Catalog No.
YMG54901
Expression system
E. coli
Species
Mus musculus (Mouse)
Protein length
Gln22-Ser222
Predicted molecular weight
24.07 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q61826
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Mucosal addressin cell adhesion molecule 1, MAdCAM-1, mMAdCAM-1, Madcam1
Gut-directed therapeutics in inflammatory bowel disease., PMID:40305008
An SSTR2-somatostatin chemotactic axis drives T cell progenitor homing to the intestines., PMID:40140497
A screening system to determine the effect of bacterial metabolites on MAdCAM-1 expression by transformed endothelial sinusoidal cells., PMID:40058956
Mucosal Addressin Cell Adhesion Molecule-1 Mediates T Cell Migration into Pancreas-Draining Lymph Nodes for Initiation of the Autoimmune Response in Type 1 Diabetes., PMID:39518902
Elevated levels of peripheral and central nervous system immune markers reflect innate immune dysregulation in autism spectrum disorder., PMID:39481220
Oral reovirus reshapes the gut microbiome and enhances antitumor immunity in colon cancer., PMID:39438458
Predictors of the efficacy of vedolizumab in patients with ulcerative colitis., PMID:39355361
Distinct Transcript-Level Expression Profiles and Unique Alternative Splicing in Inflammatory Myopathies., PMID:39073022
miR-200c-3p regulates α4 integrin-mediated T cell adhesion and migration., PMID:38936759
Exploring the therapeutic potential of porphyran extracted from Porphyra haitanensis in the attenuation of DSS-induced intestinal inflammation., PMID:38788872
Meningeal lymphatic CGRP signaling governs pain via cerebrospinal fluid efflux and neuroinflammation in migraine models., PMID:38743922
MAdCAM-1 co-stimulation combined with retinoic acid and TGF-β induces blood CD8+ T cells to adopt a gut CD101+ TRM phenotype., PMID:38729611
Selective Targeting of α4β7/MAdCAM-1 Axis Suppresses Fibrosis Progression by Reducing Proinflammatory T Cell Recruitment to the Liver., PMID:38727292
Gut-associated lymphoid tissue attrition associates with response to anti-α4β7 therapy in ulcerative colitis., PMID:38640252
Intestinal MAdCAM-1 imaging as biomarker for prognostic in murine models of multiple sclerosis., PMID:38604270
NGFR regulates stromal cell activation in germinal centers., PMID:38307025
Blocking GPR15 Counteracts Integrin-dependent T Cell Gut Homing in Vivo., PMID:38243565
TRPV1 controls innate immunity during Citrobacter rodentium enteric infection., PMID:38109366
Efficacy and Safety of the Anti-mucosal Addressin Cell Adhesion Molecule-1 Antibody Ontamalimab in Patients with Moderate-to-Severe Ulcerative Colitis or Crohn's Disease., PMID:38096402
The V2 domain of HIV gp120 mimics an interaction between CD4 and integrin ⍺4β7., PMID:38064524
The Force-Dependent Mechanism of an Integrin α4β7-MAdCAM-1 Interaction., PMID:38003252
Evolutionary origin and structural ligand mimicry by the inserted domain of alpha-integrin proteins., PMID:37986796
Vedolizumab Efficacy Is Associated With Decreased Intracolonic Dendritic Cells, Not Memory T Cells., PMID:37837660
Machine Learning-Based Quantification of Patient Factors Impacting Remission in Patients With Ulcerative Colitis: Insights from Etrolizumab Phase III Clinical Trials., PMID:37828747
MAdCAM-1 targeting strategy can prevent colitic cancer carcinogenesis and progression via suppression of immune cell infiltration and inflammatory signals., PMID:37676657
An update on the safety of long-term vedolizumab use in inflammatory bowel disease., PMID:37610086
TRPV1 controls innate immunity during Citrobacter rodentium enteric infection., PMID:37546968
Mucosal α4β7+ Lymphocytes and MAdCAM+ Venules Predict Response to Vedolizumab in Ulcerative Colitis., PMID:37436917
CrebH protects against liver injury associated with colonic inflammation via modulation of exosomal miRNA., PMID:37370191
A microbiota-modulated checkpoint directs immunosuppressive intestinal T cells into cancers., PMID:37289890
Distinct bidirectional regulation of LFA1 and α4β7 by Rap1 and integrin adaptors in T cells under shear flow., PMID:37267105
Differential Effects of Ontamalimab Versus Vedolizumab on Immune Cell Trafficking in Intestinal Inflammation and Inflammatory Bowel Disease., PMID:37208197
Force-Regulated Calcium Signaling of Lymphoid Cell RPMI 8226 Mediated by Integrin α4β7/MAdCAM-1 in Flow., PMID:37189336
A pediatric case of infliximab-resistant ulcerative colitis successfully treated using vedolizumab., PMID:37164738
Transcriptional derepression of CHD4/NuRD-regulated genes in the muscle of patients with dermatomyositis and anti-Mi2 autoantibodies., PMID:37130727
Urinary complement proteins in IgA nephropathy progression from a relative quantitative proteomic analysis., PMID:37065697
Anti-β7 integrin treatment impedes the recruitment on non-classical monocytes to the gut and delays macrophage-mediated intestinal wound healing., PMID:37029786
The Underappreciated Role of Secretory IgA in IBD., PMID:36943800
MAdCAM-1 costimulation in the presence of retinoic acid and TGF-β promotes HIV infection and differentiation of CD4+ T cells into CCR5+ TRM-like cells., PMID:36897929
Total flavone of flowers of Abelmoschus manihot (L.) Medic inhibits the expression of adhesion molecules in primary mesenteric arterial endothelial cells and ameliorates dextran sodium sulphate-induced ulcerative colitis in mice., PMID:36857970
MAdCAM-1 does not play a central role in the early pathophysiology of autoimmune hepatitis., PMID:36841352
Novel diagnostic biomarkers of T cell-mediated tumor killing characteristics for early-stage triple negative breast cancer: A SEER analysis and molecular portraits., PMID:36827041
Intestinal Barrier Dysfunction and Microbial Translocation in Patients with First-Diagnosed Atrial Fibrillation., PMID:36672684
MiR-155-5p-SOCS1/JAK1/STAT1 participates in hepatic lymphangiogenesis in liver fibrosis and cirrhosis by regulating M1 macrophage polarization., PMID:36651907
Fibroblastic reticular cells orchestrate long-term graft survival following recipient treatment with CD40 ligand-targeted costimulatory blockade., PMID:36519546
Delivery of costimulatory blockade to lymph nodes promotes transplant acceptance in mice., PMID:36519543
Mucosal Addressin Cell Adhesion Molecule 1 Expression Reflects Mucosal Inflammation and Subsequent Relapse in Patients with Ulcerative Colitis., PMID:36511086
An NKX-COUP-TFII morphogenetic code directs mucosal endothelial addressin expression., PMID:36460642
Expression and function of α4β7 integrin predict the success of vedolizumab treatment in inflammatory bowel disease., PMID:36272713
Distinct immune signature predicts progression of vestibular schwannoma and unveils a possible viral etiology., PMID:36195959
For research use only. Not for human or drug use.
