NS5A Resistance: Clinical Implications and Treatment Possibilities. PMID: 26991826
NS5A inhibitors for the treatment of hepatitis C infection. PMID: 27925362
Should NS5A inhibitors serve as the scaffold for all-oral anti-HCV combination therapies? PMID: 25926761
In Silico Approaches to the Design of NS5A Inhibitors. PMID: 26585932
NS5A--from obscurity to new target for HCV therapy. PMID: 18673121
Hepatitis C virus NS5A inhibitors and drug resistance mutations. PMID: 24659881
Hepatitis C virus NS5A: enigmatic but still promiscuous 10 years on! PMID: 25481754
Hepatitis C NS5A protein: two drug targets within the same protein with different mechanisms of resistance. PMID: 24879295
HCV NS5A: A Multifunctional Regulator of Cellular Pathways and Virus Replication. PMID: 21250384
HCV-2a NS5A downregulates viral translation predominantly through domain I. PMID: 32560823
Hepatitis C virus NS5A: tales of a promiscuous protein. PMID: 15302943
Antiviral activity and resistance of HCV NS5A replication complex inhibitors. PMID: 23896281
HCV NS5A hyperphosphorylation is involved in viral translation modulation. PMID: 31585734
Approaches to hepatitis C treatment and cure using NS5A inhibitors. PMID: 24623983
Discovery and Development of Hepatitis C Virus Inhibitors Targeting the NS5A Protein. PMID: 25723459
Resistance patterns associated with HCV NS5A inhibitors provide limited insight into drug binding. PMID: 25384189
Small-molecule inhibitors of hepatitis C virus (HCV) non-structural protein 5A (NS5A): a patent review (2010-2015). PMID: 27967269
Hepatitis C resistance to NS5A inhibitors: Is it going to be a problem? PMID: 30310532
Phosphorylation of hepatitis C virus NS5A nonstructural protein: a new paradigm for phosphorylation-dependent viral RNA replication? PMID: 17400273
The nonstructural NS5A protein of hepatitis C virus: an expanding, multifunctional role in enhancing hepatitis C virus pathogenesis. PMID: 12065893
NS5A phosphorylation and hyperphosphorylation. PMID: 19009256
MxB Disrupts Hepatitis C Virus NS5A-CypA Complex: Insights From a Combined Theoretical and Experimental Approach. PMID: 35369502
NS5A-ISGylation via Lysine 26 Has a Critical Role for Efficient Propagation of Hepatitis C Virus Genotype 2a. PMID: 34795154
CSFV protein NS5A activates the unfolded protein response to promote viral replication. PMID: 32056717
Perilipin 5 alleviates HCV NS5A-induced lipotoxic injuries in liver. PMID: 30954078
Repression of the PKR protein kinase by the hepatitis C virus NS5A protein: a potential mechanism of interferon resistance. PMID: 9741641
Sequential Phosphorylation of Hepatitis C Virus NS5A Protein Requires the ATP-Binding Domain of NS3 Helicase. PMID: 35293767
HCV NS5A dimer interface residues regulate HCV replication by controlling its self-interaction, hyperphosphorylation, subcellular localization and interaction with cyclophilin A. PMID: 30036383
NS5A-P32 deletion as a factor involved in virologic failure in patients receiving glecaprevir and pibrentasvir. PMID: 30612205
The NS5A protein of hepatitis C virus transcriptionally upregulates the AGR3 gene expression. PMID: 25868611
ISGylation of Hepatitis C Virus NS5A Protein Promotes Viral RNA Replication via Recruitment of Cyclophilin A. PMID: 32727878
HSP90AA1 interacts with CSFV NS5A protein and regulates CSFV replication via the JAK/STAT and NF-κB signaling pathway. PMID: 36405689
Prevalence of Naturally-Occurring NS5A and NS5B Resistance-Associated Substitutions in Iranian Patients With Chronic Hepatitis C Infection. PMID: 33584581
Efficacy of NS5A inhibitors against unusual and potentially difficult-to-treat HCV subtypes commonly found in sub-Saharan Africa and South East Asia. PMID: 32470499
Synergistic Activity of Combined NS5A Inhibitors. PMID: 26711745
Natural NS5A inhibitor resistance associated substitutions in hepatitis C virus genotype 1 infected patients from Italy. PMID: 28811242
Discovery of fluorobenzimidazole HCV NS5A inhibitors. PMID: 27780635
The Relationship Between HCV-NS5A Gene Mutations and Resistance to Combination Therapy in Patients with HCV- Genotype 1-B. PMID: 34604413
Comparative Analysis of Hepatitis C Virus NS5A Dynamics and Localization in Assembly-Deficient Mutants. PMID: 33557275
Baseline NS5A resistance associated substitutions may impair DAA response in real-world hepatitis C patients. PMID: 28990680
NS5A domain I antagonises PKR to facilitate the assembly of infectious hepatitis C virus particles. PMID: 36795772
Interaction study between HCV NS5A-D2 and NS5B using 19F NMR. PMID: 29218486
HCV NS5A co-operates with PKR in modulating HCV IRES-dependent translation. PMID: 24815730
