphatidylserine and Phosphatidylethanolamine Receptor CD300a Binds Dengue Virus and Enhances Infection., PMID:26468529
Involvement of CD300a Phosphatidylserine Immunoreceptor in Aluminum Salt Adjuvant-Induced Th2 Responses., PMID:25911756
Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia., PMID:25799995
Chicken CD300a homolog is found on B lymphocytes, various leukocytes populations and binds to phospholipids., PMID:25681077
Mechanism of phosphatidylserine inhibition of IgE/FcεRI-dependent anaphylactic human basophil degranulation via CD300a., PMID:24815424
Transcriptional profiling of human monocytes identifies the inhibitory receptor CD300a as regulator of transendothelial migration., PMID:24058511
The interaction between CD300a and phosphatidylserine inhibits tumor cell killing by NK cells., PMID:23640773
CD300c is an activating receptor expressed on human monocytes., PMID:23571507
Human CD300C delivers an Fc receptor-γ-dependent activating signal in mast cells and monocytes and differs from CD300A in ligand recognition., PMID:23372157
The CD300 molecules: an emerging family of regulators of the immune system., PMID:23293083
Expressions and inhibitory functions of CD300a receptors on purified human basophils., PMID:23163658
Apoptotic cells suppress mast cell inflammatory responses via the CD300a immunoreceptor., PMID:22826299
Functional requirements for inhibitory signal transmission by the immunomodulatory receptor CD300a., PMID:22537350
Human CD300a binds to phosphatidylethanolamine and phosphatidylserine, and modulates the phagocytosis of dead cells., PMID:22302738
Identification of phosphatidylserine as a ligand for the CD300a immunoreceptor., PMID:22185693
CD300a is expressed on human basophils and seems to inhibit IgE/FcεRI-dependent anaphylactic degranulation., PMID:22173928
Differential expression of CD300a/c on human TH1 and TH17 cells., PMID:22046970
CD300a and CD300f differentially regulate the MyD88 and TRIF-mediated TLR signalling pathways through activation of SHP-1 and/or SHP-2 in human monocytic cell lines., PMID:22043923
CD300a is expressed on human B cells, modulates BCR-mediated signaling, and its expression is down-regulated in HIV infection., PMID:21482706
Expression and function of CD300 in NK cells., PMID:20656921
CD300a/c regulate type I interferon and TNF-alpha secretion by human plasmacytoid dendritic cells stimulated with TLR7 and TLR9 ligands., PMID:18535206
Suppression of normal and malignant kit signaling by a bispecific antibody linking kit with CD300a., PMID:18424727
Novel human CD4+ T lymphocyte subpopulations defined by CD300a/c molecule expression., PMID:17702825
Reversal of airway inflammation and remodeling in asthma by a bispecific antibody fragment linking CCR3 to CD300a., PMID:17088133
Mast cell costimulation by CD226/CD112 (DNAM-1/Nectin-2): a novel interface in the allergic process., PMID:16831868
Abrogation of allergic reactions by a bispecific antibody fragment linking IgE to CD300a., PMID:16750992
The inhibitory receptor IRp60 (CD300a) is expressed and functional on human mast cells., PMID:16339535
The inhibitory receptor IRp60 (CD300a) suppresses the effects of IL-5, GM-CSF, and eotaxin on human peripheral blood eosinophils., PMID:16254138
For research use only. Not for human or drug use.
