Catalog No.
YHH32501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Lys79-Ser181
Predicted molecular weight
13.84 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q16630
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Pre-mRNA cleavage factor Im 68 kDa subunit, CFIM68, Protein HPBRII-4/7, Cleavage and polyadenylation specificity factor subunit 6, CPSF6, CFIm68, CPSF 68 kDa subunit, Cleavage and polyadenylation specificity factor 68 kDa subunit, Cleavage factor Im complex 68 kDa subunit
NUDT21 lactylation reprograms alternative polyadenylation to promote cuproptosis resistance., PMID:40425546
Mycobacterium tuberculosis modulates NUDT21-mediated alternative polyadenylation to enhance FTH1 expression in macrophages and promotes intracellular growth., PMID:40384984
The Complex Interactions Between HIV-1 and Human Host Cell Genome: From Molecular Mechanisms to Clinical Practice., PMID:40244051
Structural and mechanistic bases for resistance of the M66I capsid variant to lenacapavir., PMID:40231850
CPSF6 promotes HIV-1 preintegration complex function., PMID:40202316
Spatiotemporal binding of cyclophilin A and CPSF6 to capsid regulates HIV-1 nuclear entry and integration., PMID:40013779
m6A-mediated regulation of CPSF6 by METTL3 promotes oxaliplatin resistance in colorectal cancer through enhanced glycolysis., PMID:40010558
E3 ligase SYVN1-mediated polyubiquitination of CPSF6 promotes alternative polyadenylation and antivirus effects of macrophages., PMID:39951376
Structural insights into HIV-2 CA lattice formation and FG-pocket binding revealed by single-particle cryo-EM., PMID:39864060
Cyclophilin A Regulates Tripartite Motif 5 Alpha Restriction of HIV-1., PMID:39859212
The nuclear localization signal of CPSF6 governs post-nuclear import steps of HIV-1 infection., PMID:39823525
CPSF6-RARγ interacts with histone deacetylase 3 to promote myeloid transformation in RARG-fusion acute myeloid leukemia., PMID:39805830
CircSugp1 interacts with CPSF6 to modulate intestinal mucosa repair by regulating alternative polyadenylation-mediated shortening of the Wdr89 3'UTR., PMID:39662264
Structural and Mechanistic Bases for Resistance of the M66I Capsid Variant to Lenacapavir., PMID:39651162
Identification of pathological pathways centered on circRNA dysregulation in association with irreversible progression of Alzheimer's disease., PMID:39529134
Structural insights into HIV-2 CA lattice formation and FG-pocket binding revealed by single particle cryo-EM., PMID:39416035
HIV-1 usurps mixed-charge domain-dependent CPSF6 phase separation for higher-order capsid binding, nuclear entry and viral DNA integration., PMID:39258548
Inhibiting circ_0000673 blocks the progression of colorectal cancer through downregulating CPSF6 via targeting miR-548b-3p., PMID:39225594
Retraction note to: RNA-binding protein CPSF6 regulates IBSP to affect pyroptosis in gastric cancer., PMID:38994163
Negative Regulation of CPSF6 Suppresses the Warburg Effect and Angiogenesis Leading to Tumor Progression Via c-Myc Signaling Network: Potential Therapeutic Target for Liver Cancer Therapy., PMID:38993554
Identification the role of necroptosis in rheumatoid arthritis by WGCNA network., PMID:38869013
CD34/S100 protein-positive, NTRK1-rearranged infantile fibrosarcoma-like tumors in genitourinary system: two cases expanding the clinicopathologic spectrum and illustrating the diagnostic dilemma., PMID:38801436
HIV-1 Capsid Rapidly Induces Long-Lived CPSF6 Puncta in Non-Dividing Cells, but Similar Puncta Already Exist in Uninfected T-Cells., PMID:38793552
Detection of CPSF6 in Biomolecular Condensates as a Reporter of HIV-1 Nuclear Import., PMID:38743225
Characterization of Nuclear HIV-Induced Membraneless Organelles Through Fluorescence Microscopy., PMID:38743224
Spatiotemporal binding of cyclophilin A and CPSF6 to capsid regulates HIV-1 nuclear entry and integration., PMID:38645162
Spatial resolution of HIV-1 post-entry steps in resting CD4 T cells., PMID:38478523
Downregulation of CPSF6 leads to global mRNA 3' UTR shortening and enhanced antiviral immune responses., PMID:38416782
HIV-1-induced translocation of CPSF6 to biomolecular condensates., PMID:38267295
The capsid revolution., PMID:38037430
CPSF6 regulates alternative polyadenylation and proliferation of cancer cells through phase separation., PMID:37777964
Capsid-host interactions for HIV-1 ingress., PMID:37750702
RNA-binding protein CPSF6 regulates IBSP to affect pyroptosis in gastric cancer., PMID:37746647
Multidisciplinary studies with mutated HIV-1 capsid proteins reveal structural mechanisms of lattice stabilization., PMID:37699872
Exploratory Study Analyzing the Urinary Peptidome of T2DM Patients Suggests Changes in ECM but Also Inflammatory and Metabolic Pathways Following GLP-1R Agonist Treatment., PMID:37686344
A twin UGUA motif directs the balance between gene isoforms through CFIm and the mTORC1 signaling pathway., PMID:37665675
Formation of nuclear CPSF6/CPSF5 biomolecular condensates upon HIV-1 entry into the nucleus is important for productive infection., PMID:37414787
Alternative polyadenylation factor CPSF6 regulates temperature compensation of the mammalian circadian clock., PMID:37379316
Quality assessment of traditional Chinese medicine using quality biomarkers: Compound DanShen dripping pills as an example., PMID:37226600
HIV-Induced CPSF6 Condensates., PMID:37061085
Two structural switches in HIV-1 capsid regulate capsid curvature and host factor binding., PMID:37040417
Reduction of mRNA m6A associates with glucose metabolism via YTHDC1 in human and mice., PMID:36878322
CPSF6-mediated XBP1 3'UTR shortening attenuates cisplatin-induced ER stress and elevates chemo-resistance in lung adenocarcinoma., PMID:36821972
Alternative polyadenylation alters protein dosage by switching between intronic and 3'UTR sites., PMID:36800428
A global study for acute myeloid leukemia with RARG rearrangement., PMID:36799929
Characterization of Megabat-Favored, CA-Dependent Susceptibility to Retrovirus Infection., PMID:36779757
NTRK-rearranged spindle cell neoplasms: a clinicopathological and molecular study of 13 cases with peculiar characteristics at one of the largest institutions in China., PMID:36641377
Nutritional compensation of the circadian clock is a conserved process influenced by gene expression regulation and mRNA stability., PMID:36603054
CFIm-mediated alternative polyadenylation safeguards the development of mammalian pre-implantation embryos., PMID:36563685
The roles of CPSF6 in proliferation, apoptosis and tumorigenicity of lung adenocarcinoma., PMID:36446361
For research use only. Not for human or drug use.
