Catalog No.
MVV28102
Species reactivity
Classical swine fever virus (strain Brescia) (CSFV) (Hog cholera virus)
Host species
Mouse
Isotype
IgG2a
Clonality
Monoclonal
Immunogen
Synthesized peptide.
Target
Genome polyprotein, Viroporin p7
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P21530
Applications
ELISA, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
1A037
Structural and Functional Properties of the Hepatitis C Virus p7 Viroporin. PMID: 26258788
Re-evaluating the p7 viroporin structure. PMID: 30333582
Hepatitis C virus proteins: from structure to function. PMID: 23463199
The p7 viroporin of the hepatitis C virus contributes to liver inflammation by stimulating production of Interleukin-1β. PMID: 27979709
Viroporin activity and membrane topology of classic swine fever virus p7 protein. PMID: 23583663
Hepatitis C virus sequence divergence preserves p7 viroporin structural and dynamic features. PMID: 31182749
Functional characterization of p7 viroporin from hepatitis C virus produced in a cell-free expression system. PMID: 26477501
Understanding the inhibitory mechanism of BIT225 drug against p7 viroporin using computational study. PMID: 29169687
Classical swine fever virus p7 protein is a viroporin involved in virulence in swine. PMID: 22496228
SPCS1-Dependent E2-p7 processing determines HCV Assembly efficiency. PMID: 35130329
The amino-terminus of the hepatitis C virus (HCV) p7 viroporin and its cleavage from glycoprotein E2-p7 precursor determine specific infectivity and secretion levels of HCV particle types. PMID: 29253880
Pore-forming activity of pestivirus p7 in a minimal model system supports genus-specific viroporin function. PMID: 24189547
Hepatitis C virus p7-a viroporin crucial for virus assembly and an emerging target for antiviral therapy. PMID: 21994720
Hepatitis C virus p7 mediates membrane-to-membrane adhesion. PMID: 27320856
Single-molecule conformational dynamics of viroporin ion channels regulated by lipid-protein interactions. PMID: 32889489
Inhibitor Development against p7 Channel in Hepatitis C Virus. PMID: 33802584
Subcellular localization and function of an epitope-tagged p7 viroporin in hepatitis C virus-producing cells. PMID: 23175364
Critical Effect of the Detergent:Protein Ratio on the Formation of the Hepatitis C Virus p7 Channel. PMID: 31468972
Ion channel activity of the CSFV p7 viroporin in surrogates of the ER lipid bilayer. PMID: 26464198
Development and validation of a high-throughput screening assay for the hepatitis C virus p7 viroporin. PMID: 21343600
Hepatitis C virus p7 induces mitochondrial depolarization of isolated liver mitochondria. PMID: 29039530
The elusive function of the hepatitis C virus p7 protein. PMID: 25001174
The p7 protein of the hepatitis C virus induces cell death differently from the influenza A virus viroporin M2. PMID: 23246447
Differential effect of p7 inhibitors on hepatitis C virus cell-to-cell transmission. PMID: 24157306
Classical Swine Fever Virus p7 Protein Interacts with Host Protein CAMLG and Regulates Calcium Permeability at the Endoplasmic Reticulum. PMID: 30154321
Patch-Clamp Study of Hepatitis C p7 Channels Reveals Genotype-Specific Sensitivity to Inhibitors. PMID: 27276260
Unusual architecture of the p7 channel from hepatitis C virus. PMID: 23739335
Identification of a novel class of cyclic penta-peptides against hepatitis C virus as p7 channel blockers. PMID: 36382186
Ion hydration dynamics in conjunction with a hydrophobic gating mechanism regulates ion permeation in p7 viroporin from hepatitis C virus. PMID: 25933117
Comparative NMR studies demonstrate profound differences between two viroporins: p7 of HCV and Vpu of HIV-1. PMID: 20727848
The Network of Interactions Between Classical Swine Fever Virus Nonstructural Protein p7 and Host Proteins. PMID: 33329485
