Catalog No.
YHK95801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asp718-Glu874
Predicted molecular weight
19.91 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q8N573
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Oxidation resistance protein 1, OXR1
Oxr1 and Ncoa7 regulate V-ATPase to achieve optimal pH for glycosylation within the Golgi apparatus and trans-Golgi network., PMID:40445757
Forced wheel running pre-conditioning diminishes reward learning induced by methamphetamine: Involvement of orexin 1 receptor in the hippocampus., PMID:40154671
Divergent effects of noradrenergic activation and orexin receptor 1 blockade on hippocampal structure, anxiety-like behavior, and social interaction following chronic stress., PMID:40073949
Modulation of noradrenergic signalling reverses stress-induced changes in the hippocampus: Involvement of orexinergic systems., PMID:39909296
V-ATPase Disassembly at the Yeast Lysosome-Like Vacuole Is a Phenotypic Driver of Lysosome Dysfunction in Replicative Aging., PMID:39817304
Function of orexin-1 receptor signaling in the olfactory tubercle in odor-guided attraction and aversion., PMID:39725686
Spatial mRNA expression patterns of orexin receptors in the dorsal hippocampus., PMID:39433837
Integrated machine learning and bioinformatic analysis of mitochondrial-related signature in chronic rhinosinusitis with nasal polyps., PMID:39328210
Genetic variants associated with response to anti-CGRP monoclonal antibody therapy in a chronic migraine Han Chinese population., PMID:39266962
Interaction between the TBC1D24 TLDc domain and the KIBRA C2 domain is disrupted by two epilepsy-associated TBC1D24 missense variants., PMID:39214300
A susceptibility gene signature for ERBB2-driven mammary tumour development and metastasis in collaborative cross mice., PMID:39067134
Neuroinflammation and Lysosomal Abnormalities Characterise the Essential Role for Oxidation Resistance 1 in the Developing and Adult Cerebellum., PMID:38929124
Therapeutic effects of orexin-A in sepsis-associated encephalopathy in mice., PMID:38760784
Human V-ATPase function is positively and negatively regulated by TLDc proteins., PMID:38593795
Yeast TLDc domain proteins regulate assembly state and subcellular localization of the V-ATPase., PMID:38589611
Molecular mechanism of Oxr1p mediated disassembly of yeast V-ATPase., PMID:38565737
BRG1 accelerates mesothelial cell senescence and peritoneal fibrosis by inhibiting mitophagy through repression of OXR1., PMID:38311259
OXR1 maintains the retromer to delay brain aging under dietary restriction., PMID:38212606
TLDc Domain-Containing Genes in Autism Spectrum Disorder: New Players in the Oxidative Stress Response., PMID:37958785
Omaveloxolone ameliorates cognitive dysfunction in APP/PS1 mice by stabilizing the STAT3 pathway., PMID:37951537
Iridium metal complex targeting oxidation resistance 1 protein attenuates spinal cord injury by inhibiting oxidative stress-associated reactive oxygen species., PMID:37857001
A loss-of-function mutation in human Oxidation Resistance 1 disrupts the spatial-temporal regulation of histone arginine methylation in neurodevelopment., PMID:37773136
Lateral hypothalamic orexin neurons mediate electroacupuncture-induced anxiolytic effects in a rat model of post-traumatic stress disorder., PMID:37481143
A Review of the Physiological Role of Hypocretin in the Ventral Tegmental Area in Reward and Drug Dependence., PMID:37409547
Genomic adaptation to extreme climate conditions in beef cattle as a consequence of cross-breeding program., PMID:37024818
Exogenous L-lactate administration in rat hippocampus increases expression of key regulators of mitochondrial biogenesis and antioxidant defense., PMID:37008779
Orexin-A exerts neuroprotective effect in experimental intracerebral hemorrhage by suppressing autophagy via OXR1-mediated ERK/mTOR signaling pathway., PMID:36619670
Non-prophylactic resveratrol-mediated protection of neurite integrity under chronic hypoxia is associated with reduction of Cav1.2 channel expression and calcium overloading., PMID:36587745
Blockade of orexin receptor type-1 by SB-334867 and activation of orexin receptor type-2 attenuate morphine tolerance in rats., PMID:36480169
MicroRNA-668-3p regulates oxidative stress and cell damage induced by Aβ1-42 by targeting the OXR1/p53-p21 axis., PMID:36172098
A novel recessive mutation in OXR1 is identified in patient with hearing loss recapitulated by the knockdown zebrafish., PMID:36130215
Low-intensity focused ultrasound attenuates early traumatic brain injury by OX-A/NF-κB/NLRP3 signaling pathway., PMID:36126193
Bromocriptine-QR Therapy Reduces Sympathetic Tone and Ameliorates a Pro-Oxidative/Pro-Inflammatory Phenotype in Peripheral Blood Mononuclear Cells and Plasma of Type 2 Diabetes Subjects., PMID:36012132
Gene therapy targeting inflammatory pericytes corrects angiopathy during diabetic wound healing., PMID:35990676
Hypocretin/orexin system in the nucleus accumbens as a promising player in the extinction and reinstatement of methamphetamine-induced CPP., PMID:35988849
OXR1 signaling pathway as a possible mechanism of elastase-induced oxidative damage in pulmonary cells: the protective role of ellagic acid., PMID:35841468
A Locus on Chromosome 15 Contributes to Acute Ozone-induced Lung Injury in Collaborative Cross Mice., PMID:35816602
Neurobiology of the Orexin System and Its Potential Role in the Regulation of Hedonic Tone., PMID:35203914
6-Shogaol Inhibits Oxidative Stress-Induced Rat Vascular Smooth Muscle Cell Apoptosis by Regulating OXR1-p53 Axis., PMID:35174215
Tracing the Origin of the RSPO2 Long-Hair Allele and Epistatic Interaction between FGF5 and RSPO2 in Sapsaree Dog., PMID:35052442
Oxidative stress protein Oxr1 promotes V-ATPase holoenzyme disassembly in catalytic activity-independent manner., PMID:34918374
The evolutionary conserved TLDc domain defines a new class of (H+)V-ATPase interacting proteins., PMID:34811399
Optogenetic stimulation of lateral hypothalamic orexin/dynorphin inputs in the ventral tegmental area potentiates mesolimbic dopamine neurotransmission and promotes reward-seeking behaviours., PMID:34663867
Oxidative Stress Genes in Diabetes Mellitus Type 2: Association with Diabetic Kidney Disease., PMID:34545296
The OxrA Protein of Aspergillus fumigatus Is Required for the Oxidative Stress Response and Fungal Pathogenesis., PMID:34524893
Oxidative Stress Resistance 1 Gene Therapy Retards Neurodegeneration in the rd1 Mutant Mouse Model of Retinopathy., PMID:34505865
Human adipose tissue is a putative direct target of daytime orexin with favorable metabolic effects: A cross-sectional study., PMID:34472713
Prognostic significance of OXR1 in urothelial carcinoma: low OXR1 expression is associated with worse survival., PMID:34467778
MicroRNA-29a Mitigates Osteoblast Senescence and Counteracts Bone Loss through Oxidation Resistance-1 Control of FoxO3 Methylation., PMID:34439496
Aerobic training associated with an active lifestyle exerts a protective effect against oxidative damage in hypothalamus and liver: The involvement of energy metabolism., PMID:34303768
For research use only. Not for human or drug use.
