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Anti-Human HERV-K Env/ERVK-6 Antibody (2I5/H4) (RHK06501)

Host species:Mouse
Isotype:IgG2a, kappa
Applications:ELISA, WB
Accession:Q69384
Overview

Catalog No.

RHK06501

Species reactivity

Human

Host species

Mouse

Isotype

IgG2a, kappa

Clonality

Monoclonal

Target

Endogenous retrovirus group K member 6 Env polyprotein, EnvK2 protein, Envelope polyprotein, HERV-K(C7) envelope protein, HERV-K(HML-2.HOM) envelope protein, HERV-K108 envelope protein, HERV-K_7p22.1 provirus ancestral Env polyprotein, Surface protein, SU, Transmembrane protein, TM, ERVK-6, ERVK6

Concentration

1.62 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q69384

Applications

ELISA, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Alternative Names

HERM-1811-5, HERM 1811-5, HERM1811-5

Clone ID

2I5/H4

Data Image
  • Bioactivity
    Detects Human ERVK-6/HERV-K Env in indirect ELISAs.
  • WESTERN BLOT
    Various lysates were subjected to SDS PAGE followed by western blot with HERV-K Env/ERVK-6 antibody (RHK06501) at 1µg/ml.

    Lane 1: Human HERV-K Env/ERVK-6 transfected HEK293 cell lysate
    Lane 2: Non-transfected HEK293 cell lysate

    Second Ab: Goat Anti-Mouse IgG H&L Polyclonal antibody, HRP (PMB96431) at 0.1 μg/mL.

    Predict MW: 62 kDa
    Observed MW: 62 kDa
References

The Role of HERV-K in Cancer Stemness. PMID: 36146825

Activation of HERV-K(HML-2) disrupts cortical patterning and neuronal differentiation by increasing NTRK3. PMID: 33951478

Monocyte-released HERV-K dUTPase engages TLR4 and MCAM causing endothelial mesenchymal transition. PMID: 34185707

Ancient Adversary - HERV-K (HML-2) in Cancer. PMID: 34055625

Human endogenous retrovirus-K (HML-2): a comprehensive review. PMID: 30318978

HERV-K inactive or potential pathogens from within? PMID: 33640108

HERV-K(HML-2), a seemingly silent subtenant - but still waters run deep. PMID: 26818263

High Expression of HERV-K (HML-2) Might Stimulate Interferon in COVID-19 Patients. PMID: 35632738

HERV-K and HERV-W transcriptional activity in myalgic encephalomyelitis/chronic fatigue syndrome. PMID: 32257068

HERV-K and W expression in peripheral mononuclear cells of children with Henoch-Sch枚nlein purpura and relation with TLR activation. PMID: 28472872

Is HERV-K and HERV-W expression regulated by mir-155 in S茅zary Syndrome? PMID: 29582620

HERV-K Gag RNA and Protein Levels Are Elevated in Malignant Regions of the Prostate in Males with Prostate Cancer. PMID: 33802118

Human endogenous retrovirus HERV-K(HML-2) RNA causes neurodegeneration through Toll-like receptors. PMID: 32271161

TDP-43 and HERV-K Envelope-Specific Immunogenic Epitopes Are Recognized in ALS Patients. PMID: 34835107

Increased HERV-K(HML-2) Transcript Levels Correlate with Clinical Parameters of Liver Damage in Hepatitis C Patients. PMID: 33807462

Human endogenous retrovirus-K (HERV-K) reverse transcriptase (RT) structure and biochemistry reveals remarkable similarities to HIV-1 RT and opportunities for HERV-K-specific inhibition. PMID: 35771941

Structural Mimicry Drives HIV-1 Rev-Mediated HERV-K Expression. PMID: 33197463

Human endogenous retrovirus K (HERV-K) env in neuronal extracellular vesicles: a new biomarker of motor neuron disease. PMID: 34151656

Association of HERV-K and LINE-1 hypomethylation with reduced disease-free survival in melanoma patients. PMID: 33125285

HERV-K HML-2 diversity among humans. PMID: 27071126

Epstein Barr virus induces HERV-K and HERV-W expression in pediatrics liver transplant recipients? PMID: 26677952

Not all viruses cause disease: HERV-K(HML-2) in healthy human tissues. PMID: 36315578

Anti-HERV-K (HML-2) capsid antibody responses in HIV elite controllers. PMID: 28830571

Human endogenous retroviruses HERV-H, HERV-W and HERV-K in preeclampsia. PMID: 30756547

HERV-K activation is strictly required to sustain CD133+ melanoma cells with stemness features. PMID: 28125999

The HERV-K accessory protein Np9 controls viability and migration of teratocarcinoma cells. PMID: 30818388

Human Endogenous Retrovirus (HERV)-K env Gene Knockout Affects Tumorigenic Characteristics of nupr1 Gene in DLD-1 Colorectal Cancer Cells. PMID: 33920455

Expression profiles of human endogenous retrovirus (HERV)-K and HERV-R Env proteins in various cancers. PMID: 33691904

Formation of HERV-K and HERV-Fc1 Envelope Family Members is Suppressed on Transcriptional and Translational Level. PMID: 33113941

