Catalog No.
YMK99401
Expression system
E. coli
Species
Mus musculus (Mouse)
Protein length
Val27-Val307
Predicted molecular weight
33.43 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q8R464
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Nectin-like protein 4, Igsf4c, NECL-4, Cell adhesion molecule 4, TSLC1-like protein 2, Cadm4, Necl4, Tsll2, IgSF4C, Immunoglobulin superfamily member 4C
Topology-driven discovery of transmembrane protein S-palmitoylation., PMID:39909380
Neuroplasticity and neuroimmune interactions in fatal asthma., PMID:39484998
Palmitoylation regulates myelination by modulating the ZDHHC3-Cadm4 axis in the central nervous system., PMID:39327467
Integrative transcriptome and proteome analyses of clear cell renal cell carcinoma develop a prognostic classifier associated with thrombus., PMID:37328520
Indispensable role of Nectin-like 4 in regulating synapse-related molecules, synaptic structure, and individual behavior., PMID:37184041
Clinicopathological Significance of Cell Adhesion Molecule 4 Expression in Gallbladder Cancer and Its Prognostic Role., PMID:37108061
Involvement of membrane palmitoylated protein 2 (MPP2) in the synaptic molecular complex at the mouse cerebellar glomerulus., PMID:35854144
Age-Dependent Increase in Schmidt-Lanterman Incisures and a Cadm4-Associated Membrane Skeletal Complex in Fatty Acid 2-hydroxylase Deficient Mice: a Mouse Model of Spastic Paraplegia SPG35., PMID:35445918
Trans-homophilic interaction of CADM1 promotes organ infiltration of T-cell lymphoma by adhesion to vascular endothelium., PMID:35213073
Activation of Annexin A2 signaling at the blood-brain barrier in a mouse model of multiple sclerosis., PMID:35064931
A CADM3 variant causes Charcot-Marie-Tooth disease with marked upper limb involvement., PMID:33889941
Differential Contribution of Cadm1-Cadm3 Cell Adhesion Molecules to Peripheral Myelinated Axons., PMID:33397712
Cell adhesion molecule 4 suppresses cell growth and metastasis by inhibiting the Akt signaling pathway in non-small cell lung cancer., PMID:32325280
Structures and Molecular Composition of Schmidt-Lanterman Incisures., PMID:31760645
Coordinated internodal and paranodal adhesion controls accurate myelination by oligodendrocytes., PMID:31451613
Necl-4/Cadm4 recruits Par-3 to the Schwann cell adaxonal membrane., PMID:30585357
Axoglial Adhesion by Cadm4 Regulates CNS Myelination., PMID:30551998
The membrane palmitoylated protein, MPP6, is involved in myelin formation in the mouse peripheral nervous system., PMID:30357511
Quantitative Analysis of Interaction Between CADM1 and Its Binding Cell-Surface Proteins Using Surface Plasmon Resonance Imaging., PMID:30131958
Nectin-like molecule-4/cell adhesion molecule 4 inhibits the ligand-induced dimerization of ErbB3 with ErbB2., PMID:28900130
Necl-4 enhances the PLCγ-c-Raf-MEK-ERK pathway without affecting internalization of VEGFR2., PMID:28601637
Necl 4 and RNase 5 Are Important Biomarkers for Gastric and Colon Adenocarcinomas., PMID:28561015
Loss of CADM4 expression is associated with poor prognosis in small intestinal adenocarcinomas., PMID:28444978
SRC-2-mediated coactivation of anti-tumorigenic target genes suppresses MYC-induced liver cancer., PMID:28273073
Long Noncoding RNA LINC00673 Is Activated by SP1 and Exerts Oncogenic Properties by Interacting with LSD1 and EZH2 in Gastric Cancer., PMID:28214253
Nectin-like 4 Complexes with Choline Transporter-like Protein-1 and Regulates Schwann Cell Choline Homeostasis and Lipid Biogenesis in Vitro., PMID:28119456
Clinicopathological significance of Necl-4 expression in pancreatic ductal adenocarcinoma., PMID:27980052
Cadm3 (Necl-1) interferes with the activation of the PI3 kinase/Akt signaling cascade and inhibits Schwann cell myelination in vitro., PMID:27658374
Loss of Cdk5 function in the nucleus accumbens decreases wheel running and may mediate age-related declines in voluntary physical activity., PMID:27461471
Involvement of membrane skeletal molecules in the Schmidt-Lanterman incisure in Schwann cells., PMID:26541343
The Cell Adhesion Molecule Necl-4/CADM4 Serves as a Novel Regulator for Contact Inhibition of Cell Movement and Proliferation., PMID:25893857
Identification of protein markers in patients infected with Plasmodium knowlesi, Plasmodium falciparum and Plasmodium vivax., PMID:25372941
Cadm4 restricts the production of cardiac outflow tract progenitor cells., PMID:24813897
Genetic deletion of Cadm4 results in myelin abnormalities resembling Charcot-Marie-Tooth neuropathy., PMID:23825401
Necl-4/SynCAM-4 is expressed in myelinating oligodendrocytes but not required for axonal myelination., PMID:23700466
Interaction of Necl-4/CADM4 with ErbB3 and integrin α6 β4 and inhibition of ErbB2/ErbB3 signaling and hemidesmosome disassembly., PMID:23611113
Clinicopathological significance of CADM4 expression in invasive ductal carcinoma of the breast., PMID:23559354
Synaptic adhesion molecules in Cadm family at the neuromuscular junction., PMID:23505055
An essential role of MAG in mediating axon-myelin attachment in Charcot-Marie-Tooth 1A disease., PMID:22940629
Clinicopathological significance of CADM4 expression, and its correlation with expression of E-cadherin and Ki-67 in colorectal adenocarcinomas., PMID:22718847
Comparative proteomic analysis of primary schwann cells and a spontaneously immortalized schwann cell line RSC 96: a comprehensive overview with a focus on cell adhesion and migration related proteins., PMID:22519560
Aberrations of a cell adhesion molecule CADM4 in renal clear cell carcinoma., PMID:21544807
Localization of Cadm2a and Cadm3 proteins during development of the zebrafish nervous system., PMID:21456004
Hypoexpression and epigenetic regulation of candidate tumor suppressor gene CADM-2 in human prostate cancer., PMID:21062931
The cell adhesion nectin-like molecules (Necl) 1 and 4 suppress the growth and tumorigenic ability of colon cancer cells., PMID:19565570
Embryonic corneal Schwann cells express some Schwann cell marker mRNAs, but no mature Schwann cell marker proteins., PMID:19387082
Nectin-like proteins mediate axon Schwann cell interactions along the internode and are essential for myelination., PMID:17724124
Cell adhesion and prostate tumor-suppressor activity of TSLL2/IGSF4C, an immunoglobulin superfamily molecule homologous to TSLC1/IGSF4., PMID:16261159
Isolation of the TSLL1 and TSLL2 genes, members of the tumor suppressor TSLC1 gene family encoding transmembrane proteins., PMID:11536053
For research use only. Not for human or drug use.
