Transcriptome analysis of PK-15 cells expressing CSFV NS4A. PMID: 36503524
The NS4A Protein of Classical Swine Fever Virus Suppresses RNA Silencing in Mammalian Cells. PMID: 35867575
Japanese Encephalitis Virus NS4A Protein Interacts with PTEN-Induced Kinase 1 (PINK1) and Promotes Mitophagy in Infected Cells. PMID: 35604158
Determinants of Dengue Virus NS4A Protein Oligomerization. PMID: 25833044
Zika virus NS4A cytosolic region (residues 1-48) is an intrinsically disordered domain and folds upon binding to lipids. PMID: 32871423
Zika Virus-Encoded NS2A and NS4A Strongly Downregulate NF-κB Promoter Activity. PMID: 33203823
Characterization of dengue virus NS4A and NS4B protein interaction. PMID: 25568208
Structure and function of the hepatitis C virus NS3-NS4A serine proteinase. PMID: 10592660
Zika virus NS4A N-Terminal region (1-48) acts as a cofactor for inducing NTPase activity of NS3 helicase but not NS3 protease. PMID: 33080173
Synthetic bulky NS4A peptide variants bind to and inhibit HCV NS3 protease. PMID: 32373358
Tick-borne encephalitis virus NS4A ubiquitination antagonizes type I interferon-stimulated STAT1/2 signalling pathway. PMID: 32196427
1H-Imidazole-2,5-Dicarboxamides as NS4A Peptidomimetics: Identification of a New Approach to Inhibit HCV-NS3 Protease. PMID: 32245218
NS4A and NS4B proteins from dengue virus: membranotropic regions. PMID: 22772157
Genetic interaction between NS4A and NS4B for replication of Japanese encephalitis virus. PMID: 25575708
Intrinsic features of Zika Virus non-structural proteins NS2A and NS4A in the regulation of viral replication. PMID: 35522620
Zika virus non-structural protein NS4A restricts eye growth in Drosophila through regulation of JAK/STAT signaling. PMID: 32152180
Flaviviruses Exploit the Lipid Droplet Protein AUP1 to Trigger Lipophagy and Drive Virus Production. PMID: 29902443
NS4A protein as a marker of HCV history suggests that different HCV genotypes originally evolved from genotype 1b. PMID: 21696641
Secondary structure and membrane topology of dengue virus NS4A protein in micelles. PMID: 29055659
Dengue virus NS4A cytoplasmic domain binding to liposomes is sensitive to membrane curvature. PMID: 25644870
Flavivirus NS4A-induced autophagy protects cells against death and enhances virus replication. PMID: 21511946
Mutations in the cytoplasmic domain of dengue virus NS4A affect virus fitness and interactions with other non-structural proteins. PMID: 32589122
Trimerization of the N-Terminal Tail of Zika Virus NS4A Protein: A Potential In Vitro Antiviral Screening Assay. PMID: 33946585
Mutagenesis of the dengue virus NS4A protein reveals a novel cytosolic N-terminal domain responsible for virus-induced cytopathic effects and intramolecular interactions within the N-terminus of NS4A. PMID: 30707666
Hepatitis C Virus Infection Is Inhibited by a Noncanonical Antiviral Signaling Pathway Targeted by NS3-NS4A. PMID: 31534039
The NS3 and NS4A genes as the targets of RNA interference inhibit replication of Japanese encephalitis virus in vitro and in vivo. PMID: 27593564
HCV non-structural NS4A protein of genotype 3a induces mitochondria mediated death by activating Bax and the caspase cascade. PMID: 30179714
The acidic domain of the hepatitis C virus NS4A protein is required for viral assembly and envelopment through interactions with the viral E1 glycoprotein. PMID: 30730994
Host proteins associated with Hepatitis C virus encoded NS4A. PMID: 25674628
The NS4A protein of hepatitis C virus promotes RNA-coupled ATP hydrolysis by the NS3 helicase. PMID: 19153239
Amino Terminal Region of Dengue Virus NS4A Cytosolic Domain Binds to Highly Curved Liposomes. PMID: 26197333
