Catalog No.
RHH79401
Species reactivity
Human
Host species
Mouse
Isotype
IgG2a, kappa
Clonality
Monoclonal
Target
Cell adhesion molecule-related/down-regulated by oncogenes, CDO, CDON
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q4KMG0
Applications
ELISA
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
SAA1692
Inebilizumab-cdon: USFDA Approved for the Treatment of NMOSD (Neuromyelitis Optica Spectrum Disorder)., PMID:34011260
Cytoneme delivery of Sonic Hedgehog from ligand-producing cells requires Myosin 10 and a Dispatched-BOC/CDON co-receptor complex., PMID:33570491
The hedgehog co-receptor BOC differentially regulates SHH signaling during craniofacial development., PMID:33060130
Inebilizumab-cdon., PMID:32936251
Inebilizumab: First Approval., PMID:32729016
Ptch2/Gas1 and Ptch1/Boc differentially regulate Hedgehog signalling in murine primordial germ cell migration., PMID:32332736
Temporal and spatial expression patterns of Hedgehog receptors in the developing inner and middle ear., PMID:29139542
Fgfr2 is integral for bladder mesenchyme patterning and function., PMID:28052872
A novel function of TBK1 as a target of Cdon in oligodendrocyte differentiation and myelination., PMID:27797401
Distinct structural requirements for CDON and BOC in the promotion of Hedgehog signaling., PMID:25848697
Fgfr2 is integral for bladder mesenchyme patterning and function., PMID:25656370
Dosage-dependent regulation of pancreatic cancer growth and angiogenesis by hedgehog signaling., PMID:25310976
Ptch2 mediates the Shh response in Ptch1-/- cells., PMID:25085974
The osteoblast to osteocyte transition: epigenetic changes and response to the vitamin D3 hormone., PMID:24877565
Cdon and Boc: Two transmembrane proteins implicated in cell-cell communication., PMID:22326621
Boc and Gas1 each form distinct Shh receptor complexes with Ptch1 and are required for Shh-mediated cell proliferation., PMID:21664577
Overlapping roles and collective requirement for the coreceptors GAS1, CDO, and BOC in SHH pathway function., PMID:21664576
Boc modifies the holoprosencephaly spectrum of Cdo mutant mice., PMID:21183473
All mammalian Hedgehog proteins interact with cell adhesion molecule, down-regulated by oncogenes (CDO) and brother of CDO (BOC) in a conserved manner., PMID:20519495
Hedgehog pathway antagonist 5E1 binds hedgehog at the pseudo-active site., PMID:20504762
The mode of Hedgehog binding to Ihog homologues is not conserved across different phyla., PMID:18794898
Differential screening identifies transcripts with depot-dependent expression in white adipose tissues., PMID:18721461
The Hedgehog-binding proteins Gas1 and Cdo cooperate to positively regulate Shh signaling during mouse development., PMID:17504941
Boc is a receptor for sonic hedgehog in the guidance of commissural axons., PMID:17086203
Cortical thinning and hydrocephalus in mice lacking the immunoglobulin superfamily member CDO., PMID:16648472
The cell surface membrane proteins Cdo and Boc are components and targets of the Hedgehog signaling pathway and feedback network in mice., PMID:16647304
Close encounters: regulation of vertebrate skeletal myogenesis by cell-cell contact., PMID:15923648
Overexpression of the immunoglobulin superfamily members CDO and BOC enhances differentiation of the human rhabdomyosarcoma cell line RD., PMID:12720294
Expression of the boc gene during murine embryogenesis., PMID:11891987
BOC, an Ig superfamily member, associates with CDO to positively regulate myogenic differentiation., PMID:11782431
For research use only. Not for human or drug use.