Targeting the Channel Activity of Viroporins. PMID: 27038378
Viroporins: structure and biological functions. PMID: 22751485
Rationally derived inhibitors of hepatitis C virus (HCV) p7 channel activity reveal prospect for bimodal antiviral therapy. PMID: 33169665
NMR studies of p7 protein from hepatitis C virus. PMID: 19727701
Computational Docking Study of p7 Ion Channel from HCV Genotype 3 and Genotype 4 and Its Interaction with Natural Compounds. PMID: 26030803
Classical swine fever virus and p7 protein induce secretion of IL-1β in macrophages. PMID: 25146005
Cell viability assay as a tool to study activity and inhibition of hepatitis C p7 channels. PMID: 33709903
Viral proteins function as ion channels. PMID: 20478263
Too little, too late? Will inhibitors of the hepatitis C virus p7 ion channel ever be used in the clinic? PMID: 25495983
Relating structure and function of viral membrane-spanning miniproteins. PMID: 26057606
Characterization of determinants important for hepatitis C virus p7 function in morphogenesis by using trans-complementation. PMID: 19726506
The minimalist architectures of viroporins and their therapeutic implications. PMID: 24055819
NMR structure and ion channel activity of the p7 protein from hepatitis C virus. PMID: 20667830
Unravelling the Immunomodulatory Effects of Viral Ion Channels, towards the Treatment of Disease. PMID: 34834972
Intracellular proton conductance of the hepatitis C virus p7 protein and its contribution to infectious virus production. PMID: 20824094
Genotype-dependent sensitivity of hepatitis C virus to inhibitors of the p7 ion channel. PMID: 18828153
The Unusual Transmembrane Partition of the Hexameric Channel of the Hepatitis C Virus. PMID: 29551287
Molecular design, synthesis and biological evaluation of cage compound-based inhibitors of hepatitis C virus p7 ion channels. PMID: 30218908
The 3-dimensional structure of a hepatitis C virus p7 ion channel by electron microscopy. PMID: 19590017
Viroporins from RNA viruses induce caspase-dependent apoptosis. PMID: 17961183
Coupling neutron reflectivity with cell-free protein synthesis to probe membrane protein structure in supported bilayers. PMID: 28611396
Symmetric dimeric adamantanes for exploring the structure of two viroporins: influenza virus M2 and hepatitis C virus p7. PMID: 29750015
The effect of amantadine on an ion channel protein from Chikungunya virus. PMID: 31339886
Reverse genetic analysis of a putative, influenza virus M2 HXXXW-like motif in the p7 protein of hepatitis C virus. PMID: 19175872
Assessing the physiological relevance of alternate architectures of the p7 protein of hepatitis C virus in different environments. PMID: 27501910
The stability of secreted, acid-labile H77/JFH-1 hepatitis C virus (HCV) particles is altered by patient isolate genotype 1a p7 sequences. PMID: 24314642
Structure-guided design affirms inhibitors of hepatitis C virus p7 as a viable class of antivirals targeting virion release. PMID: 24022996
Top-down mass spectrometry of intact membrane protein complexes reveals oligomeric state and sequence information in a single experiment. PMID: 25970171
Hepatitis C virus nonstructural protein 5B is involved in virus morphogenesis. PMID: 22345449
Hepatitis C virus induces interleukin-1β (IL-1β)/IL-18 in circulatory and resident liver macrophages. PMID: 24006444
In silico identification of Tretinoin as a SARS-CoV-2 envelope (E) protein ion channel inhibitor. PMID: 33126128
Determination of pore-lining residues in the hepatitis C virus p7 protein. PMID: 19167280
NS2 protein of hepatitis C virus interacts with structural and non-structural proteins towards virus assembly. PMID: 21347350
Mean protein evolutionary distance: a method for comparative protein evolution and its application. PMID: 23613826
For research use only. Not for human or drug use.
