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Anti-Human MICB Antibody (SAA1687)

Catalog #:   RHH45101 Specific References (50) DATASHEET
Host species: Mouse
Isotype: IgG2a, kappa
Applications: ELISA
Accession: Q29980
Overview

Catalog No.

RHH45101

Species reactivity

Human

Host species

Mouse

Isotype

IgG2a, kappa

Clonality

Monoclonal

Target

MIC-B, MHC class I polypeptide-related sequence B, MICB, PERB11.2

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q29980

Applications

ELISA

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

SAA1687

Data Image
References

Unveiling the role of oxidative stress in ANCA-associated glomerulonephritis through integrated machine learning and bioinformatics analyses., PMID:40369957

Ophthalmological manifestations and plasma markers of inflammation in Ebola survivors in post-treatment era., PMID:40301432

CLN-619, a MICA/B monoclonal antibody that promotes innate immune cell-mediated antitumor activity., PMID:40274283

An epitope-directed mRNA vaccine inhibits tumor metastasis through the blockade of MICA/B α1/2 shedding., PMID:39999840

Detection and Quantification of Polymorphic MICA and MICB Molecules in Immunoassays: Initial Insights., PMID:39902633

Novel and potent MICA/B antibody is therapeutically effective in KRAS LKB1 mutant lung cancer models., PMID:39762078

Entry into the lytic cycle exposes EBV-infected cells to NK cell killing via upregulation of the MICB ligand for NKG2D and activation of the CD56bright and NKG2A+KIR+CD56dim subsets., PMID:39676862

[The effect of c-Myc on regulating the immune-related ligands in Y subtype small cell lung cancer through histone deacetylase 1]., PMID:39622733

Gene Expression Profiling of the Peritumoral Immune Cell Infiltrate of Penile Squamous Cell Carcinomas., PMID:39596210

Causal relationships between three plasma proteins and non-alcoholic fatty liver disease, mediated by Epstein-Barr virus EA-D antibody levels: a mendelian randomization study., PMID:39463412

A novel and potent MICA/B antibody is therapeutically effective in KRAS LKB1 mutant lung cancer models., PMID:39211152

Inhibition of MICA and MICB shedding enhances memory-like NK-cell-mediated cytotoxicity against multiple myeloma., PMID:39106432

Nanobody-based CAR NK cells for possible immunotherapy of MICA+ tumors., PMID:38756234

Tinostamustine (EDO-S101), an Alkylating Deacetylase Inhibitor, Enhances the Efficacy of Daratumumab in Multiple Myeloma by Upregulation of CD38 and NKG2D Ligands., PMID:38731936

Evasion of NKG2D-mediated cytotoxic immunity by sarbecoviruses., PMID:38653235

Efficacy of Pembrolizumab and Biomarker Analysis in Patients with WGS-Based Intermediate to High Tumor Mutational Load: Results from the Drug Rediscovery Protocol., PMID:38630551

A novel MICA/B-targeted chimeric antigen receptor augments the cytotoxicity of NK cells against tumor cells., PMID:38598902

MICA-specific nanobodies for diagnosis and immunotherapy of MICA+ tumors., PMID:38550583

Flow cytometry of DNMT1 as a biomarker of hypomethylating therapies., PMID:38345160

IL-17a-producing γδT cells and NKG2D signaling mediate bacterial endotoxin-induced neonatal lung injury: implications for bronchopulmonary dysplasia., PMID:37744375

[Construction of NKG2D CAR-NK92 cells and its killing effect on multiple myeloma cells]., PMID:37403715

A chimeric antigen receptor uniquely recognizing MICA/B stress proteins provides an effective approach to target solid tumors., PMID:37172578

Engaging natural killer cells for cancer therapy via NKG2D, CD16A and other receptors., PMID:37165468

A Phase I Trial of VEGF-A Inhibition Combined with PD-L1 Blockade for Recurrent Glioblastoma., PMID:36968223