NS5A Sequence Heterogeneity and Mechanisms of Daclatasvir Resistance in Hepatitis C Virus Genotype 4 Infection. PMID: 26170396
A short hepatitis C virus NS5A peptide expression by AAV vector modulates human T cell activation and reduces vector immunogenicity. PMID: 34759330
The Hepatitis C virus NS5A and core proteins exert antagonistic effects on HAMP gene expression: the hidden interplay with the MTF-1/MRE pathway. PMID: 33247551
Dimer Organization of Membrane-Associated NS5A of Hepatitis C Virus as Determined by Highly Sensitive 1 H-Detected Solid-State NMR. PMID: 33205864
Sequential Phosphorylation of the Hepatitis C Virus NS5A Protein Depends on NS3-Mediated Autocleavage between NS3 and NS4A. PMID: 32699091
NS5A inhibitors impair NS5A-phosphatidylinositol 4-kinase IIIα complex formation and cause a decrease of phosphatidylinositol 4-phosphate and cholesterol levels in hepatitis C virus-associated membranes. PMID: 25224012
Domain I of hepatitis C virus NS5A associates with ACBD3 in a genotype-dependent manner. PMID: 32108375
Design and Synthesis of Novel Bis-Imidazolyl Phenyl Butadiyne Derivatives as HCV NS5A Inhibitors. PMID: 35631457
Characterizations of HCV NS5A replication complex inhibitors. PMID: 23896639
Linkage of resistance-associated substitutions in GT1 sofosbuvir + NS5A inhibitor failures treated with glecaprevir/pibrentasvir. PMID: 34023351
Correlation between NS5A dimerization and hepatitis C virus replication. PMID: 22801423
HCV NS5A interacts with p53 and inhibits p53-mediated apoptosis. PMID: 12101418
Studies of the symmetric binding mode of daclatasvir and analogs using a new homology model of HCV NS5A GT-4a. PMID: 36580076
The NS5A protein of hepatitis C virus is a zinc metalloprotein. PMID: 15339921
Analysis of functional differences between hepatitis C virus NS5A of genotypes 1-7 in infectious cell culture systems. PMID: 22654662
The incidence of resistance-associated variants to NS5A in HCV subtypes 1a and 1b in Taiwan. PMID: 35123932
An NS5A single optimized method to determine genotype, subtype and resistance profiles of Hepatitis C strains. PMID: 28727784
The effects of NS5A inhibitors on NS5A phosphorylation, polyprotein processing and localization. PMID: 21795470
Hepatitis C virus NS5A disrupts STAT1 phosphorylation and suppresses type I interferon signaling. PMID: 22674974
Phosphoproteomics Identified an NS5A Phosphorylation Site Involved in Hepatitis C Virus Replication. PMID: 26702051
HCV NS5A protein containing potential ligands for both Src homology 2 and 3 domains enhances autophosphorylation of Src family kinase Fyn in B cells. PMID: 23077515
Serine 229 Balances the Hepatitis C Virus Nonstructural Protein NS5A between Hypo- and Hyperphosphorylated States. PMID: 31511391
Protein tyrosine kinase Abl promotes hepatitis C virus particle assembly via interaction with viral substrate activator NS5A. PMID: 35257746
HCV NS5A abrogates p53 protein function by interfering with p53-DNA binding. PMID: 15259070
Pharmacological disruption of hepatitis C NS5A protein intra- and intermolecular conformations. PMID: 23997183
IL28A protein homotetramer structure is required for autolysosomal degradation of HCV-NS5A in vitro. PMID: 32205851
Daclatasvir inhibits hepatitis C virus NS5A motility and hyper-accumulation of phosphoinositides. PMID: 25546252
Phosphorylation of Serine 225 in Hepatitis C Virus NS5A Regulates Protein-Protein Interactions. PMID: 28615203
Serine 235 Is the Primary NS5A Hyperphosphorylation Site Responsible for Hepatitis C Virus Replication. PMID: 28446668
NS5A protein of HCV enhances HBV replication and resistance to interferon response. PMID: 17532300
HCV NS5A inhibits interferon-alpha signaling through suppression of STAT1 phosphorylation in hepatocyte-derived cell lines. PMID: 17275127
Subtype-Specific Prevalence of Hepatitis C Virus NS5A Resistance Associated Substitutions in Mainland China. PMID: 30941111
Involvement of hepatitis C virus NS5A hyperphosphorylation mediated by casein kinase I-α in infectious virus production. PMID: 24760886
Self-association and conformational variation of NS5A domain 1 of hepatitis C virus. PMID: 29300159
The NS5A protein of bovine viral diarrhoea virus interacts with the alpha subunit of translation elongation factor-1. PMID: 11714969
Prevalence of baseline HCV NS5A resistance associated substitutions in genotype 1a, 1b and 3 infection in Australia. PMID: 31606586
Synthesis and evaluation of NS5A inhibitors containing diverse heteroaromatic cores. PMID: 25577039
For research use only. Not for human or drug use.