The NS4A Cofactor Dependent Enhancement of HCV NS3 Protease Activity Correlates with a 4D Geometrical Measure of the Catalytic Triad Region. PMID: 27936126
NS4A regulates the ATPase activity of the NS3 helicase: a novel cofactor role of the non-structural protein NS4A from West Nile virus. PMID: 19474250
Eukaryotic initiation factor 4AI interacts with NS4A of Dengue virus and plays an antiviral role. PMID: 25866185
Cleavage of the dengue virus polyprotein at the NS3/NS4A and NS4B/NS5 junctions is mediated by viral protease NS2B-NS3, whereas NS4A/NS4B may be processed by a cellular protease. PMID: 1531368
[The analysis of immunoreactivity of individual B-cell epitopes of hepatitis C virus (Flaviviridae: Hepacivirus: Hepatitis С virus) NS4a antigen]. PMID: 35831966
Adapted J6/JFH1-based Hepatitis C virus recombinants with genotype-specific NS4A show similar efficacies against lead protease inhibitors, alpha interferon, and a putative NS4A inhibitor. PMID: 24060868
ACH-806, an NS4A antagonist, inhibits hepatitis C virus replication by altering the composition of viral replication complexes. PMID: 23629709
Antagonism of dsRNA-Induced Innate Immune Pathways by NS4a and NS4b Accessory Proteins during MERS Coronavirus Infection. PMID: 30914508
Mechanistic role of an NS4A peptide cofactor with the truncated NS3 protease of hepatitis C virus: elucidation of the NS4A stimulatory effect via kinetic analysis and inhibitor mapping. PMID: 9235976
Adaptive mutation F772S-enhanced p7-NS4A cooperation facilitates the assembly and release of hepatitis C virus and is associated with lipid droplet enlargement. PMID: 30087320
Evaluation of NS4A, NS4B, NS5 and 3'UTR Genetic Determinants of WNV Lineage 1 Virulence in Birds and Mammals. PMID: 37243180
The conformation of hepatitis C virus NS3 proteinase with and without NS4A: a structural basis for the activation of the enzyme by its cofactor. PMID: 9741640
Amino Acid Mutations in the NS4A Region of Hepatitis C Virus Contribute to Viral Replication and Infectious Virus Production. PMID: 27928005
Membrane undulation induced by NS4A of Dengue virus: a molecular dynamics simulation study. PMID: 23964591
Hepatitis C virus-encoded nonstructural protein NS4A has versatile functions in viral protein processing. PMID: 7853491
Mechanistic role of NS4A and substrate in the activation of HCV NS3 protease. PMID: 21633972
Sequential Phosphorylation of the Hepatitis C Virus NS5A Protein Depends on NS3-Mediated Autocleavage between NS3 and NS4A. PMID: 32699091
The cytoplasmic N-terminal tail of Zika virus NS4A protein forms oligomers in the absence of detergent or lipids. PMID: 37147499
The hepatitis C virus NS4A protein: interactions with the NS4B and NS5A proteins. PMID: 9261364
Differential requirements of NS4A for internal NS3 cleavage and polyprotein processing of hepatitis C virus. PMID: 17522200
Dengue Virus Non-Structural Protein 5. PMID: 28441781
Hepatitis C virus NS4A inhibits cap-dependent and the viral IRES-mediated translation through interacting with eukaryotic elongation factor 1A. PMID: 16927014
A central region in the hepatitis C virus NS4A protein allows formation of an active NS3-NS4A serine proteinase complex in vivo and in vitro. PMID: 7769699
Modulation of Kinase Activities In Vitro by Hepatitis C Virus Protease NS3/NS4A Mediated-Cleavage of Key Immune Modulator Kinases. PMID: 36766748
Baseline anti-NS4a antibodies in combination with on-treatment quantitative HCV-RNA reliably identifies nonresponders to pegylated interferon-ribavirin combination therapy after 4 weeks of treatment. PMID: 21389795
