Catalog No.
YHA30801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asp2-Gly92
Predicted molecular weight
22.86 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O14796
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
EAT2, SH2D1B, SH2 domain-containing protein 1B, EAT-2, EWS/FLI1-activated transcript 2
DNA Methylation of KLRC1 and KLRC3 in Autoimmune Thyroiditis: Perspective of Different Water Iodine Exposure., PMID:39401997
Single-cell profiling identifies a CD8bright CD244bright Natural Killer cell subset that reflects disease activity in HLA-A29-positive birdshot chorioretinopathy., PMID:39085199
Detailed phenotypic and functional characterization of CMV-associated adaptive NK cells in rhesus macaques., PMID:36518759
Single-cell transcriptome profiling reveals the key role of ZNF683 in natural killer cell exhaustion in multiple myeloma., PMID:36245253
Identification of immune hub genes participating in the pathogenesis and progression of Vogt-Koyanagi-Harada disease., PMID:35958546
Macrophage-mediated anti-tumor immunity against high-risk neuroblastoma., PMID:35525858
STAT4 and COL1A2 are potential diagnostic biomarkers and therapeutic targets for heart failure comorbided with depression., PMID:35367598
Chronic Active Antibody-Mediated Rejection Is Associated With the Upregulation of Interstitial But Not Glomerular Transcripts., PMID:34616398
Identification of Biomarkers for Predicting Allograft Rejection following Kidney Transplantation Based on the Weighted Gene Coexpression Network Analysis., PMID:34368360
Female-Specific Susceptibility Locus in BOC and SEC16B are Associated with Adolescent Idiopathic Scoliosis., PMID:33958541
Biotoxic effects and gene expression regulation of urban PM2.5 in southwestern China., PMID:33207436
Regulation of MHC class I-independent NK cell education by SLAM family receptors., PMID:32081197
Identification of Susceptibility Genes to Allergic Rhinitis by Gene Expression Data Sets., PMID:31794148
NK cell recognition of hematopoietic cells by SLAM-SAP families., PMID:30911116
Mechanisms of NK Cell Activation and Clinical Activity of the Therapeutic SLAMF7 Antibody, Elotuzumab in Multiple Myeloma., PMID:30455698
Plasma Exosomes From HLA-Sensitized Kidney Transplant Recipients Contain mRNA Transcripts Which Predict Development of Antibody-Mediated Rejection., PMID:28557957
Adaptive NK cells can persist in patients with GATA2 mutation depleted of stem and progenitor cells., PMID:28209719
The X-ray Crystallographic Structure of Human EAT2 (SH2D1B)., PMID:27586300
CRACC-targeting Fc-fusion protein induces activation of NK cells and DCs and improves T cell immune responses to antigenic targets., PMID:27151882
Long noncoding RNA derived from CD244 signaling epigenetically controls CD8+ T-cell immune responses in tuberculosis infection., PMID:26150504
Cytomegalovirus infection drives adaptive epigenetic diversification of NK cells with altered signaling and effector function., PMID:25786176
Use of Quantitative Real Time Polymerase Chain Reaction to Assess Gene Transcripts Associated With Antibody-Mediated Rejection of Kidney Transplants., PMID:25675206
EAT-2, a SAP-like adaptor, controls NK cell activation through phospholipase Cγ, Ca++, and Erk, leading to granule polarization., PMID:24687958
Fine specificity and molecular competition in SLAM family receptor signalling., PMID:24642916
Manipulation of EAT-2 expression promotes induction of multiple beneficial regulatory and effector functions of the human innate immune system as a novel immunomodulatory strategy., PMID:24374770
Elotuzumab directly enhances NK cell cytotoxicity against myeloma via CS1 ligation: evidence for augmented NK cell function complementing ADCC., PMID:24162108
Vaccines expressing the innate immune modulator EAT-2 elicit potent effector memory T lymphocyte responses despite pre-existing vaccine immunity., PMID:22745373
Importance and mechanism of 'switch' function of SAP family adapters., PMID:19909367
Natural killer cell dysfunction during acute infection with foot-and-mouth disease virus., PMID:19828769
Direct and indirect interactions of the cytoplasmic region of CD244 (2B4) in mice and humans with FYN kinase., PMID:17599905
Molecular analysis of NTB-A signaling: a role for EAT-2 in NTB-A-mediated activation of human NK cells., PMID:16920955
Identification and characterization of two related murine genes, Eat2a and Eat2b, encoding single SH2-domain adapters., PMID:16425036
[EAT-2: a novel regulator of natural killer cell functions]., PMID:16386214
The cytotoxicity receptor CRACC (CS-1) recruits EAT-2 and activates the PI3K and phospholipase Cgamma signaling pathways in human NK cells., PMID:16339536
Differential expression of SAP and EAT-2-binding leukocyte cell-surface molecules CD84, CD150 (SLAM), CD229 (Ly9) and CD244 (2B4)., PMID:15245368
The SAP and SLAM families in immune responses and X-linked lymphoproliferative disease., PMID:14523387
Functional requirements for interactions between CD84 and Src homology 2 domain-containing proteins and their contribution to human T cell activation., PMID:12928397
The SLAM family of immune-cell receptors., PMID:12787752
CD84 is up-regulated on a major population of human memory B cells and recruits the SH2 domain containing proteins SAP and EAT-2., PMID:12115647
Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells., PMID:11689425
X-linked lymphoproliferative disease: a progressive immunodeficiency., PMID:11244050
Crystal structures of the XLP protein SAP reveal a class of SH2 domains with extended, phosphotyrosine-independent sequence recognition., PMID:10549287
Divergent Ewing's sarcoma EWS/ETS fusions confer a common tumorigenic phenotype on NIH3T3 cells., PMID:10523827
EAT-2 is a novel SH2 domain containing protein that is up regulated by Ewing's sarcoma EWS/FLI1 fusion gene., PMID:9000139
EWS/FLI-1 fusion transcript detection and MIC2 immunohistochemical staining in the diagnosis of Ewing's sarcoma., PMID:9025840
For research use only. Not for human or drug use.