HERV-K-specific T cells eliminate diverse HIV-1/2 and SIV primary isolates. PMID: 23143309

Clinical significance of human endogenous retrovirus K (HERV-K) in multiple myeloma progression. PMID: 36522589

Human Endogenous Retrovirus K (HERV-K) can drive gene expression as a promoter in Caenorhabditis elegans. PMID: 32867919

Comprehensive identification and characterization of the聽HERV-K (HML-9) group in the human genome. PMID: 35676699

The HERV-K human endogenous retrovirus envelope protein antagonizes Tetherin antiviral activity. PMID: 25210194

Inhibition of HERV-K (HML-2) in amyotrophic lateral sclerosis patients on antiretroviral therapy. PMID: 33653604

CMV induces HERV-K and HERV-W expression in kidney transplant recipients. PMID: 26071331

Widespread expression of the ancient HERV-K (HML-2) provirus group in normal human tissues. PMID: 36256614

HERV-K hypomethylation in ovarian clear cell carcinoma is associated with a poor prognosis and platinum resistance. PMID: 21330831

The role of endogenous retroviruses-K in human cancer. PMID: 32734655

HERV-K (HML-2) insertion polymorphisms in the 8q24.13 region and their potential etiological associations with acute myeloid leukemia. PMID: 36988711

Elevated HERV-K mRNA expression in PBMC is associated with a prostate cancer diagnosis particularly in older men and smokers. PMID: 24858205

Is HERV-K and HERV-W Expression Regulated by miR-155 in Kidney Transplant Patients with Human Cytomegalovirus Infection? PMID: 29991021

Does HERV-K represent a potential therapeutic target for prostate cancer? PMID: 28847189

Low HERV-K(C4) copy number is associated with type 1 diabetes. PMID: 24430436

Differential expression of an endogenous retroviral element [HERV-K(HML-6)] is associated with reduced survival in glioblastoma patients. PMID: 35477752

HIV-1 Rev interacts with HERV-K RcREs present in the human genome and promotes export of unspliced HERV-K proviral RNA. PMID: 31842941

Development of an antigen-capture ELISA for the detection of the p27-CA protein of HERV-K(HML-2). PMID: 27142113

Human Endogenous Retrovirus K in Cancer: A Potential Biomarker and Immunotherapeutic Target. PMID: 32640516

Detection of Human Endogenous Retrovirus K (HERV-K) Transcripts in Human Prostate Cancer Cell Lines. PMID: 23847768

First-episode schizophrenia is associated with a reduction of HERV-K methylation in peripheral blood. PMID: 30537669

Molecular mechanisms by which HERV-K Gag interferes with HIV-1 Gag assembly and particle infectivity. PMID: 28446240

Lack of correlation between HERV-K expression and HIV-1 viral load in plasma specimens. PMID: 23694785

Human-specific HERV-K insertion causes genomic variations in the human genome. PMID: 23593260

Human endogenous retrovirus K (HERV-K) is expressed in villous and extravillous cytotrophoblast cells of the human placenta. PMID: 21840605

Downregulation of Human Endogenous Retrovirus Type K (HERV-K) Viral env RNA in Pancreatic Cancer Cells Decreases Cell Proliferation and Tumor Growth. PMID: 28679769

Quantitative analysis of human endogenous retrovirus-K transcripts in postmortem premotor cortex fails to confirm elevated expression of HERV-K RNA in amyotrophic lateral sclerosis. PMID: 30885274

Identification of a HERV-K env surface peptide highly recognized in Rheumatoid Arthritis (RA) patients: a cross-sectional case-control study. PMID: 28324619

Detection of HERV-K(HML-2) viral RNA in plasma of HIV type 1-infected individuals. PMID: 17067267

Transactivation of human endogenous retrovirus K (HERV-K) by KSHV promotes Kaposi's sarcoma development. PMID: 29743595

Endogenous human retrovirus-K is not increased in the affected tissues of Japanese ALS patients. PMID: 35122916

A HERV-K provirus in chimpanzees, bonobos and gorillas, but not humans. PMID: 11378389

Cross-sectional dating of novel haplotypes of HERV-K 113 and HERV-K 115 indicate these proviruses originated in Africa before Homo sapiens. PMID: 19666991

Expression of HERV Genes as Possible Biomarker and Target in Neurodegenerative Diseases. PMID: 31362360

Functional activity of HERV-K-T47D-related long terminal repeats. PMID: 11336551

HIV-associated motor neuron disease: HERV-K activation and response to antiretroviral therapy. PMID: 27664983

HERVs in neuropathogenesis. PMID: 20422298

Human endogenous retrovirus (HERV-K) reverse transcriptase as a breast cancer prognostic marker. PMID: 18516289

HERV-K-T47D-Related long terminal repeats mediate polyadenylation of cellular transcripts. PMID: 10843810

Human Endogenous Retrovirus Type K (HERV-K) Particles Package and Transmit HERV-K-Related Sequences. PMID: 25926654

