Catalog No.
RHD51701
Species reactivity
Human
Host species
Mouse
Isotype
IgG2a, kappa
Clonality
Monoclonal
Target
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1, NPPS, PC1, NPPase, PDNP1, Membrane component chromosome 6 surface marker 1, ENPP1, Phosphodiesterase I/nucleotide pyrophosphatase 1, M6S1, Plasma-cell membrane glycoprotein PC-1, E-NPP 1, Nucleotide diphosphatase
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P22413
Applications
ELISA
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
SAA1604
Design, Synthesis, and Pharmacological Evaluation of Quinazoline and Quinoline Derivatives as Potent ENPP1 Inhibitors for Cancer Immunotherapy., PMID:39973889
ENPP1/CD203a-targeting heavy-chain antibody reveals cell-specific expression on human immune cells., PMID:39694917
Use of Whole-Exome Sequencing and Pedigree Analysis to Identify X-linked Hypophosphatemia in Saudi Arabian Families., PMID:39659542
A humanized monoclonal antibody targeting an ectonucleotidase rescues cardiac metabolism and heart function after myocardial infarction., PMID:39454569
Discovery of Imidazo[1,2-a]pyrazine Derivatives as Potent ENPP1 Inhibitors., PMID:39357030
Regulation of TGF-β1-induced fibroblast differentiation of human periodontal ligament stem cells through the mutually antagonistic action of ectonucleotide pyrophosphatase/phosphodiesterase 1 and 2., PMID:39291269
Activation of Nuclear Factor Erythroid 2-Related Factor 2 Transcriptionally Upregulates Ectonucleotide Pyrophosphatase/Phosphodiesterase 1 Expression and Inhibits Ectopic Calcification in Mice., PMID:39199142
The use of burosumab to treat autosomal-recessive hypophosphatemic rickets type 2: rationale and a first clinical experience., PMID:38308754
Targeting ENPP1 for cancer immunotherapy: Killing two birds with one stone., PMID:38142838
Surface and Global Proteome Analyses Identify ENPP1 and Other Surface Proteins as Actionable Immunotherapeutic Targets in Ewing Sarcoma., PMID:37812652
Discovery of VH domains that allosterically inhibit ENPP1., PMID:37400538
An atlas of the bone marrow bone proteome in patients with dysproteinemias., PMID:37105956
Human antibodies targeting ENPP1 as candidate therapeutics for cancers., PMID:36761762
An atlas of the bone marrow bone proteome in patients with dysproteinemias., PMID:36747663
The molecular mechanism research of cartilage calcification induced by osteoarthritis., PMID:35611765
Strategies for Glycoengineering Therapeutic Proteins., PMID:35494652
Cardiomyocytes disrupt pyrimidine biosynthesis in nonmyocytes to regulate heart repair., PMID:34813507
Identification of cell surface targets for CAR-T cell therapies and antibody-drug conjugates in breast cancer., PMID:33838601
Development of a High-Throughput Assay to Identify Inhibitors of ENPP1., PMID:33402044
Small molecules targeting the innate immune cGAS‒STING‒TBK1 signaling pathway., PMID:33354501
Validation of a next-generation sequencing (NGS) panel to improve the diagnosis of X-linked hypophosphataemia (XLH) and other genetic disorders of renal phosphate wasting., PMID:33107440
Reversion of arterial calcification by elastin-targeted DTPA-HSA nanoparticles., PMID:32151731
Tissue-nonspecific alkaline phosphatase is an anti-inflammatory nucleotidase., PMID:32028019
Survival of Long-Lived Plasma Cells (LLPC): Piecing Together the Puzzle., PMID:31130955
ENPP1-Fc prevents neointima formation in generalized arterial calcification of infancy through the generation of AMP., PMID:30369595
ATP-degrading ENPP1 is required for survival (or persistence) of long-lived plasma cells., PMID:29259245
Wnt activity is associated with cementum-type transition., PMID:27363895
ENPP1-Fc prevents mortality and vascular calcifications in rodent model of generalized arterial calcification of infancy., PMID:26624227
Decreased expression of ectonucleotidase E-NPP1 in leukocytes from subjects with severe asthma exacerbation., PMID:26405014
Characterization of monoclonal antibodies against porcine pulmonary alveolar macrophages of gnotobiotic miniature swine., PMID:25896759
Asfotase-α improves bone growth, mineralization and strength in mouse models of neurofibromatosis type-1., PMID:24997609
Expression of plasma cell alloantigen 1 defines layered development of B-1a B-cell subsets with distinct innate-like functions., PMID:23169635
Hypophosphatemic rickets., PMID:23108197
Discordant gene expression signatures and related phenotypic differences in lamin A- and A/C-related Hutchinson-Gilford progeria syndrome (HGPS)., PMID:21738662
Characterization of monoclonal antibodies to the plasma cell alloantigen ENPP1., PMID:21466281
A QTL on chromosome 10 modulates cone photoreceptor number in the mouse retina., PMID:21330668
The expression of ecto-nucleotide pyrophosphatase/phosphodiesterase 1 (E-NPP1) is correlated with astrocytic tumor grade., PMID:21195542
Association of a genetic polymorphism in ectonucleotide pyrophosphatase/phosphodiesterase 1 with hepatitis C virus infection and hepatitis C virus core antigen levels in subjects in a hyperendemic area of Japan., PMID:19107338
Porcine ecto-nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1/CD203a): cloning, transcription, expression, mapping, and identification of an NPP1/CD203a epitope for swine workshop cluster 9 (SWC9) monoclonal antibodies., PMID:17064772
Expressional and functional studies of Wolframin, the gene function deficient in Wolfram syndrome, in mice and patient cells., PMID:16087305
Structural basis of allotypes of ecto-nucleotide pyrophosphatase/phosphodiesterase (plasma cell membrane glycoprotein PC-1) in the mouse and rat, and analysis of allele-specific xenogeneic antibodies., PMID:12121276
The nucleoside triphosphate pyrophosphohydrolase isozyme PC-1 directly promotes cartilage calcification through chondrocyte apoptosis and increased calcium precipitation by mineralizing vesicles., PMID:11764218
The basophil activation marker defined by antibody 97A6 is identical to the ectonucleotide pyrophosphatase/phosphodiesterase 3., PMID:11342463
Membrane glycoprotein PC-1 inhibition of insulin receptor function occurs via direct interaction with the receptor alpha-subunit., PMID:10615944
Chondrocyte-derived apoptotic bodies and calcification of articular cartilage., PMID:9501221
Biochemical and molecular identification of distinct forms of alkaline phosphodiesterase I expressed on the apical and basolateral plasma membrane surfaces of rat hepatocytes., PMID:9096610
Overexpression of membrane glycoprotein PC-1 in MDA-MB231 breast cancer cells is associated with inhibition of insulin receptor tyrosine kinase activity., PMID:8923458
Regulation of purified hepatic PC-1 (phosphodiesterase-I/nucleotide pyrophosphatase) by threonine auto(de)phosphorylation and by binding of acidic fibroblast growth factor., PMID:7532398
Divalent cations stabilize the conformation of plasma cell membrane glycoprotein PC-1 (alkaline phosphodiesterase I)., PMID:7998960
For research use only. Not for human or drug use.