A Putative Lipid-Associating Motif in the West Nile Virus NS4A Protein Is Required for Efficient Virus Replication. PMID: 34055786
Grazoprevir/elbasvir fixed-dose combination for hepatitis C. PMID: 27540596
Nonstructural protein precursor NS4A/B from hepatitis C virus alters function and ultrastructure of host secretory apparatus. PMID: 12829824
Use of the fused NS4A peptide-NS3 protease domain to study the importance of the helicase domain for protease inhibitor binding to hepatitis C virus NS3-NS4A. PMID: 19119853
Roles of Non-Structural Protein 4A in Flavivirus Infection. PMID: 34696510
The acidic domain of hepatitis C virus NS4A contributes to RNA replication and virus particle assembly. PMID: 21047963
Conserved amino acids within the N-terminus of the West Nile virus NS4A protein contribute to virus replication, protein stability and membrane proliferation. PMID: 25771497
Zika Virus Proteins NS2A and NS4A Are Major Antagonists that Reduce IFN-β Promoter Activity Induced by the MDA5/RIG-I Signaling Pathway. PMID: 31581385
Expression of NS3/NS4A Proteins of Hepatitis C Virus in Huh7 Cells Following Engineering Its Eukaryotic Expression Vector. PMID: 26862385
Regulated cleavages at the West Nile virus NS4A-2K-NS4B junctions play a major role in rearranging cytoplasmic membranes and Golgi trafficking of the NS4A protein. PMID: 16611922
Codon usage variation of Zika virus: The potential roles of NS2B and NS4A in its global pandemic. PMID: 29428601
Inhibition of hepatitis C virus (HCV) core protein- induced cell growth by non-structural protein 4A (NS4A) is mediated by mitochondrial dysregulation. PMID: 18318665
Neuroimmune Evasion of Zika Virus to Facilitate Viral Pathogenesis. PMID: 34765564
Cellular vimentin regulates construction of dengue virus replication complexes through interaction with NS4A protein. PMID: 24284321
Expression and purification of an active, full-length hepatitis C viral NS4A. PMID: 11049744
Interferon antagonist function of Japanese encephalitis virus NS4A and its interaction with DEAD-box RNA helicase DDX42. PMID: 18588927
Hepatitis C virus RNA replication and virus particle assembly require specific dimerization of the NS4A protein transmembrane domain. PMID: 24173222
Restoration of replication-defective dengue type 1 virus bearing mutations in the N-terminal cytoplasmic portion of NS4A by additional mutations in NS4B. PMID: 20882304
Zika Virus NS4A and NS4B Proteins Deregulate Akt-mTOR Signaling in Human Fetal Neural Stem Cells to Inhibit Neurogenesis and Induce Autophagy. PMID: 27524440
A novel interaction between dengue virus nonstructural protein 1 and the NS4A-2K-4B precursor is required for viral RNA replication but not for formation of the membranous replication organelle. PMID: 31071189
Both NS3 and NS4A are required for proteolytic processing of hepatitis C virus nonstructural proteins. PMID: 8189513
Enhancement of hepatitis C virus NS3 proteinase activity by association with NS4A-specific synthetic peptides: identification of sequence and critical residues of NS4A for the cofactor activity. PMID: 8918919
A novel recombinant single-chain hepatitis C virus NS3-NS4A protein with improved helicase activity. PMID: 10386883
Identification of the sequence on NS4A required for enhanced cleavage of the NS5A/5B site by hepatitis C virus NS3 protease. PMID: 8523516
Faldaprevir for the treatment of hepatitis C. PMID: 26097902
Discovery of Dengue Virus Inhibitors. PMID: 30514185
Nonstructural proteins NS2-3 and NS4A of classical swine fever virus: essential features for infectious particle formation. PMID: 17482232
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