A Phase 2b, Randomised, Double-blind, Placebo-controlled, Parallel-arm, Multicenter Study Evaluating the Safety and Efficacy of Tesnatilimab in Patients with Moderately to Severely Active Crohn's Disease., PMID:36939629

Circulating exosomal immuno-oncological checkpoints and cytokines are potential biomarkers to monitor tumor response to anti-PD-1/PD-L1 therapy in non-small cell lung cancer patients., PMID:36741391

The Latest Breakthroughs in Immunotherapy for Acute Myeloid Leukemia, with a Special Focus on NKG2D Ligands., PMID:36555547

Integrated analysis identifies the IL6/JAK/STAT signaling pathway and the estrogen response pathway associated with the pathogenesis of intracranial aneurysms., PMID:36451838

Targeting MICA/B with cytotoxic therapeutic antibodies leads to tumor control., PMID:35967081

A vaccine targeting resistant tumours by dual T cell plus NK cell attack., PMID:35614223

MICA/B-targeted antibody promotes NK cell-driven tumor immunity in patients with intrahepatic cholangiocarcinoma., PMID:35223192

Bispecific antibody-mediated redirection of NKG2D-CAR natural killer cells facilitates dual targeting and enhances antitumor activity., PMID:34599028

Leveraging NKG2D Ligands in Immuno-Oncology., PMID:34394116

MICA/B antibody induces macrophage-mediated immunity against acute myeloid leukemia., PMID:34359073

Establishment of HLA class I and MICA/B null HEK-293T panel expressing single MICA alleles to detect anti-MICA antibodies., PMID:34344955

Increased Concentrations of Circulating Soluble MHC Class I-Related Chain A (sMICA) and sMICB and Modulation of Plasma Membrane MICA Expression: Potential Mechanisms and Correlation With Natural Killer Cell Activity in Systemic Lupus Erythematosus., PMID:34012432

The NKG2D ligand ULBP4 is not expressed by human monocytes., PMID:33556116

NK Cell Interaction With Platelets and Myeloid Cells in the Tumor Milieu., PMID:33424862

NKG2D and MICA/B shedding: a 'tag game' between NK cells and malignant cells., PMID:33363734

A Chimeric Antigen Receptor That Binds to a Conserved Site on MICA., PMID:33037097

Human Metapneumovirus Escapes NK Cell Recognition through the Downregulation of Stress-Induced Ligands for NKG2D., PMID:32698530

Effects of propofol and dexmedetomidine with and without remifentanil on serum cytokine concentrations in healthy volunteers: a post hoc analysis., PMID:32660717

MICAgen Mice Recapitulate the Highly Restricted but Activation-Inducible Expression of the Paradigmatic Human NKG2D Ligand MICA., PMID:32582150

Restoration of antitumor immunity through anti-MICA antibodies elicited with a chimeric protein., PMID:32518090

Antibody targeting tumor-derived soluble NKG2D ligand sMIC reprograms NK cell homeostatic survival and function and enhances melanoma response to PDL1 blockade therapy., PMID:32517713

Inhibition of MICA and MICB Shedding Elicits NK-Cell-Mediated Immunity against Tumors Resistant to Cytotoxic T Cells., PMID:32209637

Enhanced activation of human NK cells by drug-exposed hepatocytes., PMID:32060585

Glycogen synthetase kinase 3 inhibition drives MIC-A/B to promote cytokine production by human natural killer cells in Dengue virus type 2 infection., PMID:31743425

Single droplet detection of immune checkpoints on a multiplexed electrohydrodynamic biosensor., PMID:31657376

Visualization and quantification of NK cell-mediated cytotoxicity over extended time periods by image cytometry., PMID:30951701

Datasheet
$ 328
Product specifications
100 μg 328 1 mg 1640

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For research use only. Not for human or drug use.

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Anti-Human MICB Antibody (SAA1687) [RHH45101]
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