Saliva antibody-fingerprint of reactivated latent viruses after mild/asymptomatic COVID-19 is unique in patients with myalgic-encephalomyelitis/chronic fatigue syndrome. PMID: 36341457

DNA methylation and transcription in HERV (K, W, E) and LINE sequences remain unchanged upon foreign DNA insertions. PMID: 26627183

Expression-analysis of the human endogenous retrovirus HERV-K in human astrocytic tumors. PMID: 24642114

HERV-K(HML-2) GAG/ENV antibodies as indicator for therapy effect in patients with germ cell tumors. PMID: 15095315

Effect of human endogenous retrovirus-K env gene knockout on proliferation of ovarian cancer cells. PMID: 35802343

Developmental expression of HERV-R (ERV3) and HERV-K in human tissue. PMID: 12083821

Human endogenous retrovirus HERV-K(HML-2) Rec expression and transcriptional activities in normal and rheumatoid arthritis synovia. PMID: 16395745

Vaccination directed against the human endogenous retrovirus-K (HERV-K) gag protein slows HERV-K gag expressing cell growth in a murine model system. PMID: 24669861

Insertion of an HERV(K) LTR in the intron of NBPF3 is not required for its transcriptional activity. PMID: 17391723

Diminished humoral responses against and reduced gene expression levels of human endogenous retrovirus-K (HERV-K) in psoriasis. PMID: 25224121

Variant splicing and influence of ionizing radiation on human endogenous retrovirus K (HERV-K) transcripts in cancer cell lines. PMID: 24204631

Increase in human endogenous retrovirus HERV-K (HML-2) viral load in active rheumatoid arthritis. PMID: 19703019

Expression of HERV-K108 envelope interferes with HIV-1 production. PMID: 28605635

HIV-1 infection increases the expression of human endogenous retroviruses type K (HERV-K) in vitro. PMID: 17263641

The human endogenous retrovirus family HERV-K(HML-3). PMID: 12213204

Detection of T lymphocytes specific for human endogenous retrovirus K (HERV-K) in patients with seminoma. PMID: 16438646

Human endogenous retrovirus HERV-K(HML-2) env expression is not associated with markers of immunosenescence. PMID: 28774724

A new Real-Time-RT-PCR for quantitation of human endogenous retroviruses type K (HERV-K) RNA load in plasma samples: increased HERV-K RNA titers in HIV-1 patients with HAART non-suppressive regimens. PMID: 16678919

Regulation of stem cell function and neuronal differentiation by HERV-K via mTOR pathway. PMID: 32669437

Identification and Characterization of the HERV-K (HML-8) Group of Human Endogenous Retroviruses in the Genome. PMID: 36656667

The transmembrane protein of the human endogenous retrovirus--K (HERV-K) modulates cytokine release and gene expression. PMID: 23950929

Mechanisms of HERV-K (HML-2) Transcription during Human Mammary Epithelial Cell Transformation. PMID: 29046454

Technical considerations in detection of HERV-K in amyotrophic lateral sclerosis: selection of controls and the perils of qPCR. PMID: 31269986

Human endogenous retrovirus (HERV)-K transcripts in gonadoblastomas and gonadoblastoma-derived germ cell tumours. PMID: 10071229

Human endogenous retrovirus K in the respiratory tract is associated with COVID-19 physiopathology. PMID: 35459226

Inhibition of human endogenous retrovirus-K by antiretroviral drugs. PMID: 28330477

Response to the Letter from Garcia-Montojo and colleagues concerning our paper entitled, Quantitative analysis of human endogenous retrovirus-K transcripts in postmortem premotor cortex fails to confirm elevated expression of HERV-K RNA in amyotrophic lateral sclerosis. PMID: 31269988

Presence of dUTPase in the various human endogenous retrovirus K (HERV-K) families. PMID: 14745533

Comparative longitudinal studies of HERV-K and HIV-1 RNA titers in HIV-1-infected patients receiving successful versus unsuccessful highly active antiretroviral therapy. PMID: 17919102

Human endogenous retrovirus K (HERV-K) rec mRNA is expressed in primary melanoma but not in benign naevi or normal skin. PMID: 23311654

Quantitation of HERV-K env gene expression and splicing in human breast cancer. PMID: 12629516

Phylogenetic analysis of HERV-K LTR-like elements in primates: presence in some new world monkeys and evidence of recent parallel evolution in these species and in homo sapiens. PMID: 10550675

Cumulative Roles for Epstein-Barr Virus, Human Endogenous Retroviruses, and Human Herpes Virus-6 in Driving an Inflammatory Cascade Underlying MS Pathogenesis. PMID: 34790199

Gorillas have been infected with the HERV-K (HML-2) endogenous retrovirus much more recently than humans and chimpanzees. PMID: 30610173

Identification of the protease cleavage sites in a reconstituted Gag polyprotein of an HERV-K(HML-2) element. PMID: 21554716

Human-specific integrations of the HERV-K endogenous retrovirus family. PMID: 9811713

Datasheet
$ 328
Product specifications
100 μg 328 1 mg 1640

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Anti-Human HERV-K Env/ERVK-6 Antibody (2I5/H4) [RHK06501]
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